Cargando…

Schizophrenia, autism spectrum disorders and developmental disorders share specific disruptive coding mutations

People with schizophrenia are enriched for rare coding variants in genes associated with neurodevelopmental disorders, particularly autism spectrum disorders and intellectual disability. However, it is unclear if the same changes to gene function that increase risk to neurodevelopmental disorders al...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rees, Elliott, Creeth, Hugo D. J., Hwu, Hai-Gwo, Chen, Wei J., Tsuang, Ming, Glatt, Stephen J., Rey, Romain, Kirov, George, Walters, James T. R., Holmans, Peter, Owen, Michael J., O’Donovan, Michael C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8429694/ https://www.ncbi.nlm.nih.gov/pubmed/34504065 http://dx.doi.org/10.1038/s41467-021-25532-4

Ejemplares similares

Ultrarare Coding Variants and Cognitive Function in Schizophrenia
por: Creeth, Hugo D. J., et al.
Publicado: (2022)

Family-based analysis of the contribution of rare and common genetic variants to school performance in schizophrenia
por: Rammos, Alexandros, et al.
Publicado: (2023)

Genetic association of FMRP targets with psychiatric disorders
por: Clifton, Nicholas E., et al.
Publicado: (2020)

Gender differences in CNV burden do not confound schizophrenia CNV associations
por: Han, Jun, et al.
Publicado: (2016)

De novo CNVs in bipolar affective disorder and schizophrenia
por: Georgieva, Lyudmila, et al.
Publicado: (2014)

Biological Overlap of Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder: Evidence From Copy Number Variants
por: Martin, Joanna, et al.
Publicado: (2014)

Shared polygenic contribution between childhood attention-deficit hyperactivity disorder and adult schizophrenia†
por: Hamshere, Marian L., et al.
Publicado: (2013)

A brief report: de novo copy number variants in children with attention deficit hyperactivity disorder
por: Martin, Joanna, et al.
Publicado: (2020)

Association of Genetic Liability to Psychotic Experiences With Neuropsychotic Disorders and Traits
por: Legge, Sophie E., et al.
Publicado: (2019)

S178. SHOULD SCHIZOAFFECTIVE DISORDER DEPRESSED-TYPE BE DISTINCT FROM SCHIZOPHRENIA? ANALYSIS OF GENETIC LIABILITY AND LIFETIME CLINICAL CHARACTERISTICS
por: Dennison, Charlotte, et al.
Publicado: (2020)

Novel Insight Into the Etiology of Autism Spectrum Disorder Gained by Integrating Expression Data With Genome-wide Association Statistics
por: Pain, Oliver, et al.
Publicado: (2019)

Genetic Liabilities Differentiating Bipolar Disorder, Schizophrenia, and Major Depressive Disorder, and Phenotypic Heterogeneity in Bipolar Disorder
por: Richards, Alexander L., et al.
Publicado: (2022)

No Evidence for Enrichment in Schizophrenia for Common Allelic Associations at Imprinted Loci
por: Escott-Price, Valentina, et al.
Publicado: (2015)

Novel Findings from CNVs Implicate Inhibitory and Excitatory Signaling Complexes in Schizophrenia
por: Pocklington, Andrew J., et al.
Publicado: (2015)

Machine learning for prediction of schizophrenia using genetic and demographic factors in the UK biobank
por: Bracher-Smith, Matthew, et al.
Publicado: (2022)

Risk Factors, Clinical Features, and Polygenic Risk Scores in Schizophrenia and Schizoaffective Disorder Depressive-Type
por: Dennison, Charlotte A, et al.
Publicado: (2021)

A genome-wide study shows a limited contribution of rare copy number variants to Alzheimer's disease risk
por: Chapman, Jade, et al.
Publicado: (2013)

Dynamic expression of genes associated with schizophrenia and bipolar disorder across development
por: Clifton, Nicholas E., et al.
Publicado: (2019)

Common alleles contribute to schizophrenia in CNV carriers
por: Tansey, K E, et al.
Publicado: (2016)

Erratum: Common alleles contribute to schizophrenia in CNV carriers
por: Tansey, K E, et al.
Publicado: (2015)

Genetic disruption of voltage-gated calcium channels in psychiatric and neurological disorders
por: Heyes, Samuel, et al.
Publicado: (2015)

Autism and Sensory Processing Disorders: Shared White Matter Disruption in Sensory Pathways but Divergent Connectivity in Social-Emotional Pathways
por: Chang, Yi-Shin, et al.
Publicado: (2014)

Copy number variation in bipolar disorder
por: Green, E K, et al.
Publicado: (2016)

Cognitive performance and functional outcomes of carriers of pathogenic copy number variants: analysis of the UK Biobank
por: Kendall, Kimberley M., et al.
Publicado: (2019)

Effects of pathogenic CNVs on physical traits in participants of the UK Biobank
por: Owen, David, et al.
Publicado: (2018)

The genetics of neuropsychiatric disorders
por: Bray, Nicholas J., et al.
Publicado: (2018)

Clinical and cognitive characteristics of children with attention-deficit hyperactivity disorder, with and without copy number variants
por: Langley, Kate, et al.
Publicado: (2011)

Adaptive combination of Bayes factors as a powerful method for the joint analysis of rare and common variants
por: Lin, Wan-Yu, et al.
Publicado: (2017)

Recessive gene disruptions in autism spectrum disorder
por: Doan, Ryan N, et al.
Publicado: (2019)

Shared heritability of attention-deficit/hyperactivity disorder and autism spectrum disorder
por: Rommelse, Nanda N. J., et al.
Publicado: (2010)

Shared Genetic Influences Between Attention-Deficit/Hyperactivity Disorder (ADHD) Traits in Children and Clinical ADHD
por: Stergiakouli, Evie, et al.
Publicado: (2015)

A transcriptome-wide association study implicates specific pre- and post-synaptic abnormalities in schizophrenia
por: Hall, Lynsey S, et al.
Publicado: (2020)

A comparison of four clustering methods for brain expression microarray data
por: Richards, Alexander L, et al.
Publicado: (2008)

Association of Rare Copy Number Variants With Risk of Depression
por: Kendall, Kimberley Marie, et al.
Publicado: (2019)

Autism spectrum disorders and autistic traits share genetics and biology
por: Bralten, J, et al.
Publicado: (2018)

Independence of Hot and Cold Executive Function Deficits in High-Functioning Adults with Autism Spectrum Disorder
por: Zimmerman, David L., et al.
Publicado: (2016)

Cis-effects on gene expression in the human prenatal brain associated with genetic risk for neuropsychiatric disorders
por: Hall, Lynsey S., et al.
Publicado: (2021)

Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants
por: Sanders, Bret, et al.
Publicado: (2022)

Targeted Sequencing of 10,198 Samples Confirms Abnormalities in Neuronal Activity and Implicates Voltage-Gated Sodium Channels in Schizophrenia Pathogenesis
por: Rees, Elliott, et al.
Publicado: (2019)

Disruption of contactin 4 in three subjects with autism spectrum disorder
por: Roohi, J, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_s5acg04idfbmm6kloqeq1b1ls1