Cargando…

Elevated Expression and Activity of Sodium Leak Channel Contributes to Neuronal Sensitization of Inflammatory Pain in Rats

Inflammatory pain encompasses many clinical symptoms, and there is no satisfactory therapeutic target. Neuronal hyperexcitability and/or sensitization of the primary nociceptive neurons in the dorsal root ganglion (DRG) and spinal dorsal horn are critical to the development and maintenance of inflam...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Jia, Chen, Yali, Liu, Jin, Zhang, Donghang, Liang, Peng, Lu, Peilin, Shen, Jiefei, Miao, Changhong, Zuo, Yunxia, Zhou, Cheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8430348/ https://www.ncbi.nlm.nih.gov/pubmed/34512260 http://dx.doi.org/10.3389/fnmol.2021.723395

Ejemplares similares

Sodium Leak Channel in Glutamatergic Neurons of the Lateral Parabrachial Nucleus Modulates Inflammatory Pain in Mice
por: Wu, Lin, et al.
Publicado: (2023)

Sodium Leak Channel in the Nucleus Accumbens Modulates Ethanol-Induced Acute Stimulant Responses and Locomotor Sensitization in Mice: A Brief Research Report
por: Wu, Yujie, et al.
Publicado: (2021)

Contributions of the Sodium Leak Channel NALCN to Pacemaking of Medial Ventral Tegmental Area and Substantia Nigra Dopaminergic Neurons
por: Cobb-Lewis, Dana E., et al.
Publicado: (2023)

The sodium leak channel, NALCN, in health and disease
por: Cochet-Bissuel, Maud, et al.
Publicado: (2014)

Metabolomics and Whole-Exome Sequencing in Patients with Differential Sensitivity to Sevoflurane: A Protocol for a Prospective Observational Trial
por: Wei, Yiyong, et al.
Publicado: (2021)

G(i/o) protein-coupled receptors in dopamine neurons inhibit the sodium leak channel NALCN
por: Philippart, Fabian, et al.
Publicado: (2018)

The leak channel NALCN controls tonic firing and glycolytic sensitivity of substantia nigra pars reticulata neurons
por: Lutas, Andrew, et al.
Publicado: (2016)

Structure of the human sodium leak channel NALCN in complex with FAM155A
por: Xie, Jiongfang, et al.
Publicado: (2020)

Malignant currents: sodium leak channel NALCN propels prostate cancer aggressiveness
por: Stejerean‐Todoran, Ioana, et al.
Publicado: (2023)

Genomewide association study in cervical dystonia demonstrates possible association with sodium leak channel
por: Mok, Kin Y, et al.
Publicado: (2014)

Sodium leak through K2P potassium channels and cardiac arrhythmia, an emerging theme
por: Goldstein, Steve AN
Publicado: (2017)

Slow Inactivation of Sodium Channels Contributes to Short-Term Adaptation in Vomeronasal Sensory Neurons
por: Sarno, Nicole, et al.
Publicado: (2022)

When the channels leak, the muscle is weak
por: Dove, Alan W.
Publicado: (2003)

Functional Upregulation of Nav1.8 Sodium Channels on the Membrane of Dorsal Root Ganglia Neurons Contributes to the Development of Cancer-Induced Bone Pain
por: Liu, Xiao-Dan, et al.
Publicado: (2014)

Leak detector sensitivity evaluation
por: Hoekemeijer, F
Publicado: (1972)

Colonic Hypersensitivity and Sensitization of Voltage-gated Sodium Channels in Primary Sensory Neurons in Rats with Diabetes
por: Hu, Ji, et al.
Publicado: (2016)

Effects of midazolam, pentobarbital and ketamine on the mRNA expression of ion channels in a model organism Daphnia pulex
por: Dong, Changhong, et al.
Publicado: (2013)

A Proton Leak Current through the Cardiac Sodium Channel Is Linked to Mixed Arrhythmia and the Dilated Cardiomyopathy Phenotype
por: Gosselin-Badaroudine, Pascal, et al.
Publicado: (2012)

