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Natural Small Molecules Targeting NF-κB Signaling in Glioblastoma

Nuclear factor-κB (NF-κB) is a transcription factor that regulates various genes that mediate various cellular activities, including propagation, differentiation, motility, and survival. Abnormal activation of NF-κB is a common incidence in several cancers. Glioblastoma multiforme (GBM) is the most...

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Autores principales: Uddin, Md. Sahab, Kabir, Md. Tanvir, Mamun, Abdullah Al, Sarwar, Md. Shahid, Nasrin, Fatema, Emran, Talha Bin, Alanazi, Ibtesam S., Rauf, Abdur, Albadrani, Ghadeer M., Sayed, Amany A., Mousa, Shaker A., Abdel-Daim, Mohamed M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8429794/
https://www.ncbi.nlm.nih.gov/pubmed/34512336
http://dx.doi.org/10.3389/fphar.2021.703761
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author Uddin, Md. Sahab
Kabir, Md. Tanvir
Mamun, Abdullah Al
Sarwar, Md. Shahid
Nasrin, Fatema
Emran, Talha Bin
Alanazi, Ibtesam S.
Rauf, Abdur
Albadrani, Ghadeer M.
Sayed, Amany A.
Mousa, Shaker A.
Abdel-Daim, Mohamed M.
author_facet Uddin, Md. Sahab
Kabir, Md. Tanvir
Mamun, Abdullah Al
Sarwar, Md. Shahid
Nasrin, Fatema
Emran, Talha Bin
Alanazi, Ibtesam S.
Rauf, Abdur
Albadrani, Ghadeer M.
Sayed, Amany A.
Mousa, Shaker A.
Abdel-Daim, Mohamed M.
author_sort Uddin, Md. Sahab
collection PubMed
description Nuclear factor-κB (NF-κB) is a transcription factor that regulates various genes that mediate various cellular activities, including propagation, differentiation, motility, and survival. Abnormal activation of NF-κB is a common incidence in several cancers. Glioblastoma multiforme (GBM) is the most aggressive brain cancer described by high cellular heterogeneity and almost unavoidable relapse following surgery and resistance to traditional therapy. In GBM, NF-κB is abnormally activated by various stimuli. Its function has been associated with different processes, including regulation of cancer cells with stem-like phenotypes, invasion of cancer cells, and radiotherapy resistance identification of mesenchymal cells. Even though multimodal therapeutic approaches such as surgery, radiation therapy, and chemotherapeutic drugs are used for treating GBM, however; the estimated mortality rate for GBM patients is around 1 year. Therefore, it is necessary to find out new therapeutic approaches for treating GBM. Many studies are focusing on therapeutics having less adverse effects owing to the failure of conventional chemotherapy and targeted agents. Several studies of compounds suggested the involvement of NF-κB signaling pathways in the growth and development of a tumor and GBM cell apoptosis. In this review, we highlight the involvement of NF-κB signaling in the molecular understanding of GBM and natural compounds targeting NF-κB signaling.
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spelling pubmed-84297942021-09-11 Natural Small Molecules Targeting NF-κB Signaling in Glioblastoma Uddin, Md. Sahab Kabir, Md. Tanvir Mamun, Abdullah Al Sarwar, Md. Shahid Nasrin, Fatema Emran, Talha Bin Alanazi, Ibtesam S. Rauf, Abdur Albadrani, Ghadeer M. Sayed, Amany A. Mousa, Shaker A. Abdel-Daim, Mohamed M. Front Pharmacol Pharmacology Nuclear factor-κB (NF-κB) is a transcription factor that regulates various genes that mediate various cellular activities, including propagation, differentiation, motility, and survival. Abnormal activation of NF-κB is a common incidence in several cancers. Glioblastoma multiforme (GBM) is the most aggressive brain cancer described by high cellular heterogeneity and almost unavoidable relapse following surgery and resistance to traditional therapy. In GBM, NF-κB is abnormally activated by various stimuli. Its function has been associated with different processes, including regulation of cancer cells with stem-like phenotypes, invasion of cancer cells, and radiotherapy resistance identification of mesenchymal cells. Even though multimodal therapeutic approaches such as surgery, radiation therapy, and chemotherapeutic drugs are used for treating GBM, however; the estimated mortality rate for GBM patients is around 1 year. Therefore, it is necessary to find out new therapeutic approaches for treating GBM. Many studies are focusing on therapeutics having less adverse effects owing to the failure of conventional chemotherapy and targeted agents. Several studies of compounds suggested the involvement of NF-κB signaling pathways in the growth and development of a tumor and GBM cell apoptosis. In this review, we highlight the involvement of NF-κB signaling in the molecular understanding of GBM and natural compounds targeting NF-κB signaling. Frontiers Media S.A. 2021-08-27 /pmc/articles/PMC8429794/ /pubmed/34512336 http://dx.doi.org/10.3389/fphar.2021.703761 Text en Copyright © 2021 Uddin, Kabir, Mamun, Sarwar, Nasrin, Emran, Alanazi, Rauf, Albadrani, Sayed, Mousa and Abdel-Daim. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Uddin, Md. Sahab
Kabir, Md. Tanvir
Mamun, Abdullah Al
Sarwar, Md. Shahid
Nasrin, Fatema
Emran, Talha Bin
Alanazi, Ibtesam S.
Rauf, Abdur
Albadrani, Ghadeer M.
Sayed, Amany A.
Mousa, Shaker A.
Abdel-Daim, Mohamed M.
Natural Small Molecules Targeting NF-κB Signaling in Glioblastoma
title Natural Small Molecules Targeting NF-κB Signaling in Glioblastoma
title_full Natural Small Molecules Targeting NF-κB Signaling in Glioblastoma
title_fullStr Natural Small Molecules Targeting NF-κB Signaling in Glioblastoma
title_full_unstemmed Natural Small Molecules Targeting NF-κB Signaling in Glioblastoma
title_short Natural Small Molecules Targeting NF-κB Signaling in Glioblastoma
title_sort natural small molecules targeting nf-κb signaling in glioblastoma
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8429794/
https://www.ncbi.nlm.nih.gov/pubmed/34512336
http://dx.doi.org/10.3389/fphar.2021.703761
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