Cargando…

Irinotecan and its metabolite SN38 inhibits procollagen I production of dermal fibroblasts from Systemic Sclerosis patients

Systemic sclerosis (SSc) is a rare autoimmune connective tissue disease characterized by a microangiopathy and fibrosis of the skin and internal organs. No treatment has been proved to be efficient in case of early or advanced SSc to prevent or reduce fibrosis. There are strong arguments for a key r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lapoirie, J., Tran, L., Piazza, L., Contin-Bordes, C., Truchetet, M. E., Bonnet, F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8429710/ https://www.ncbi.nlm.nih.gov/pubmed/34504265 http://dx.doi.org/10.1038/s41598-021-97538-3

Ejemplares similares

An EGFR inhibitor enhances the efficacy of SN38, an active metabolite of irinotecan, in SN38-refractory gastric carcinoma cells
por: Yashiro, M, et al.
Publicado: (2011)

Irinotecan metabolite SN38 results in germ cell loss in the testis but not in the ovary of prepubertal mice
por: Lopes, Federica, et al.
Publicado: (2016)

Effective Irinotecan (CPT‐11)‐containing Liposomes: Intraliposomal Conversion to the Active Metabolite SN‐38
por: Sadzuka, Yasuyuki, et al.
Publicado: (1999)

Irinotecan pharmacokinetics-pharmacodynamics: the clinical relevance of prolonged exposure to SN-38
por: Mathijssen, R H J, et al.
Publicado: (2002)

AGEs and Glucose Levels Modulate Type I and III Procollagen mRNA Synthesis in Dermal Fibroblasts Cells Culture
por: Andreea, Serban Iren, et al.
Publicado: (2008)

Th17 cells favor inflammatory responses while inhibiting type I collagen deposition by dermal fibroblasts: differential effects in healthy and systemic sclerosis fibroblasts
por: Brembilla, Nicolò Costantino, et al.
Publicado: (2013)

Molecular characterization of irinotecan (SN-38) resistant human breast cancer cell lines
por: Jandu, Haatisha, et al.
Publicado: (2016)

Chronic Exposure to Rhodobacter Sphaeroides Extract Lycogen™ Prevents UVA-Induced Malondialdehyde Accumulation and Procollagen I Down-Regulation in Human Dermal Fibroblasts
por: Yang, Tsai-Hsiu, et al.
Publicado: (2014)

Fermentation of Panax notoginseng root extract polysaccharides attenuates oxidative stress and promotes type I procollagen synthesis in human dermal fibroblast cells
por: You, Shiquan, et al.
Publicado: (2021)

The potential role of Alu Y in the development of resistance to SN38 (Irinotecan) or oxaliplatin in colorectal cancer
por: Lin, Xue, et al.
Publicado: (2015)

Innate Immunity in Systemic Sclerosis Fibrosis: Recent Advances
por: Laurent, Paoline, et al.
Publicado: (2018)

5-Fluorouracil and irinotecan (SN-38) have limited impact on colon microbial functionality and composition in vitro
por: Vanlancker, Eline, et al.
Publicado: (2017)

Location of procollagen in chick corneal and tendon fibroblasts with ferritin-conjugated antibodies
Publicado: (1975)

Pregnane × Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation
por: Raynal, Caroline, et al.
Publicado: (2010)

Development of a method to quantify total and free irinotecan and 7-ethyl-10-hydroxycamptothecin (SN-38) for pharmacokinetic and bio-distribution studies after administration of irinotecan liposomal formulation
por: Yang, Wenqian, et al.
Publicado: (2019)

Immunocytochemical localization of procollagen and fibronectin in human fibroblasts: effects of the monovalent ionophore, monensin
Publicado: (1980)

Structural Basis for the Acceleration of Procollagen Processing by Procollagen C-Proteinase Enhancer-1
por: Pulido, David, et al.
Publicado: (2018)

Elevated Circulatory Levels of Microparticles Are Associated to Lung Fibrosis and Vasculopathy During Systemic Sclerosis
por: Leleu, Damien, et al.
Publicado: (2020)

