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Impact of overlapping risks of type 2 diabetes and obesity on coronavirus disease severity in the United States

The impact of overlapping risk factors on coronavirus disease (COVID-19) severity is unclear. To evaluate the impact of type 2 diabetes (T2D) and obesity on COVID-19 severity, we conducted a cohort study with 28,095 anonymized COVID-19 patients using data from the COVID-19 Research Database from Jan...

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Autores principales: Ando, Wataru, Horii, Takeshi, Uematsu, Takayuki, Hanaki, Hideaki, Atsuda, Koichiro, Otori, Katsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8429758/
https://www.ncbi.nlm.nih.gov/pubmed/34504112
http://dx.doi.org/10.1038/s41598-021-96720-x
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author Ando, Wataru
Horii, Takeshi
Uematsu, Takayuki
Hanaki, Hideaki
Atsuda, Koichiro
Otori, Katsuya
author_facet Ando, Wataru
Horii, Takeshi
Uematsu, Takayuki
Hanaki, Hideaki
Atsuda, Koichiro
Otori, Katsuya
author_sort Ando, Wataru
collection PubMed
description The impact of overlapping risk factors on coronavirus disease (COVID-19) severity is unclear. To evaluate the impact of type 2 diabetes (T2D) and obesity on COVID-19 severity, we conducted a cohort study with 28,095 anonymized COVID-19 patients using data from the COVID-19 Research Database from January 1, 2020 to November 30, 2020. The mean age was 50.8 ± 17.5 years, and 11,802 (42%) patients were male. Data on age, race, sex, T2D complications, antidiabetic medication prescription, and body mass index ≥ 30 kg/m(2) (obesity) were analysed using Cox proportional hazard models, with hospitalization risk and critical care within 30 days of COVID-19 diagnosis as the main outcomes. The risk scores were 0–4 for age ≥ 65 years, male sex, T2D, and obesity. Among the participants, 11,294 (61.9%) had obesity, and 4445 (15.8%) had T2D. T2D, obesity, and male sex were significantly associated with COVID-19 hospitalization risk. Regarding hospitalization risk scores, compared with those for hospitalization risk score 0 and critical care risk score 0, hazard ratios [95% confidence intervals] were 19.034 [10.470–34.600] and 55.803 [12.761–244.015] (P < 0.001) (P < 0.001), respectively, for risk score 4. Complications from diabetes and obesity increased hospitalization and critical care risks for COVID-19 patients.
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spelling pubmed-84297582021-09-13 Impact of overlapping risks of type 2 diabetes and obesity on coronavirus disease severity in the United States Ando, Wataru Horii, Takeshi Uematsu, Takayuki Hanaki, Hideaki Atsuda, Koichiro Otori, Katsuya Sci Rep Article The impact of overlapping risk factors on coronavirus disease (COVID-19) severity is unclear. To evaluate the impact of type 2 diabetes (T2D) and obesity on COVID-19 severity, we conducted a cohort study with 28,095 anonymized COVID-19 patients using data from the COVID-19 Research Database from January 1, 2020 to November 30, 2020. The mean age was 50.8 ± 17.5 years, and 11,802 (42%) patients were male. Data on age, race, sex, T2D complications, antidiabetic medication prescription, and body mass index ≥ 30 kg/m(2) (obesity) were analysed using Cox proportional hazard models, with hospitalization risk and critical care within 30 days of COVID-19 diagnosis as the main outcomes. The risk scores were 0–4 for age ≥ 65 years, male sex, T2D, and obesity. Among the participants, 11,294 (61.9%) had obesity, and 4445 (15.8%) had T2D. T2D, obesity, and male sex were significantly associated with COVID-19 hospitalization risk. Regarding hospitalization risk scores, compared with those for hospitalization risk score 0 and critical care risk score 0, hazard ratios [95% confidence intervals] were 19.034 [10.470–34.600] and 55.803 [12.761–244.015] (P < 0.001) (P < 0.001), respectively, for risk score 4. Complications from diabetes and obesity increased hospitalization and critical care risks for COVID-19 patients. Nature Publishing Group UK 2021-09-09 /pmc/articles/PMC8429758/ /pubmed/34504112 http://dx.doi.org/10.1038/s41598-021-96720-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Ando, Wataru
Horii, Takeshi
Uematsu, Takayuki
Hanaki, Hideaki
Atsuda, Koichiro
Otori, Katsuya
Impact of overlapping risks of type 2 diabetes and obesity on coronavirus disease severity in the United States
title Impact of overlapping risks of type 2 diabetes and obesity on coronavirus disease severity in the United States
title_full Impact of overlapping risks of type 2 diabetes and obesity on coronavirus disease severity in the United States
title_fullStr Impact of overlapping risks of type 2 diabetes and obesity on coronavirus disease severity in the United States
title_full_unstemmed Impact of overlapping risks of type 2 diabetes and obesity on coronavirus disease severity in the United States
title_short Impact of overlapping risks of type 2 diabetes and obesity on coronavirus disease severity in the United States
title_sort impact of overlapping risks of type 2 diabetes and obesity on coronavirus disease severity in the united states
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8429758/
https://www.ncbi.nlm.nih.gov/pubmed/34504112
http://dx.doi.org/10.1038/s41598-021-96720-x
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