A Truncated NRIP1 Mutant Amplifies Microsatellite Instability of Colorectal Cancer by Regulating MSH2/MSH6 Expression, and Is a Prognostic Marker of Stage III Tumors

SIMPLE SUMMARY: The alteration of mismatch repair (MMR) genes leads to microsatellite instability and plays a key role in colorectal cancer (CRC) pathogenesis and prognosis. The transcription factor NRIP1 is involved in intestinal tumorigenesis and is a good prognostic marker in CRC. In this study,...

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Autores principales: Palassin, Pascale, Lapierre, Marion, Pyrdziak, Samuel, Wagner, Antoine, Stehle, Régine, Corsini, Carole, Duffour, Jacqueline, Bonnet, Sandrine, Boulahtouf, Abdelhay, Rodriguez, Carmen, Ho-Pun-Cheung, Alexandre, Lopez-Crapez, Evelyne, Boissière-Michot, Florence, Bibeau, Frédéric, Thezenas, Simon, Elarouci, Nabila, Selves, Janick, Hoffmann, Jean-Sébastien, Roepman, Paul, Mazard, Thibault, Buhard, Olivier, Duval, Alex, Jalaguier, Stéphan, Cavaillès, Vincent, Castet-Nicolas, Audrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8430632/
https://www.ncbi.nlm.nih.gov/pubmed/34503257
http://dx.doi.org/10.3390/cancers13174449

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