A case of Fournier's gangrene following a large-volume hydrocelectomy in a diabetic patient managed with SGLT-2 inhibitor therapy

Dapagliflozin (Farxiga), is an SGLT-2 inhibitor commonly indicated for the treatment of diabetes mellitus type 2 (DM 2), heart failure, and chronic kidney disease. One rare side effect associated with SGLT-2 inhibitors is bacterial infection of the genitalia. There are several case reports highlight...

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Autores principales: Vargo, Ethan, Leone, Giovanna, Barat, Oren, Yunker, Aaron, Parekh, Neel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Inflammation and Infection
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8430369/
https://www.ncbi.nlm.nih.gov/pubmed/34527517
http://dx.doi.org/10.1016/j.eucr.2021.101834
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author Vargo, Ethan
Leone, Giovanna
Barat, Oren
Yunker, Aaron
Parekh, Neel
author_facet Vargo, Ethan
Leone, Giovanna
Barat, Oren
Yunker, Aaron
Parekh, Neel
author_sort Vargo, Ethan
collection PubMed
description Dapagliflozin (Farxiga), is an SGLT-2 inhibitor commonly indicated for the treatment of diabetes mellitus type 2 (DM 2), heart failure, and chronic kidney disease. One rare side effect associated with SGLT-2 inhibitors is bacterial infection of the genitalia. There are several case reports highlighting the incidence of Fournier's gangrene (FG) in patients who take medications within this drug class. We report a case of FG in a diabetic patient on dapagliflozin who presented following scrotal hydrocelectomy for a large-volume hydrocele. The patient was urgently taken to the operating room for scrotal debridement and recovered well in the post-operative period.
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spelling pubmed-84303692021-09-14 A case of Fournier's gangrene following a large-volume hydrocelectomy in a diabetic patient managed with SGLT-2 inhibitor therapy Vargo, Ethan Leone, Giovanna Barat, Oren Yunker, Aaron Parekh, Neel Urol Case Rep Inflammation and Infection Dapagliflozin (Farxiga), is an SGLT-2 inhibitor commonly indicated for the treatment of diabetes mellitus type 2 (DM 2), heart failure, and chronic kidney disease. One rare side effect associated with SGLT-2 inhibitors is bacterial infection of the genitalia. There are several case reports highlighting the incidence of Fournier's gangrene (FG) in patients who take medications within this drug class. We report a case of FG in a diabetic patient on dapagliflozin who presented following scrotal hydrocelectomy for a large-volume hydrocele. The patient was urgently taken to the operating room for scrotal debridement and recovered well in the post-operative period. Elsevier 2021-09-05 /pmc/articles/PMC8430369/ /pubmed/34527517 http://dx.doi.org/10.1016/j.eucr.2021.101834 Text en © 2021 Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Inflammation and Infection
Vargo, Ethan
Leone, Giovanna
Barat, Oren
Yunker, Aaron
Parekh, Neel
A case of Fournier's gangrene following a large-volume hydrocelectomy in a diabetic patient managed with SGLT-2 inhibitor therapy
title A case of Fournier's gangrene following a large-volume hydrocelectomy in a diabetic patient managed with SGLT-2 inhibitor therapy
title_full A case of Fournier's gangrene following a large-volume hydrocelectomy in a diabetic patient managed with SGLT-2 inhibitor therapy
title_fullStr A case of Fournier's gangrene following a large-volume hydrocelectomy in a diabetic patient managed with SGLT-2 inhibitor therapy
title_full_unstemmed A case of Fournier's gangrene following a large-volume hydrocelectomy in a diabetic patient managed with SGLT-2 inhibitor therapy
title_short A case of Fournier's gangrene following a large-volume hydrocelectomy in a diabetic patient managed with SGLT-2 inhibitor therapy
title_sort case of fournier's gangrene following a large-volume hydrocelectomy in a diabetic patient managed with sglt-2 inhibitor therapy
topic Inflammation and Infection
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8430369/
https://www.ncbi.nlm.nih.gov/pubmed/34527517
http://dx.doi.org/10.1016/j.eucr.2021.101834
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