Ramucirumab-related Oral Pyogenic Granuloma: A Report of Two Cases

Pyogenic granuloma (PG) is a granulomatous elevated lesion that occurs on the skin and mucous membranes. We herein report two cases of intra-oral PG that developed during the administration of ramucirumab for gastric cancer. Case 1 involved a 55-year-old man with a 6-mm tumor on the right tongue, an...

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Detalles Bibliográficos
Autores principales: Aragaki, Tadanobu, Tomomatsu, Nobuyoshi, Michi, Yasuyuki, Hosaka, Hisashi, Fukai, Yasuyuki, Iijima, Misa, Yoda, Tetsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8429295/
https://www.ncbi.nlm.nih.gov/pubmed/33678742
http://dx.doi.org/10.2169/internalmedicine.6650-20
Descripción
Sumario:Pyogenic granuloma (PG) is a granulomatous elevated lesion that occurs on the skin and mucous membranes. We herein report two cases of intra-oral PG that developed during the administration of ramucirumab for gastric cancer. Case 1 involved a 55-year-old man with a 6-mm tumor on the right tongue, and case 2 involved a 67-year-old man with a 5-mm tumor on the upper lip. The imbalance in angiogenesis caused by ramucirumab and the deterioration in the local oral environment were suggested to have caused the PG. Medical and dental collaboration is essential during the administration of ramucirumab.

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