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Cannabinoids and Endocannabinoid System Changes in Intestinal Inflammation and Colorectal Cancer

SIMPLE SUMMARY: In recent years, multiple preclinical studies have shown that changes in endocannabinoid system signaling may have various effects on intestinal inflammation and colorectal cancer. However, not all tumors can respond to cannabinoid therapy in the same manner. Given that colorectal ca...

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Autores principales: Cherkasova, Viktoriia, Kovalchuk, Olga, Kovalchuk, Igor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8430689/
https://www.ncbi.nlm.nih.gov/pubmed/34503163
http://dx.doi.org/10.3390/cancers13174353
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author Cherkasova, Viktoriia
Kovalchuk, Olga
Kovalchuk, Igor
author_facet Cherkasova, Viktoriia
Kovalchuk, Olga
Kovalchuk, Igor
author_sort Cherkasova, Viktoriia
collection PubMed
description SIMPLE SUMMARY: In recent years, multiple preclinical studies have shown that changes in endocannabinoid system signaling may have various effects on intestinal inflammation and colorectal cancer. However, not all tumors can respond to cannabinoid therapy in the same manner. Given that colorectal cancer is a heterogeneous disease with different genomic landscapes, experiments with cannabinoids should involve different molecular subtypes, emerging mutations, and various stages of the disease. We hope that this review can help researchers form a comprehensive understanding of cannabinoid interactions in colorectal cancer and intestinal bowel diseases. We believe that selecting a particular experimental model based on the disease’s genetic landscape is a crucial step in the drug discovery, which eventually may tremendously benefit patient’s treatment outcomes and bring us one step closer to individualized medicine. ABSTRACT: Despite the multiple preventive measures and treatment options, colorectal cancer holds a significant place in the world’s disease and mortality rates. The development of novel therapy is in critical need, and based on recent experimental data, cannabinoids could become excellent candidates. This review covered known experimental studies regarding the effects of cannabinoids on intestinal inflammation and colorectal cancer. In our opinion, because colorectal cancer is a heterogeneous disease with different genomic landscapes, the choice of cannabinoids for tumor prevention and treatment depends on the type of the disease, its etiology, driver mutations, and the expression levels of cannabinoid receptors. In this review, we describe the molecular changes of the endocannabinoid system in the pathologies of the large intestine, focusing on inflammation and cancer.
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spelling pubmed-84306892021-09-11 Cannabinoids and Endocannabinoid System Changes in Intestinal Inflammation and Colorectal Cancer Cherkasova, Viktoriia Kovalchuk, Olga Kovalchuk, Igor Cancers (Basel) Review SIMPLE SUMMARY: In recent years, multiple preclinical studies have shown that changes in endocannabinoid system signaling may have various effects on intestinal inflammation and colorectal cancer. However, not all tumors can respond to cannabinoid therapy in the same manner. Given that colorectal cancer is a heterogeneous disease with different genomic landscapes, experiments with cannabinoids should involve different molecular subtypes, emerging mutations, and various stages of the disease. We hope that this review can help researchers form a comprehensive understanding of cannabinoid interactions in colorectal cancer and intestinal bowel diseases. We believe that selecting a particular experimental model based on the disease’s genetic landscape is a crucial step in the drug discovery, which eventually may tremendously benefit patient’s treatment outcomes and bring us one step closer to individualized medicine. ABSTRACT: Despite the multiple preventive measures and treatment options, colorectal cancer holds a significant place in the world’s disease and mortality rates. The development of novel therapy is in critical need, and based on recent experimental data, cannabinoids could become excellent candidates. This review covered known experimental studies regarding the effects of cannabinoids on intestinal inflammation and colorectal cancer. In our opinion, because colorectal cancer is a heterogeneous disease with different genomic landscapes, the choice of cannabinoids for tumor prevention and treatment depends on the type of the disease, its etiology, driver mutations, and the expression levels of cannabinoid receptors. In this review, we describe the molecular changes of the endocannabinoid system in the pathologies of the large intestine, focusing on inflammation and cancer. MDPI 2021-08-28 /pmc/articles/PMC8430689/ /pubmed/34503163 http://dx.doi.org/10.3390/cancers13174353 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cherkasova, Viktoriia
Kovalchuk, Olga
Kovalchuk, Igor
Cannabinoids and Endocannabinoid System Changes in Intestinal Inflammation and Colorectal Cancer
title Cannabinoids and Endocannabinoid System Changes in Intestinal Inflammation and Colorectal Cancer
title_full Cannabinoids and Endocannabinoid System Changes in Intestinal Inflammation and Colorectal Cancer
title_fullStr Cannabinoids and Endocannabinoid System Changes in Intestinal Inflammation and Colorectal Cancer
title_full_unstemmed Cannabinoids and Endocannabinoid System Changes in Intestinal Inflammation and Colorectal Cancer
title_short Cannabinoids and Endocannabinoid System Changes in Intestinal Inflammation and Colorectal Cancer
title_sort cannabinoids and endocannabinoid system changes in intestinal inflammation and colorectal cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8430689/
https://www.ncbi.nlm.nih.gov/pubmed/34503163
http://dx.doi.org/10.3390/cancers13174353
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