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ConPlot: web-based application for the visualization of protein contact maps integrated with other data

SUMMARY: Covariance-based predictions of residue contacts and inter-residue distances are an increasingly popular data type in protein bioinformatics. Here we present ConPlot, a web-based application for convenient display and analysis of contact maps and distograms. Integration of predicted contact...

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Autores principales: Sánchez Rodríguez, Filomeno, Mesdaghi, Shahram, Simpkin, Adam J., Burgos-Mármol, J. Javier, Murphy, David L., Uski, Ville, Keegan, Ronan M., Rigden, Daniel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8428603/
https://www.ncbi.nlm.nih.gov/pubmed/34499718
http://dx.doi.org/10.1093/bioinformatics/btab049
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author Sánchez Rodríguez, Filomeno
Mesdaghi, Shahram
Simpkin, Adam J.
Burgos-Mármol, J. Javier
Murphy, David L.
Uski, Ville
Keegan, Ronan M.
Rigden, Daniel J.
author_facet Sánchez Rodríguez, Filomeno
Mesdaghi, Shahram
Simpkin, Adam J.
Burgos-Mármol, J. Javier
Murphy, David L.
Uski, Ville
Keegan, Ronan M.
Rigden, Daniel J.
author_sort Sánchez Rodríguez, Filomeno
collection PubMed
description SUMMARY: Covariance-based predictions of residue contacts and inter-residue distances are an increasingly popular data type in protein bioinformatics. Here we present ConPlot, a web-based application for convenient display and analysis of contact maps and distograms. Integration of predicted contact data with other predictions is often required to facilitate inference of structural features. ConPlot can therefore use the empty space near the contact map diagonal to display multiple coloured tracks representing other sequence-based predictions. Popular file formats are natively read and bespoke data can also be flexibly displayed. This novel visualization will enable easier interpretation of predicted contact maps. AVAILABILITY AND IMPLEMENTATION: available online at www.conplot.org, along with documentation and examples. Alternatively, ConPlot can be installed and used locally using the docker image from the project’s Docker Hub repository. ConPlot is licensed under the BSD 3-Clause. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
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spelling pubmed-84286032021-09-10 ConPlot: web-based application for the visualization of protein contact maps integrated with other data Sánchez Rodríguez, Filomeno Mesdaghi, Shahram Simpkin, Adam J. Burgos-Mármol, J. Javier Murphy, David L. Uski, Ville Keegan, Ronan M. Rigden, Daniel J. Bioinformatics Applications Notes SUMMARY: Covariance-based predictions of residue contacts and inter-residue distances are an increasingly popular data type in protein bioinformatics. Here we present ConPlot, a web-based application for convenient display and analysis of contact maps and distograms. Integration of predicted contact data with other predictions is often required to facilitate inference of structural features. ConPlot can therefore use the empty space near the contact map diagonal to display multiple coloured tracks representing other sequence-based predictions. Popular file formats are natively read and bespoke data can also be flexibly displayed. This novel visualization will enable easier interpretation of predicted contact maps. AVAILABILITY AND IMPLEMENTATION: available online at www.conplot.org, along with documentation and examples. Alternatively, ConPlot can be installed and used locally using the docker image from the project’s Docker Hub repository. ConPlot is licensed under the BSD 3-Clause. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online. Oxford University Press 2021-01-28 /pmc/articles/PMC8428603/ /pubmed/34499718 http://dx.doi.org/10.1093/bioinformatics/btab049 Text en © The Author(s) 2021. Published by Oxford University Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Applications Notes
Sánchez Rodríguez, Filomeno
Mesdaghi, Shahram
Simpkin, Adam J.
Burgos-Mármol, J. Javier
Murphy, David L.
Uski, Ville
Keegan, Ronan M.
Rigden, Daniel J.
ConPlot: web-based application for the visualization of protein contact maps integrated with other data
title ConPlot: web-based application for the visualization of protein contact maps integrated with other data
title_full ConPlot: web-based application for the visualization of protein contact maps integrated with other data
title_fullStr ConPlot: web-based application for the visualization of protein contact maps integrated with other data
title_full_unstemmed ConPlot: web-based application for the visualization of protein contact maps integrated with other data
title_short ConPlot: web-based application for the visualization of protein contact maps integrated with other data
title_sort conplot: web-based application for the visualization of protein contact maps integrated with other data
topic Applications Notes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8428603/
https://www.ncbi.nlm.nih.gov/pubmed/34499718
http://dx.doi.org/10.1093/bioinformatics/btab049
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