Characterization of temperature-sensitive leak K(+) currents and expression of TRAAK, TREK-1, and TREK2 channels in dorsal root ganglion neurons of rats
por: Viatchenko-Karpinski, Viacheslav, et al.
Publicado: (2018)

Amiloride-Sensitive Sodium Channels and Pulmonary Edema
por: Althaus, Mike, et al.
Publicado: (2011)

Methylation determines the extracellular calcium sensitivity of the leak channel NALCN in hippocampal dentate granule cells
por: Lee, Seul-Yi, et al.
Publicado: (2019)

A Sodium Leak Current Regulates Pacemaker Activity of Adult Central Pattern Generator Neurons in Lymnaea Stagnalis
por: Lu, Tom Z., et al.
Publicado: (2011)

Severe deficiency of the voltage-gated sodium channel Na(V)1.2 elevates neuronal excitability in adult mice
por: Zhang, Jingliang, et al.
Publicado: (2021)

Correction: A Proton Leak Current through the Cardiac Sodium Channel Is Linked to Mixed Arrhythmia and the Dilated Cardiomyopathy Phenotype
por: Gosselin-Badaroudine, Pascal, et al.
Publicado: (2012)

A Co-operative Regulation of Neuronal Excitability by UNC-7 Innexin and NCA/NALCN Leak Channel
por: Bouhours, Magali, et al.
Publicado: (2011)

Convergent effects of multiple modulators on two-pore-domain 'leak' potassium channels in respiratory-related neurons
por: Talley, EM, et al.
Publicado: (2001)

A Direct Interaction between Cyclodextrins and TASK Channels Decreases the Leak Current in Cerebellar Granule Neurons
por: Zúñiga, Rafael, et al.
Publicado: (2022)

Elevated CA 125 in a CASE of Leaking Endometrioma
por: Rao, Svetha, et al.
Publicado: (2018)

Despite increasing aldosterone, elevated potassium is not necessary for activating aldosterone‐sensitive HSD2 neurons or sodium appetite
por: Fazan, Frederico S., et al.
Publicado: (2021)

Elevated Neuronal Excitability Due to Modulation of the Voltage-Gated Sodium Channel Nav1.6 by Aβ(1−42)
por: Wang, Xi, et al.
Publicado: (2016)

Leak K(+) channel mRNAs in dorsal root ganglia: Relation to inflammation and spontaneous pain behaviour
por: Marsh, Barnaby, et al.
Publicado: (2012)

Endogenous opioids contribute to insensitivity to pain in humans and mice lacking sodium channel Na(v)1.7
por: Minett, Michael S., et al.
Publicado: (2015)

Gd(3+) and Calcium Sensitive, Sodium Leak Currents Are Features of Weak Membrane-Glass Seals in Patch Clamp Recordings
por: Boone, Adrienne N., et al.
Publicado: (2014)

Propranolol Blocks Cardiac and Neuronal Voltage-Gated Sodium Channels
por: Wang, Dao W., et al.
Publicado: (2010)

Ototrauma induces sodium channel plasticity in auditory afferent neurons
por: Fryatt, Alistair G., et al.
Publicado: (2011)

Reduction of elevated proton leak rejuvenates mitochondria in the aged cardiomyocyte
por: Zhang, Huiliang, et al.
Publicado: (2020)

Reduction of Elevated Proton Leak Rejuvenates Mitochondria in the Aged Cardiomyocyte
por: Zhang, Huiliang, et al.
Publicado: (2020)

Glial interleukin-1β upregulates neuronal sodium channel 1.7 in trigeminal ganglion contributing to temporomandibular joint inflammatory hypernociception in rats
por: Zhang, Peng, et al.
Publicado: (2018)

Stimulation of Epithelial Sodium Channels in Endothelial Cells by Bone Morphogenetic Protein-4 Contributes to Salt-Sensitive Hypertension in Rats
por: Yang, Xu, et al.
Publicado: (2020)

Potential Roles of Amiloride-Sensitive Sodium Channels in Cancer Development
por: Xu, Siguang, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_bipqg54gm5mhcc48ce8s7vtcba