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Secretory Phospholipase A2s in Insulin Resistance and Metabolism

The phospholipases A(2) (PLA(2)) superfamily encompasses enzymes commonly found in mammalian tissues and snake venom. Many of these enzymes have unique tissue distribution, function, and substrate specificity suggesting distinct biological roles. In the past, much of the research on secretory PLA(2)...

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Autor principal: Kuefner, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8429832/
https://www.ncbi.nlm.nih.gov/pubmed/34512555
http://dx.doi.org/10.3389/fendo.2021.732726
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author Kuefner, Michael S.
author_facet Kuefner, Michael S.
author_sort Kuefner, Michael S.
collection PubMed
description The phospholipases A(2) (PLA(2)) superfamily encompasses enzymes commonly found in mammalian tissues and snake venom. Many of these enzymes have unique tissue distribution, function, and substrate specificity suggesting distinct biological roles. In the past, much of the research on secretory PLA(2)s has analyzed their roles in inflammation, anti-bacterial actions, and atherosclerosis. In recent studies utilizing a variety of mouse models, pancreatic islets, and clinical trials, a role for many of these enzymes in the control of metabolism and insulin action has been revealed. In this review, this research, and the unique contributions of the PLA(2) enzymes in insulin resistance and metabolism.
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spelling pubmed-84298322021-09-11 Secretory Phospholipase A2s in Insulin Resistance and Metabolism Kuefner, Michael S. Front Endocrinol (Lausanne) Endocrinology The phospholipases A(2) (PLA(2)) superfamily encompasses enzymes commonly found in mammalian tissues and snake venom. Many of these enzymes have unique tissue distribution, function, and substrate specificity suggesting distinct biological roles. In the past, much of the research on secretory PLA(2)s has analyzed their roles in inflammation, anti-bacterial actions, and atherosclerosis. In recent studies utilizing a variety of mouse models, pancreatic islets, and clinical trials, a role for many of these enzymes in the control of metabolism and insulin action has been revealed. In this review, this research, and the unique contributions of the PLA(2) enzymes in insulin resistance and metabolism. Frontiers Media S.A. 2021-08-27 /pmc/articles/PMC8429832/ /pubmed/34512555 http://dx.doi.org/10.3389/fendo.2021.732726 Text en Copyright © 2021 Kuefner https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Kuefner, Michael S.
Secretory Phospholipase A2s in Insulin Resistance and Metabolism
title Secretory Phospholipase A2s in Insulin Resistance and Metabolism
title_full Secretory Phospholipase A2s in Insulin Resistance and Metabolism
title_fullStr Secretory Phospholipase A2s in Insulin Resistance and Metabolism
title_full_unstemmed Secretory Phospholipase A2s in Insulin Resistance and Metabolism
title_short Secretory Phospholipase A2s in Insulin Resistance and Metabolism
title_sort secretory phospholipase a2s in insulin resistance and metabolism
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8429832/
https://www.ncbi.nlm.nih.gov/pubmed/34512555
http://dx.doi.org/10.3389/fendo.2021.732726
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