Dual Targeting of EGFR with PLK1 Exerts Therapeutic Synergism in Taxane-Resistant Lung Adenocarcinoma by Suppressing ABC Transporters

SIMPLE SUMMARY: Our previous studies led us to hypothesize that downregulation of PLK1 expression or its activity can overcome the hurdles of taxane resistance by downregulating ABC transporters. Targeting PLK1 with shRNA or non-functional mutants downregulated ABCB1, ABCC9, and ABCG2 in paclitaxel-...

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Detalles Bibliográficos
Autores principales: Shin, Sol-Bi, Kim, Dae-Hoon, Kim, Da-Eun, Aldonza, Mark Borris D., Kim, Yoosik, Yim, Hyungshin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8430738/
https://www.ncbi.nlm.nih.gov/pubmed/34503223
http://dx.doi.org/10.3390/cancers13174413

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8430738/
https://www.ncbi.nlm.nih.gov/pubmed/34503223
http://dx.doi.org/10.3390/cancers13174413

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