Antagonistic Effects of CAPE (a Component of Propolis) on the Cytotoxicity and Genotoxicity of Irinotecan and SN38 in Human Gastrointestinal Cancer Cells In Vitro
por: Gajek, Gabriela, et al.
Publicado: (2020)

Preclinical Activity of Sacituzumab Govitecan, an Antibody-Drug Conjugate Targeting Trophoblast Cell-Surface Antigen 2 (Trop-2) Linked to the Active Metabolite of Irinotecan (SN-38), in Ovarian Cancer
por: Perrone, Emanuele, et al.
Publicado: (2020)

Stepwise proteolytic activation of type I procollagen to collagen within the secretory pathway of tendon fibroblasts in situ
por: Canty-Laird, Elizabeth G., et al.
Publicado: (2011)

Effect of Wubeizi ointment aqueous solution on the expression of type I and III procollagen genes in keloid fibroblasts
por: Zhai, Xiao-Xiang, et al.
Publicado: (2017)

Procollagen C-proteinase Enhancer Stimulates Procollagen Processing by Binding to the C-propeptide Region Only
por: Vadon-Le Goff, Sandrine, et al.
Publicado: (2011)

Giantin is required for intracellular N-terminal processing of type I procollagen
por: Stevenson, Nicola L., et al.
Publicado: (2021)

A Pharmacokinetic and Pharmacodynamic Analysis of CPT‐11 and Its Active Metabolite SN‐38
por: Sasaki, Yasutsuna, et al.
Publicado: (1995)

TGF-β1 upregulates Sar1a expression and induces procollagen-I secretion in hypertrophic scarring fibroblasts
por: Ahn, Keun Jae, et al.
Publicado: (2022)

Bioorthogonal Uncaging of the Active Metabolite of Irinotecan by Palladium‐Functionalized Microdevices
por: Adam, Catherine, et al.
Publicado: (2018)

Correction: Giantin is required for intracellular N-terminal processing of type I procollagen
por: Stevenson, Nicola L., et al.
Publicado: (2021)

A Limited Sampling Model for Estimating Pharmacokinetics of CPT‐11 and Its Metabolite SN‐38
por: Sasaki, Yasutsuna, et al.
Publicado: (1995)

ER-to-Golgi trafficking of procollagen in the absence of large carriers
por: McCaughey, Janine, et al.
Publicado: (2019)

Combined use of irinotecan with histone deacetylase inhibitor belinostat could cause severe toxicity by inhibiting SN-38 glucuronidation via UGT1A1
por: Wang, Lingzhi, et al.
Publicado: (2017)

Immune-Mediated Repair: A Matter of Plasticity
por: Laurent, Paôline, et al.
Publicado: (2017)

COPII-coated membranes function as transport carriers of intracellular procollagen I
por: Gorur, Amita, et al.
Publicado: (2017)

Visualized procollagen Iα1 demonstrates the intracellular processing of propeptides
por: Tanaka, Toshiaki, et al.
Publicado: (2022)

Altered MCM Protein Levels and Autophagic Flux in Aged and Systemic Sclerosis Dermal Fibroblasts
por: Dumit, Verónica I., et al.
Publicado: (2014)

Antifibrotic effect of apremilast in systemic sclerosis dermal fibroblasts and bleomycin-induced mouse model
por: Higuchi, Tomoaki, et al.
Publicado: (2023)

Effects of Bacterial Lysates and Metabolites on Collagen Homeostasis in TNF-α-Challenged Human Dermal Fibroblasts
por: Huuskonen, Laura, et al.
Publicado: (2023)

Investigation into the Efficacy of Val-SN-38, a Valine-Ester Prodrug of the Anti-Cancer Agent SN-38
por: Kwak, Eun-Young, et al.
Publicado: (2012)

Data comparing the kinetics of procollagen type I processing by bone morphogenetic protein 1 (BMP-1) with and without procollagen C-proteinase enhancer 1 (PCPE-1)
por: Moschcovich, Laura, et al.
Publicado: (2016)

CopA3 Peptide Prevents Ultraviolet-Induced Inhibition of Type-I Procollagen and Induction of Matrix Metalloproteinase-1 in Human Skin Fibroblasts
por: Kim, Dong-Hee, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_qr12du8d8jvqsatmd1apr002mq