Pathophysiology of COVID-19: Everywhere You Look You Will See ACE(2)!

Angiotensin converting enzyme 2 (ACE(2)) seems to be a central actor in the pathophysiology of SARS-Cov-2 infection. First, it acts as the receptor for the virus and permits its attachment to cells expressing ACE(2). Second, the relative deficiency of ACE(2) during infection could be linked to sever...

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Autores principales: Cousin, Vladimir L., Giraud, Raphael, Bendjelid, Karim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8429613/
https://www.ncbi.nlm.nih.gov/pubmed/34513868
http://dx.doi.org/10.3389/fmed.2021.694029
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author Cousin, Vladimir L.
Giraud, Raphael
Bendjelid, Karim
author_facet Cousin, Vladimir L.
Giraud, Raphael
Bendjelid, Karim
author_sort Cousin, Vladimir L.
collection PubMed
description Angiotensin converting enzyme 2 (ACE(2)) seems to be a central actor in the pathophysiology of SARS-Cov-2 infection. First, it acts as the receptor for the virus and permits its attachment to cells expressing ACE(2). Second, the relative deficiency of ACE(2) during infection could be linked to several clinical features encountered during the disease, like ARDS and coagulation abnormalities. This study explores the strong link between ACE(2) and the majority of risk factors for the severe evolution of COVID-19. It seems that all these risks factors are linked to an increased level of ACE(2) and/or imbalance in ACE/ACE(2).
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spelling pubmed-84296132021-09-11 Pathophysiology of COVID-19: Everywhere You Look You Will See ACE(2)! Cousin, Vladimir L. Giraud, Raphael Bendjelid, Karim Front Med (Lausanne) Medicine Angiotensin converting enzyme 2 (ACE(2)) seems to be a central actor in the pathophysiology of SARS-Cov-2 infection. First, it acts as the receptor for the virus and permits its attachment to cells expressing ACE(2). Second, the relative deficiency of ACE(2) during infection could be linked to several clinical features encountered during the disease, like ARDS and coagulation abnormalities. This study explores the strong link between ACE(2) and the majority of risk factors for the severe evolution of COVID-19. It seems that all these risks factors are linked to an increased level of ACE(2) and/or imbalance in ACE/ACE(2). Frontiers Media S.A. 2021-08-27 /pmc/articles/PMC8429613/ /pubmed/34513868 http://dx.doi.org/10.3389/fmed.2021.694029 Text en Copyright © 2021 Cousin, Giraud and Bendjelid. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Cousin, Vladimir L.
Giraud, Raphael
Bendjelid, Karim
Pathophysiology of COVID-19: Everywhere You Look You Will See ACE(2)!
title Pathophysiology of COVID-19: Everywhere You Look You Will See ACE(2)!
title_full Pathophysiology of COVID-19: Everywhere You Look You Will See ACE(2)!
title_fullStr Pathophysiology of COVID-19: Everywhere You Look You Will See ACE(2)!
title_full_unstemmed Pathophysiology of COVID-19: Everywhere You Look You Will See ACE(2)!
title_short Pathophysiology of COVID-19: Everywhere You Look You Will See ACE(2)!
title_sort pathophysiology of covid-19: everywhere you look you will see ace(2)!
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8429613/
https://www.ncbi.nlm.nih.gov/pubmed/34513868
http://dx.doi.org/10.3389/fmed.2021.694029
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