Pathophysiology of COVID-19: Everywhere You Look You Will See ACE(2)!

Angiotensin converting enzyme 2 (ACE(2)) seems to be a central actor in the pathophysiology of SARS-Cov-2 infection. First, it acts as the receptor for the virus and permits its attachment to cells expressing ACE(2). Second, the relative deficiency of ACE(2) during infection could be linked to sever...

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Detalles Bibliográficos
Autores principales: Cousin, Vladimir L., Giraud, Raphael, Bendjelid, Karim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8429613/
https://www.ncbi.nlm.nih.gov/pubmed/34513868
http://dx.doi.org/10.3389/fmed.2021.694029
Descripción
Sumario:Angiotensin converting enzyme 2 (ACE(2)) seems to be a central actor in the pathophysiology of SARS-Cov-2 infection. First, it acts as the receptor for the virus and permits its attachment to cells expressing ACE(2). Second, the relative deficiency of ACE(2) during infection could be linked to several clinical features encountered during the disease, like ARDS and coagulation abnormalities. This study explores the strong link between ACE(2) and the majority of risk factors for the severe evolution of COVID-19. It seems that all these risks factors are linked to an increased level of ACE(2) and/or imbalance in ACE/ACE(2).

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