Structural characterization of the Plasmodium falciparum lactate transporter PfFNT alone and in complex with antimalarial compound MMV007839 reveals its inhibition mechanism

Plasmodium falciparum, the deadliest causal agent of malaria, caused more than half of the 229 million malaria cases worldwide in 2019. The emergence and spreading of frontline drug-resistant Plasmodium strains are challenging to overcome in the battle against malaria and raise urgent demands for no...

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Detalles Bibliográficos
Autores principales: Peng, Xi, Wang, Nan, Zhu, Angqi, Xu, Hanwen, Li, Jialu, Zhou, Yanxia, Wang, Chen, Xiao, Qingjie, Guo, Li, Liu, Fei, Jia, Zhi-jun, Duan, Huaichuan, Hu, Jianping, Yuan, Weidan, Geng, Jia, Yan, Chuangye, Jiang, Xin, Deng, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8428694/
https://www.ncbi.nlm.nih.gov/pubmed/34499638
http://dx.doi.org/10.1371/journal.pbio.3001386

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