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Development, Diversity, and Death of MGE-Derived Cortical Interneurons

In the mammalian brain, cortical interneurons (INs) are a highly diverse group of cells. A key neurophysiological question concerns how each class of INs contributes to cortical circuit function and whether specific roles can be attributed to a selective cell type. To address this question, research...

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Detalles Bibliográficos
Autores principales: Williams, Rhîannan H., Riedemann, Therese
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8430628/
https://www.ncbi.nlm.nih.gov/pubmed/34502208
http://dx.doi.org/10.3390/ijms22179297
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author Williams, Rhîannan H.
Riedemann, Therese
author_facet Williams, Rhîannan H.
Riedemann, Therese
author_sort Williams, Rhîannan H.
collection PubMed
description In the mammalian brain, cortical interneurons (INs) are a highly diverse group of cells. A key neurophysiological question concerns how each class of INs contributes to cortical circuit function and whether specific roles can be attributed to a selective cell type. To address this question, researchers are integrating knowledge derived from transcriptomic, histological, electrophysiological, developmental, and functional experiments to extensively characterise the different classes of INs. Our hope is that such knowledge permits the selective targeting of cell types for therapeutic endeavours. This review will focus on two of the main types of INs, namely the parvalbumin (PV(+)) or somatostatin (SOM(+))-containing cells, and summarise the research to date on these classes.
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spelling pubmed-84306282021-09-11 Development, Diversity, and Death of MGE-Derived Cortical Interneurons Williams, Rhîannan H. Riedemann, Therese Int J Mol Sci Review In the mammalian brain, cortical interneurons (INs) are a highly diverse group of cells. A key neurophysiological question concerns how each class of INs contributes to cortical circuit function and whether specific roles can be attributed to a selective cell type. To address this question, researchers are integrating knowledge derived from transcriptomic, histological, electrophysiological, developmental, and functional experiments to extensively characterise the different classes of INs. Our hope is that such knowledge permits the selective targeting of cell types for therapeutic endeavours. This review will focus on two of the main types of INs, namely the parvalbumin (PV(+)) or somatostatin (SOM(+))-containing cells, and summarise the research to date on these classes. MDPI 2021-08-27 /pmc/articles/PMC8430628/ /pubmed/34502208 http://dx.doi.org/10.3390/ijms22179297 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Williams, Rhîannan H.
Riedemann, Therese
Development, Diversity, and Death of MGE-Derived Cortical Interneurons
title Development, Diversity, and Death of MGE-Derived Cortical Interneurons
title_full Development, Diversity, and Death of MGE-Derived Cortical Interneurons
title_fullStr Development, Diversity, and Death of MGE-Derived Cortical Interneurons
title_full_unstemmed Development, Diversity, and Death of MGE-Derived Cortical Interneurons
title_short Development, Diversity, and Death of MGE-Derived Cortical Interneurons
title_sort development, diversity, and death of mge-derived cortical interneurons
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8430628/
https://www.ncbi.nlm.nih.gov/pubmed/34502208
http://dx.doi.org/10.3390/ijms22179297
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