Phase I study of CAR-T cells with PD-1 and TCR disruption in mesothelin-positive solid tumors

Programmed cell death protein-1 (PD-1)-mediated immunosuppression has been proposed to contribute to the limited clinical efficacy of chimeric antigen receptor T (CAR-T) cells in solid tumors. We generated PD-1 and T cell receptor (TCR) deficient mesothelin-specific CAR-T (MPTK-CAR-T) cells using CR...

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Detalles Bibliográficos
Autores principales: Wang, Zhenguang, Li, Na, Feng, Kaichao, Chen, Meixia, Zhang, Yan, Liu, Yang, Yang, Qingming, Nie, Jing, Tang, Na, Zhang, Xingying, Cheng, Chen, Shen, Lianjun, He, Jiaping, Ye, Xun, Cao, Wei, Wang, Haoyi, Han, Weidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8429583/
https://www.ncbi.nlm.nih.gov/pubmed/34381179
http://dx.doi.org/10.1038/s41423-021-00749-x

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