Cargando…

Melatonin Inhibits Osteoclastogenesis and Osteolytic Bone Metastasis: Implications for Osteoporosis

Osteoblasts and osteoclasts are major cellular components in the bone microenvironment and they play a key role in the bone turnover cycle. Many risk factors interfere with this cycle and contribute to bone-wasting diseases that progressively destroy bone and markedly reduce quality of life. Melaton...

Descripción completa

Detalles Bibliográficos
Autores principales: MacDonald, Iona J., Tsai, Hsiao-Chi, Chang, An-Chen, Huang, Chien-Chung, Yang, Shun-Fa, Tang, Chih-Hsin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8430520/
https://www.ncbi.nlm.nih.gov/pubmed/34502344
http://dx.doi.org/10.3390/ijms22179435
_version_ 1783750722649587712
author MacDonald, Iona J.
Tsai, Hsiao-Chi
Chang, An-Chen
Huang, Chien-Chung
Yang, Shun-Fa
Tang, Chih-Hsin
author_facet MacDonald, Iona J.
Tsai, Hsiao-Chi
Chang, An-Chen
Huang, Chien-Chung
Yang, Shun-Fa
Tang, Chih-Hsin
author_sort MacDonald, Iona J.
collection PubMed
description Osteoblasts and osteoclasts are major cellular components in the bone microenvironment and they play a key role in the bone turnover cycle. Many risk factors interfere with this cycle and contribute to bone-wasting diseases that progressively destroy bone and markedly reduce quality of life. Melatonin (N-acetyl-5-methoxy-tryptamine) has demonstrated intriguing therapeutic potential in the bone microenvironment, with reported effects that include the regulation of bone metabolism, acceleration of osteoblastogenesis, inhibition of osteoclastogenesis and the induction of apoptosis in mature osteoclasts, as well as the suppression of osteolytic bone metastasis. This review aims to shed light on molecular and clinical evidence that points to possibilities of melatonin for the treatment of both osteoporosis and osteolytic bone metastasis. It appears that the therapeutic qualities of melatonin supplementation may enable existing antiresorptive osteoporotic drugs to treat osteolytic metastasis.
format Online
Article
Text
id pubmed-8430520
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-84305202021-09-11 Melatonin Inhibits Osteoclastogenesis and Osteolytic Bone Metastasis: Implications for Osteoporosis MacDonald, Iona J. Tsai, Hsiao-Chi Chang, An-Chen Huang, Chien-Chung Yang, Shun-Fa Tang, Chih-Hsin Int J Mol Sci Review Osteoblasts and osteoclasts are major cellular components in the bone microenvironment and they play a key role in the bone turnover cycle. Many risk factors interfere with this cycle and contribute to bone-wasting diseases that progressively destroy bone and markedly reduce quality of life. Melatonin (N-acetyl-5-methoxy-tryptamine) has demonstrated intriguing therapeutic potential in the bone microenvironment, with reported effects that include the regulation of bone metabolism, acceleration of osteoblastogenesis, inhibition of osteoclastogenesis and the induction of apoptosis in mature osteoclasts, as well as the suppression of osteolytic bone metastasis. This review aims to shed light on molecular and clinical evidence that points to possibilities of melatonin for the treatment of both osteoporosis and osteolytic bone metastasis. It appears that the therapeutic qualities of melatonin supplementation may enable existing antiresorptive osteoporotic drugs to treat osteolytic metastasis. MDPI 2021-08-30 /pmc/articles/PMC8430520/ /pubmed/34502344 http://dx.doi.org/10.3390/ijms22179435 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
MacDonald, Iona J.
Tsai, Hsiao-Chi
Chang, An-Chen
Huang, Chien-Chung
Yang, Shun-Fa
Tang, Chih-Hsin
Melatonin Inhibits Osteoclastogenesis and Osteolytic Bone Metastasis: Implications for Osteoporosis
title Melatonin Inhibits Osteoclastogenesis and Osteolytic Bone Metastasis: Implications for Osteoporosis
title_full Melatonin Inhibits Osteoclastogenesis and Osteolytic Bone Metastasis: Implications for Osteoporosis
title_fullStr Melatonin Inhibits Osteoclastogenesis and Osteolytic Bone Metastasis: Implications for Osteoporosis
title_full_unstemmed Melatonin Inhibits Osteoclastogenesis and Osteolytic Bone Metastasis: Implications for Osteoporosis
title_short Melatonin Inhibits Osteoclastogenesis and Osteolytic Bone Metastasis: Implications for Osteoporosis
title_sort melatonin inhibits osteoclastogenesis and osteolytic bone metastasis: implications for osteoporosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8430520/
https://www.ncbi.nlm.nih.gov/pubmed/34502344
http://dx.doi.org/10.3390/ijms22179435
work_keys_str_mv AT macdonaldionaj melatonininhibitsosteoclastogenesisandosteolyticbonemetastasisimplicationsforosteoporosis
AT tsaihsiaochi melatonininhibitsosteoclastogenesisandosteolyticbonemetastasisimplicationsforosteoporosis
AT changanchen melatonininhibitsosteoclastogenesisandosteolyticbonemetastasisimplicationsforosteoporosis
AT huangchienchung melatonininhibitsosteoclastogenesisandosteolyticbonemetastasisimplicationsforosteoporosis
AT yangshunfa melatonininhibitsosteoclastogenesisandosteolyticbonemetastasisimplicationsforosteoporosis
AT tangchihhsin melatonininhibitsosteoclastogenesisandosteolyticbonemetastasisimplicationsforosteoporosis