The Assessment of the Platelet Function During the Acute Phase of ST-segment Elevation Myocardial Infarction in Essential Thrombocythemia

We encountered a case of ST-segment elevation myocardial infarction (STEMI) as the first clinical manifestation of essential thrombocythemia (ET). Platelet function tests revealed high thrombogenicity during primary percutaneous coronary intervention compared with general cardiovascular patients, wh...

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Autores principales: Kikuchi, Shinnosuke, Hibi, Kiyoshi, Tamura, Kouichi, Kimura, Kazuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8429280/
https://www.ncbi.nlm.nih.gov/pubmed/33716280
http://dx.doi.org/10.2169/internalmedicine.6095-20
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author Kikuchi, Shinnosuke
Hibi, Kiyoshi
Tamura, Kouichi
Kimura, Kazuo
author_facet Kikuchi, Shinnosuke
Hibi, Kiyoshi
Tamura, Kouichi
Kimura, Kazuo
author_sort Kikuchi, Shinnosuke
collection PubMed
description We encountered a case of ST-segment elevation myocardial infarction (STEMI) as the first clinical manifestation of essential thrombocythemia (ET). Platelet function tests revealed high thrombogenicity during primary percutaneous coronary intervention compared with general cardiovascular patients, whereas the platelet function two weeks after admission was effectively suppressed by dual antiplatelet therapy. The patient, who lacked cytoreduction, suffered from recurrent STEMI because of poor compliance with antiplatelet drugs. The risk of acute coronary occlusion may be high during the acute phase of STEMI in ET patients because of high thrombogenicity. Insufficient antiplatelet therapy and no cytoreduction are also risk factors for recurrent coronary events.
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spelling pubmed-84292802021-09-24 The Assessment of the Platelet Function During the Acute Phase of ST-segment Elevation Myocardial Infarction in Essential Thrombocythemia Kikuchi, Shinnosuke Hibi, Kiyoshi Tamura, Kouichi Kimura, Kazuo Intern Med Case Report We encountered a case of ST-segment elevation myocardial infarction (STEMI) as the first clinical manifestation of essential thrombocythemia (ET). Platelet function tests revealed high thrombogenicity during primary percutaneous coronary intervention compared with general cardiovascular patients, whereas the platelet function two weeks after admission was effectively suppressed by dual antiplatelet therapy. The patient, who lacked cytoreduction, suffered from recurrent STEMI because of poor compliance with antiplatelet drugs. The risk of acute coronary occlusion may be high during the acute phase of STEMI in ET patients because of high thrombogenicity. Insufficient antiplatelet therapy and no cytoreduction are also risk factors for recurrent coronary events. The Japanese Society of Internal Medicine 2021-03-15 2021-08-15 /pmc/articles/PMC8429280/ /pubmed/33716280 http://dx.doi.org/10.2169/internalmedicine.6095-20 Text en Copyright © 2021 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Kikuchi, Shinnosuke
Hibi, Kiyoshi
Tamura, Kouichi
Kimura, Kazuo
The Assessment of the Platelet Function During the Acute Phase of ST-segment Elevation Myocardial Infarction in Essential Thrombocythemia
title The Assessment of the Platelet Function During the Acute Phase of ST-segment Elevation Myocardial Infarction in Essential Thrombocythemia
title_full The Assessment of the Platelet Function During the Acute Phase of ST-segment Elevation Myocardial Infarction in Essential Thrombocythemia
title_fullStr The Assessment of the Platelet Function During the Acute Phase of ST-segment Elevation Myocardial Infarction in Essential Thrombocythemia
title_full_unstemmed The Assessment of the Platelet Function During the Acute Phase of ST-segment Elevation Myocardial Infarction in Essential Thrombocythemia
title_short The Assessment of the Platelet Function During the Acute Phase of ST-segment Elevation Myocardial Infarction in Essential Thrombocythemia
title_sort assessment of the platelet function during the acute phase of st-segment elevation myocardial infarction in essential thrombocythemia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8429280/
https://www.ncbi.nlm.nih.gov/pubmed/33716280
http://dx.doi.org/10.2169/internalmedicine.6095-20
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