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Development, Diversity, and Death of MGE-Derived Cortical Interneurons
In the mammalian brain, cortical interneurons (INs) are a highly diverse group of cells. A key neurophysiological question concerns how each class of INs contributes to cortical circuit function and whether specific roles can be attributed to a selective cell type. To address this question, research...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8430628/ https://www.ncbi.nlm.nih.gov/pubmed/34502208 http://dx.doi.org/10.3390/ijms22179297 |
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author | Williams, Rhîannan H. Riedemann, Therese |
author_facet | Williams, Rhîannan H. Riedemann, Therese |
author_sort | Williams, Rhîannan H. |
collection | PubMed |
description | In the mammalian brain, cortical interneurons (INs) are a highly diverse group of cells. A key neurophysiological question concerns how each class of INs contributes to cortical circuit function and whether specific roles can be attributed to a selective cell type. To address this question, researchers are integrating knowledge derived from transcriptomic, histological, electrophysiological, developmental, and functional experiments to extensively characterise the different classes of INs. Our hope is that such knowledge permits the selective targeting of cell types for therapeutic endeavours. This review will focus on two of the main types of INs, namely the parvalbumin (PV(+)) or somatostatin (SOM(+))-containing cells, and summarise the research to date on these classes. |
format | Online Article Text |
id | pubmed-8430628 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84306282021-09-11 Development, Diversity, and Death of MGE-Derived Cortical Interneurons Williams, Rhîannan H. Riedemann, Therese Int J Mol Sci Review In the mammalian brain, cortical interneurons (INs) are a highly diverse group of cells. A key neurophysiological question concerns how each class of INs contributes to cortical circuit function and whether specific roles can be attributed to a selective cell type. To address this question, researchers are integrating knowledge derived from transcriptomic, histological, electrophysiological, developmental, and functional experiments to extensively characterise the different classes of INs. Our hope is that such knowledge permits the selective targeting of cell types for therapeutic endeavours. This review will focus on two of the main types of INs, namely the parvalbumin (PV(+)) or somatostatin (SOM(+))-containing cells, and summarise the research to date on these classes. MDPI 2021-08-27 /pmc/articles/PMC8430628/ /pubmed/34502208 http://dx.doi.org/10.3390/ijms22179297 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Williams, Rhîannan H. Riedemann, Therese Development, Diversity, and Death of MGE-Derived Cortical Interneurons |
title | Development, Diversity, and Death of MGE-Derived Cortical Interneurons |
title_full | Development, Diversity, and Death of MGE-Derived Cortical Interneurons |
title_fullStr | Development, Diversity, and Death of MGE-Derived Cortical Interneurons |
title_full_unstemmed | Development, Diversity, and Death of MGE-Derived Cortical Interneurons |
title_short | Development, Diversity, and Death of MGE-Derived Cortical Interneurons |
title_sort | development, diversity, and death of mge-derived cortical interneurons |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8430628/ https://www.ncbi.nlm.nih.gov/pubmed/34502208 http://dx.doi.org/10.3390/ijms22179297 |
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