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Key Points in Remote-Controlled Drug Delivery: From the Carrier Design to Clinical Trials

The increased research activity aiming at improved delivery of pharmaceutical molecules indicates the expansion of the field. An efficient therapeutic delivery approach is based on the optimal choice of drug-carrying vehicle, successful targeting, and payload release enabling the site-specific accum...

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Autores principales: Voronin, Denis V., Abalymov, Anatolii A., Svenskaya, Yulia I., Lomova, Maria V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8430748/
https://www.ncbi.nlm.nih.gov/pubmed/34502059
http://dx.doi.org/10.3390/ijms22179149
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author Voronin, Denis V.
Abalymov, Anatolii A.
Svenskaya, Yulia I.
Lomova, Maria V.
author_facet Voronin, Denis V.
Abalymov, Anatolii A.
Svenskaya, Yulia I.
Lomova, Maria V.
author_sort Voronin, Denis V.
collection PubMed
description The increased research activity aiming at improved delivery of pharmaceutical molecules indicates the expansion of the field. An efficient therapeutic delivery approach is based on the optimal choice of drug-carrying vehicle, successful targeting, and payload release enabling the site-specific accumulation of the therapeutic molecules. However, designing the formulation endowed with the targeting properties in vitro does not guarantee its selective delivery in vivo. The various biological barriers that the carrier encounters upon intravascular administration should be adequately addressed in its overall design to reduce the off-target effects and unwanted toxicity in vivo and thereby enhance the therapeutic efficacy of the payload. Here, we discuss the main parameters of remote-controlled drug delivery systems: (i) key principles of the carrier selection; (ii) the most significant physiological barriers and limitations associated with the drug delivery; (iii) major concepts for its targeting and cargo release stimulation by external stimuli in vivo. The clinical translation for drug delivery systems is also described along with the main challenges, key parameters, and examples of successfully translated drug delivery platforms. The essential steps on the way from drug delivery system design to clinical trials are summarized, arranged, and discussed.
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spelling pubmed-84307482021-09-11 Key Points in Remote-Controlled Drug Delivery: From the Carrier Design to Clinical Trials Voronin, Denis V. Abalymov, Anatolii A. Svenskaya, Yulia I. Lomova, Maria V. Int J Mol Sci Review The increased research activity aiming at improved delivery of pharmaceutical molecules indicates the expansion of the field. An efficient therapeutic delivery approach is based on the optimal choice of drug-carrying vehicle, successful targeting, and payload release enabling the site-specific accumulation of the therapeutic molecules. However, designing the formulation endowed with the targeting properties in vitro does not guarantee its selective delivery in vivo. The various biological barriers that the carrier encounters upon intravascular administration should be adequately addressed in its overall design to reduce the off-target effects and unwanted toxicity in vivo and thereby enhance the therapeutic efficacy of the payload. Here, we discuss the main parameters of remote-controlled drug delivery systems: (i) key principles of the carrier selection; (ii) the most significant physiological barriers and limitations associated with the drug delivery; (iii) major concepts for its targeting and cargo release stimulation by external stimuli in vivo. The clinical translation for drug delivery systems is also described along with the main challenges, key parameters, and examples of successfully translated drug delivery platforms. The essential steps on the way from drug delivery system design to clinical trials are summarized, arranged, and discussed. MDPI 2021-08-24 /pmc/articles/PMC8430748/ /pubmed/34502059 http://dx.doi.org/10.3390/ijms22179149 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Voronin, Denis V.
Abalymov, Anatolii A.
Svenskaya, Yulia I.
Lomova, Maria V.
Key Points in Remote-Controlled Drug Delivery: From the Carrier Design to Clinical Trials
title Key Points in Remote-Controlled Drug Delivery: From the Carrier Design to Clinical Trials
title_full Key Points in Remote-Controlled Drug Delivery: From the Carrier Design to Clinical Trials
title_fullStr Key Points in Remote-Controlled Drug Delivery: From the Carrier Design to Clinical Trials
title_full_unstemmed Key Points in Remote-Controlled Drug Delivery: From the Carrier Design to Clinical Trials
title_short Key Points in Remote-Controlled Drug Delivery: From the Carrier Design to Clinical Trials
title_sort key points in remote-controlled drug delivery: from the carrier design to clinical trials
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8430748/
https://www.ncbi.nlm.nih.gov/pubmed/34502059
http://dx.doi.org/10.3390/ijms22179149
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