Acquired Coagulation Factor V Inhibitor That Was Successfully Treated with Oral Corticosteroid Therapy

Acquired coagulation factor V (FV) inhibitors are rare disorders in which antibodies against FV develop under various conditions. We herein report the case of a 71-year-old woman with FV inhibitor during radiochemotherapy for pancreatic cancer. Multiple purpuras suddenly appeared on her bilateral up...

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Detalles Bibliográficos
Autores principales: Yokota, Yoshihiro, Inatomi, Osamu, Nakagawa, Minami, Kakuda, Kazuki, Hiroe, Kousuke, Sakai, Shigeki, Osaki, Rie, Iwasa, Masaki, Kawahara, Masahiro, Kito, Katsuyuki, Andoh, Akira, Bamba, Hiromichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8429299/
https://www.ncbi.nlm.nih.gov/pubmed/34121013
http://dx.doi.org/10.2169/internalmedicine.7453-21
Descripción
Sumario:Acquired coagulation factor V (FV) inhibitors are rare disorders in which antibodies against FV develop under various conditions. We herein report the case of a 71-year-old woman with FV inhibitor during radiochemotherapy for pancreatic cancer. Multiple purpuras suddenly appeared on her bilateral upper limbs with prolonged coagulation data (APTT 97.3 seconds). The FV activity was less than 3% and the FV inhibitor was positive (1.7 B.U./mL). Oral prednisolone induced a rapid normalization of the coagulation data and FV activity and a rapid disappearance of FV inhibitor within 7 days. Early diagnosis and treatment may therefore be important in cases of FV inhibitor.

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