Charge-Transfer Interactions Stabilize G-Quadruplex-Forming Thrombin Binding Aptamers and Can Improve Their Anticoagulant Activity

In the search for optimized thrombin binding aptamers (TBAs), we herein describe the synthesis of a library of TBA analogues obtained by end-functionalization with the electron-rich 1,5-dialkoxy naphthalene (DAN) and the electron-deficient 1,8,4,5-naphthalenetetra-carboxylic diimide (NDI) moieties....

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Detalles Bibliográficos
Autores principales: Pérez de Carvasal, Kévan, Riccardi, Claudia, Russo Krauss, Irene, Cavasso, Domenico, Vasseur, Jean-Jacques, Smietana, Michael, Morvan, François, Montesarchio, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8430690/
https://www.ncbi.nlm.nih.gov/pubmed/34502432
http://dx.doi.org/10.3390/ijms22179510

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