Inhibition of CCL2 by bindarit alleviates diabetes-associated periodontitis by suppressing inflammatory monocyte infiltration and altering macrophage properties

Diabetes-associated periodontitis (DP) aggravates diabetic complications and increases mortality from diabetes. DP is caused by diabetes-enhanced host immune-inflammatory responses to bacterial insult. In this study, we found that persistently elevated CCL2 levels in combination with proinflammatory...

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Autores principales: Shen, Zongshan, Kuang, Shuhong, Zhang, Min, Huang, Xin, Chen, Jiayao, Guan, Meiliang, Qin, Wei, Xu, Hockin H. K., Lin, Zhengmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8429574/
https://www.ncbi.nlm.nih.gov/pubmed/32678310
http://dx.doi.org/10.1038/s41423-020-0500-1
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author Shen, Zongshan
Kuang, Shuhong
Zhang, Min
Huang, Xin
Chen, Jiayao
Guan, Meiliang
Qin, Wei
Xu, Hockin H. K.
Lin, Zhengmei
author_facet Shen, Zongshan
Kuang, Shuhong
Zhang, Min
Huang, Xin
Chen, Jiayao
Guan, Meiliang
Qin, Wei
Xu, Hockin H. K.
Lin, Zhengmei
author_sort Shen, Zongshan
collection PubMed
description Diabetes-associated periodontitis (DP) aggravates diabetic complications and increases mortality from diabetes. DP is caused by diabetes-enhanced host immune-inflammatory responses to bacterial insult. In this study, we found that persistently elevated CCL2 levels in combination with proinflammatory monocyte infiltration of periodontal tissues were closely related to DP. Moreover, inhibition of CCL2 by oral administration of bindarit reduced alveolar bone loss and increased periodontal epithelial thickness by suppressing periodontal inflammation. Furthermore, bindarit suppressed the infiltration of proinflammatory monocytes and altered the inflammatory properties of macrophages in the diabetic periodontium. This finding provides a basis for the development of an effective therapeutic approach for treating DP.
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spelling pubmed-84295742021-09-24 Inhibition of CCL2 by bindarit alleviates diabetes-associated periodontitis by suppressing inflammatory monocyte infiltration and altering macrophage properties Shen, Zongshan Kuang, Shuhong Zhang, Min Huang, Xin Chen, Jiayao Guan, Meiliang Qin, Wei Xu, Hockin H. K. Lin, Zhengmei Cell Mol Immunol Article Diabetes-associated periodontitis (DP) aggravates diabetic complications and increases mortality from diabetes. DP is caused by diabetes-enhanced host immune-inflammatory responses to bacterial insult. In this study, we found that persistently elevated CCL2 levels in combination with proinflammatory monocyte infiltration of periodontal tissues were closely related to DP. Moreover, inhibition of CCL2 by oral administration of bindarit reduced alveolar bone loss and increased periodontal epithelial thickness by suppressing periodontal inflammation. Furthermore, bindarit suppressed the infiltration of proinflammatory monocytes and altered the inflammatory properties of macrophages in the diabetic periodontium. This finding provides a basis for the development of an effective therapeutic approach for treating DP. Nature Publishing Group UK 2020-07-16 2021-09 /pmc/articles/PMC8429574/ /pubmed/32678310 http://dx.doi.org/10.1038/s41423-020-0500-1 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Shen, Zongshan
Kuang, Shuhong
Zhang, Min
Huang, Xin
Chen, Jiayao
Guan, Meiliang
Qin, Wei
Xu, Hockin H. K.
Lin, Zhengmei
Inhibition of CCL2 by bindarit alleviates diabetes-associated periodontitis by suppressing inflammatory monocyte infiltration and altering macrophage properties
title Inhibition of CCL2 by bindarit alleviates diabetes-associated periodontitis by suppressing inflammatory monocyte infiltration and altering macrophage properties
title_full Inhibition of CCL2 by bindarit alleviates diabetes-associated periodontitis by suppressing inflammatory monocyte infiltration and altering macrophage properties
title_fullStr Inhibition of CCL2 by bindarit alleviates diabetes-associated periodontitis by suppressing inflammatory monocyte infiltration and altering macrophage properties
title_full_unstemmed Inhibition of CCL2 by bindarit alleviates diabetes-associated periodontitis by suppressing inflammatory monocyte infiltration and altering macrophage properties
title_short Inhibition of CCL2 by bindarit alleviates diabetes-associated periodontitis by suppressing inflammatory monocyte infiltration and altering macrophage properties
title_sort inhibition of ccl2 by bindarit alleviates diabetes-associated periodontitis by suppressing inflammatory monocyte infiltration and altering macrophage properties
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8429574/
https://www.ncbi.nlm.nih.gov/pubmed/32678310
http://dx.doi.org/10.1038/s41423-020-0500-1
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