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Potential Protection of Pre-Existent Antibodies to Human Coronavirus 229E on COVID-19 Severity

The causes of the broad spectrum of severity in COVID-19 are unknown. A protective effect through humoral immunity from previous infections by viruses of the SARS-CoV-2 family could explain a mild form of this disease. This study aimed to address whether the presence of antibodies against human seas...

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Autores principales: Guzmán-Martínez, Oscar, Guardado, Kathia, Varela-Cardoso, Miguel, Trujillo-Rivera, Alejandro, Gómez-Ñañez, Iván, Ortiz-León, María Cristina, Espinosa, Rafaela, Ramos, Celso, Pérez-Carreón, Julio Isael, López-Guerrero, Delia Vanesa, Sampieri, Clara Luz, Alanís-García, Adrián Baruch, Rojas-Durán, Fausto, Zenteno-Cuevas, Roberto, Gutiérrez, Michelle, Montero, Hilda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8430483/
https://www.ncbi.nlm.nih.gov/pubmed/34501647
http://dx.doi.org/10.3390/ijerph18179058
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author Guzmán-Martínez, Oscar
Guardado, Kathia
Varela-Cardoso, Miguel
Trujillo-Rivera, Alejandro
Gómez-Ñañez, Iván
Ortiz-León, María Cristina
Espinosa, Rafaela
Ramos, Celso
Pérez-Carreón, Julio Isael
López-Guerrero, Delia Vanesa
Sampieri, Clara Luz
Alanís-García, Adrián Baruch
Rojas-Durán, Fausto
Zenteno-Cuevas, Roberto
Gutiérrez, Michelle
Montero, Hilda
author_facet Guzmán-Martínez, Oscar
Guardado, Kathia
Varela-Cardoso, Miguel
Trujillo-Rivera, Alejandro
Gómez-Ñañez, Iván
Ortiz-León, María Cristina
Espinosa, Rafaela
Ramos, Celso
Pérez-Carreón, Julio Isael
López-Guerrero, Delia Vanesa
Sampieri, Clara Luz
Alanís-García, Adrián Baruch
Rojas-Durán, Fausto
Zenteno-Cuevas, Roberto
Gutiérrez, Michelle
Montero, Hilda
author_sort Guzmán-Martínez, Oscar
collection PubMed
description The causes of the broad spectrum of severity in COVID-19 are unknown. A protective effect through humoral immunity from previous infections by viruses of the SARS-CoV-2 family could explain a mild form of this disease. This study aimed to address whether the presence of antibodies against human seasonal coronaviruses (HCoVs) could prevent severe manifestations of COVID-19. A cross-sectional study was carried out in 165 participants. The presence of pre-existent antibodies against the seasonal HCoV-OC43, HCoV-HKU1, HCoV-229E, and HCoV-NL63 were detected. From all of the seasonal HCoVs studied, it was only found that being seropositive to HCoV-229E presented an association (p = 0.012) with developing mild clinical symptoms of COVID-19 or being asymptomatic. Multinomial regression analysis showed that being seropositive to HCoV-229E is associated with mild or moderate clinical symptoms for COVID-19. Statistical analysis also showed that being female is associated with being asymptomatic for SARS-CoV-2 infection or developing mild COVID-19. A subgroup analysis taking only seropositive to HCoV-229E revealed that females are more likely to develop asymptomatic SARS-CoV-2 infection (OR = 27.242, 95% CI 2.092–354.706, p = 0.012). Our results suggest that previous infections by HCoV-229E could prevent more serious clinical manifestations of COVID-19, but these are not the only variables that influence this event.
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spelling pubmed-84304832021-09-11 Potential Protection of Pre-Existent Antibodies to Human Coronavirus 229E on COVID-19 Severity Guzmán-Martínez, Oscar Guardado, Kathia Varela-Cardoso, Miguel Trujillo-Rivera, Alejandro Gómez-Ñañez, Iván Ortiz-León, María Cristina Espinosa, Rafaela Ramos, Celso Pérez-Carreón, Julio Isael López-Guerrero, Delia Vanesa Sampieri, Clara Luz Alanís-García, Adrián Baruch Rojas-Durán, Fausto Zenteno-Cuevas, Roberto Gutiérrez, Michelle Montero, Hilda Int J Environ Res Public Health Article The causes of the broad spectrum of severity in COVID-19 are unknown. A protective effect through humoral immunity from previous infections by viruses of the SARS-CoV-2 family could explain a mild form of this disease. This study aimed to address whether the presence of antibodies against human seasonal coronaviruses (HCoVs) could prevent severe manifestations of COVID-19. A cross-sectional study was carried out in 165 participants. The presence of pre-existent antibodies against the seasonal HCoV-OC43, HCoV-HKU1, HCoV-229E, and HCoV-NL63 were detected. From all of the seasonal HCoVs studied, it was only found that being seropositive to HCoV-229E presented an association (p = 0.012) with developing mild clinical symptoms of COVID-19 or being asymptomatic. Multinomial regression analysis showed that being seropositive to HCoV-229E is associated with mild or moderate clinical symptoms for COVID-19. Statistical analysis also showed that being female is associated with being asymptomatic for SARS-CoV-2 infection or developing mild COVID-19. A subgroup analysis taking only seropositive to HCoV-229E revealed that females are more likely to develop asymptomatic SARS-CoV-2 infection (OR = 27.242, 95% CI 2.092–354.706, p = 0.012). Our results suggest that previous infections by HCoV-229E could prevent more serious clinical manifestations of COVID-19, but these are not the only variables that influence this event. MDPI 2021-08-27 /pmc/articles/PMC8430483/ /pubmed/34501647 http://dx.doi.org/10.3390/ijerph18179058 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Guzmán-Martínez, Oscar
Guardado, Kathia
Varela-Cardoso, Miguel
Trujillo-Rivera, Alejandro
Gómez-Ñañez, Iván
Ortiz-León, María Cristina
Espinosa, Rafaela
Ramos, Celso
Pérez-Carreón, Julio Isael
López-Guerrero, Delia Vanesa
Sampieri, Clara Luz
Alanís-García, Adrián Baruch
Rojas-Durán, Fausto
Zenteno-Cuevas, Roberto
Gutiérrez, Michelle
Montero, Hilda
Potential Protection of Pre-Existent Antibodies to Human Coronavirus 229E on COVID-19 Severity
title Potential Protection of Pre-Existent Antibodies to Human Coronavirus 229E on COVID-19 Severity
title_full Potential Protection of Pre-Existent Antibodies to Human Coronavirus 229E on COVID-19 Severity
title_fullStr Potential Protection of Pre-Existent Antibodies to Human Coronavirus 229E on COVID-19 Severity
title_full_unstemmed Potential Protection of Pre-Existent Antibodies to Human Coronavirus 229E on COVID-19 Severity
title_short Potential Protection of Pre-Existent Antibodies to Human Coronavirus 229E on COVID-19 Severity
title_sort potential protection of pre-existent antibodies to human coronavirus 229e on covid-19 severity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8430483/
https://www.ncbi.nlm.nih.gov/pubmed/34501647
http://dx.doi.org/10.3390/ijerph18179058
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