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Secretory Phospholipase A2s in Insulin Resistance and Metabolism
The phospholipases A(2) (PLA(2)) superfamily encompasses enzymes commonly found in mammalian tissues and snake venom. Many of these enzymes have unique tissue distribution, function, and substrate specificity suggesting distinct biological roles. In the past, much of the research on secretory PLA(2)...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8429832/ https://www.ncbi.nlm.nih.gov/pubmed/34512555 http://dx.doi.org/10.3389/fendo.2021.732726 |
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author | Kuefner, Michael S. |
author_facet | Kuefner, Michael S. |
author_sort | Kuefner, Michael S. |
collection | PubMed |
description | The phospholipases A(2) (PLA(2)) superfamily encompasses enzymes commonly found in mammalian tissues and snake venom. Many of these enzymes have unique tissue distribution, function, and substrate specificity suggesting distinct biological roles. In the past, much of the research on secretory PLA(2)s has analyzed their roles in inflammation, anti-bacterial actions, and atherosclerosis. In recent studies utilizing a variety of mouse models, pancreatic islets, and clinical trials, a role for many of these enzymes in the control of metabolism and insulin action has been revealed. In this review, this research, and the unique contributions of the PLA(2) enzymes in insulin resistance and metabolism. |
format | Online Article Text |
id | pubmed-8429832 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84298322021-09-11 Secretory Phospholipase A2s in Insulin Resistance and Metabolism Kuefner, Michael S. Front Endocrinol (Lausanne) Endocrinology The phospholipases A(2) (PLA(2)) superfamily encompasses enzymes commonly found in mammalian tissues and snake venom. Many of these enzymes have unique tissue distribution, function, and substrate specificity suggesting distinct biological roles. In the past, much of the research on secretory PLA(2)s has analyzed their roles in inflammation, anti-bacterial actions, and atherosclerosis. In recent studies utilizing a variety of mouse models, pancreatic islets, and clinical trials, a role for many of these enzymes in the control of metabolism and insulin action has been revealed. In this review, this research, and the unique contributions of the PLA(2) enzymes in insulin resistance and metabolism. Frontiers Media S.A. 2021-08-27 /pmc/articles/PMC8429832/ /pubmed/34512555 http://dx.doi.org/10.3389/fendo.2021.732726 Text en Copyright © 2021 Kuefner https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Kuefner, Michael S. Secretory Phospholipase A2s in Insulin Resistance and Metabolism |
title | Secretory Phospholipase A2s in Insulin Resistance and Metabolism |
title_full | Secretory Phospholipase A2s in Insulin Resistance and Metabolism |
title_fullStr | Secretory Phospholipase A2s in Insulin Resistance and Metabolism |
title_full_unstemmed | Secretory Phospholipase A2s in Insulin Resistance and Metabolism |
title_short | Secretory Phospholipase A2s in Insulin Resistance and Metabolism |
title_sort | secretory phospholipase a2s in insulin resistance and metabolism |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8429832/ https://www.ncbi.nlm.nih.gov/pubmed/34512555 http://dx.doi.org/10.3389/fendo.2021.732726 |
work_keys_str_mv | AT kuefnermichaels secretoryphospholipasea2sininsulinresistanceandmetabolism |