Cargando…

Characteristics of the Passive Muscle Stiffness of the Vastus Lateralis: A Feasibility Study to Assess Muscle Fibrosis

Skeletal muscle fibrosis occurs with aging and has been suggested to impair muscle performance, thereby decreasing quality of life. Recently, muscle stiffness, a surrogate measure of muscle fibrosis, was noninvasively quantified as the shear modulus using ultrasound shear wave elastography (SWE) in...

Descripción completa

Detalles Bibliográficos
Autores principales: Maeda, Akifumi, Yamagishi, Maito, Otsuka, Yuta, Izumo, Takayuki, Rogi, Tomohiro, Shibata, Hiroshi, Fukuda, Masahiro, Arimitsu, Takuma, Yamada, Yosuke, Miyamoto, Naokazu, Hashimoto, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8430484/
https://www.ncbi.nlm.nih.gov/pubmed/34501539
http://dx.doi.org/10.3390/ijerph18178947
_version_ 1783750714220085248
author Maeda, Akifumi
Yamagishi, Maito
Otsuka, Yuta
Izumo, Takayuki
Rogi, Tomohiro
Shibata, Hiroshi
Fukuda, Masahiro
Arimitsu, Takuma
Yamada, Yosuke
Miyamoto, Naokazu
Hashimoto, Takeshi
author_facet Maeda, Akifumi
Yamagishi, Maito
Otsuka, Yuta
Izumo, Takayuki
Rogi, Tomohiro
Shibata, Hiroshi
Fukuda, Masahiro
Arimitsu, Takuma
Yamada, Yosuke
Miyamoto, Naokazu
Hashimoto, Takeshi
author_sort Maeda, Akifumi
collection PubMed
description Skeletal muscle fibrosis occurs with aging and has been suggested to impair muscle performance, thereby decreasing quality of life. Recently, muscle stiffness, a surrogate measure of muscle fibrosis, was noninvasively quantified as the shear modulus using ultrasound shear wave elastography (SWE) in humans. We aimed to investigate thigh muscle stiffness in females and males, respectively, across a broad range of ages by using SWE. Eighty-six community-dwelling Japanese people who were aged 30 to 79 years and did not regularly exercise participated in this study. The vastus lateralis (VL) shear modulus was measured at three different knee joint angles: full extension, 90° of flexion, and full flexion. There were no significant main effects of sex or age on the VL shear modulus in full extension or 90° of flexion of the knee. However, the VL shear modulus in knee full flexion was significantly smaller in females than in males and increased with age from 47.9 years. The results suggest that the accelerated increase in VL stiffness that occurs after an individual passes their late 40s may be an important therapeutic target for developing effective treatments and programs that preserve and improve quality of life.
format Online
Article
Text
id pubmed-8430484
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-84304842021-09-11 Characteristics of the Passive Muscle Stiffness of the Vastus Lateralis: A Feasibility Study to Assess Muscle Fibrosis Maeda, Akifumi Yamagishi, Maito Otsuka, Yuta Izumo, Takayuki Rogi, Tomohiro Shibata, Hiroshi Fukuda, Masahiro Arimitsu, Takuma Yamada, Yosuke Miyamoto, Naokazu Hashimoto, Takeshi Int J Environ Res Public Health Article Skeletal muscle fibrosis occurs with aging and has been suggested to impair muscle performance, thereby decreasing quality of life. Recently, muscle stiffness, a surrogate measure of muscle fibrosis, was noninvasively quantified as the shear modulus using ultrasound shear wave elastography (SWE) in humans. We aimed to investigate thigh muscle stiffness in females and males, respectively, across a broad range of ages by using SWE. Eighty-six community-dwelling Japanese people who were aged 30 to 79 years and did not regularly exercise participated in this study. The vastus lateralis (VL) shear modulus was measured at three different knee joint angles: full extension, 90° of flexion, and full flexion. There were no significant main effects of sex or age on the VL shear modulus in full extension or 90° of flexion of the knee. However, the VL shear modulus in knee full flexion was significantly smaller in females than in males and increased with age from 47.9 years. The results suggest that the accelerated increase in VL stiffness that occurs after an individual passes their late 40s may be an important therapeutic target for developing effective treatments and programs that preserve and improve quality of life. MDPI 2021-08-25 /pmc/articles/PMC8430484/ /pubmed/34501539 http://dx.doi.org/10.3390/ijerph18178947 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Maeda, Akifumi
Yamagishi, Maito
Otsuka, Yuta
Izumo, Takayuki
Rogi, Tomohiro
Shibata, Hiroshi
Fukuda, Masahiro
Arimitsu, Takuma
Yamada, Yosuke
Miyamoto, Naokazu
Hashimoto, Takeshi
Characteristics of the Passive Muscle Stiffness of the Vastus Lateralis: A Feasibility Study to Assess Muscle Fibrosis
title Characteristics of the Passive Muscle Stiffness of the Vastus Lateralis: A Feasibility Study to Assess Muscle Fibrosis
title_full Characteristics of the Passive Muscle Stiffness of the Vastus Lateralis: A Feasibility Study to Assess Muscle Fibrosis
title_fullStr Characteristics of the Passive Muscle Stiffness of the Vastus Lateralis: A Feasibility Study to Assess Muscle Fibrosis
title_full_unstemmed Characteristics of the Passive Muscle Stiffness of the Vastus Lateralis: A Feasibility Study to Assess Muscle Fibrosis
title_short Characteristics of the Passive Muscle Stiffness of the Vastus Lateralis: A Feasibility Study to Assess Muscle Fibrosis
title_sort characteristics of the passive muscle stiffness of the vastus lateralis: a feasibility study to assess muscle fibrosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8430484/
https://www.ncbi.nlm.nih.gov/pubmed/34501539
http://dx.doi.org/10.3390/ijerph18178947
work_keys_str_mv AT maedaakifumi characteristicsofthepassivemusclestiffnessofthevastuslateralisafeasibilitystudytoassessmusclefibrosis
AT yamagishimaito characteristicsofthepassivemusclestiffnessofthevastuslateralisafeasibilitystudytoassessmusclefibrosis
AT otsukayuta characteristicsofthepassivemusclestiffnessofthevastuslateralisafeasibilitystudytoassessmusclefibrosis
AT izumotakayuki characteristicsofthepassivemusclestiffnessofthevastuslateralisafeasibilitystudytoassessmusclefibrosis
AT rogitomohiro characteristicsofthepassivemusclestiffnessofthevastuslateralisafeasibilitystudytoassessmusclefibrosis
AT shibatahiroshi characteristicsofthepassivemusclestiffnessofthevastuslateralisafeasibilitystudytoassessmusclefibrosis
AT fukudamasahiro characteristicsofthepassivemusclestiffnessofthevastuslateralisafeasibilitystudytoassessmusclefibrosis
AT arimitsutakuma characteristicsofthepassivemusclestiffnessofthevastuslateralisafeasibilitystudytoassessmusclefibrosis
AT yamadayosuke characteristicsofthepassivemusclestiffnessofthevastuslateralisafeasibilitystudytoassessmusclefibrosis
AT miyamotonaokazu characteristicsofthepassivemusclestiffnessofthevastuslateralisafeasibilitystudytoassessmusclefibrosis
AT hashimototakeshi characteristicsofthepassivemusclestiffnessofthevastuslateralisafeasibilitystudytoassessmusclefibrosis