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Neuroprotection Mediated by Human Blood Plasma in Mouse Hippocampal Slice Cultures and in Oxidatively Stressed Human Neurons
Neuroprotection from oxidative stress is critical during neuronal development and maintenance but also plays a major role in the pathogenesis and potential treatment of various neurological disorders and neurodegenerative diseases. Emerging evidence in the murine system suggests neuroprotective effe...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8430756/ https://www.ncbi.nlm.nih.gov/pubmed/34502475 http://dx.doi.org/10.3390/ijms22179567 |
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author | Ruiz-Perera, Lucia M. Höving, Anna L. Schmidt, Kazuko E. Cenan, Sule Wohllebe, Max Greiner, Johannes F. W. Kaltschmidt, Christian Simon, Matthias Knabbe, Cornelius Kaltschmidt, Barbara |
author_facet | Ruiz-Perera, Lucia M. Höving, Anna L. Schmidt, Kazuko E. Cenan, Sule Wohllebe, Max Greiner, Johannes F. W. Kaltschmidt, Christian Simon, Matthias Knabbe, Cornelius Kaltschmidt, Barbara |
author_sort | Ruiz-Perera, Lucia M. |
collection | PubMed |
description | Neuroprotection from oxidative stress is critical during neuronal development and maintenance but also plays a major role in the pathogenesis and potential treatment of various neurological disorders and neurodegenerative diseases. Emerging evidence in the murine system suggests neuroprotective effects of blood plasma on the aged or diseased brain. However, little is known about plasma-mediated effects on human neurons. In the present study, we demonstrate the neuroprotective effect mediated by human plasma and the most abundant plasma–protein human serum albumin against oxidative stress in glutamatergic neurons differentiated from human neural crest-derived inferior turbinate stem cells. We observed a strong neuroprotective effect of human plasma and human serum albumin against oxidative stress-induced neuronal death on the single cell level, similar to the one mediated by tumor necrosis factor alpha. Moreover, we detected neuroprotection of plasma and human serum albumin against kainic acid-induced excitatory stress in ex vivo cultured mouse hippocampal tissue slices. The present study provides deeper insights into plasma-mediated neuroprotection ultimately resulting in the development of novel therapies for a variety of neurological and, in particular, neurodegenerative diseases. |
format | Online Article Text |
id | pubmed-8430756 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84307562021-09-11 Neuroprotection Mediated by Human Blood Plasma in Mouse Hippocampal Slice Cultures and in Oxidatively Stressed Human Neurons Ruiz-Perera, Lucia M. Höving, Anna L. Schmidt, Kazuko E. Cenan, Sule Wohllebe, Max Greiner, Johannes F. W. Kaltschmidt, Christian Simon, Matthias Knabbe, Cornelius Kaltschmidt, Barbara Int J Mol Sci Communication Neuroprotection from oxidative stress is critical during neuronal development and maintenance but also plays a major role in the pathogenesis and potential treatment of various neurological disorders and neurodegenerative diseases. Emerging evidence in the murine system suggests neuroprotective effects of blood plasma on the aged or diseased brain. However, little is known about plasma-mediated effects on human neurons. In the present study, we demonstrate the neuroprotective effect mediated by human plasma and the most abundant plasma–protein human serum albumin against oxidative stress in glutamatergic neurons differentiated from human neural crest-derived inferior turbinate stem cells. We observed a strong neuroprotective effect of human plasma and human serum albumin against oxidative stress-induced neuronal death on the single cell level, similar to the one mediated by tumor necrosis factor alpha. Moreover, we detected neuroprotection of plasma and human serum albumin against kainic acid-induced excitatory stress in ex vivo cultured mouse hippocampal tissue slices. The present study provides deeper insights into plasma-mediated neuroprotection ultimately resulting in the development of novel therapies for a variety of neurological and, in particular, neurodegenerative diseases. MDPI 2021-09-03 /pmc/articles/PMC8430756/ /pubmed/34502475 http://dx.doi.org/10.3390/ijms22179567 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Ruiz-Perera, Lucia M. Höving, Anna L. Schmidt, Kazuko E. Cenan, Sule Wohllebe, Max Greiner, Johannes F. W. Kaltschmidt, Christian Simon, Matthias Knabbe, Cornelius Kaltschmidt, Barbara Neuroprotection Mediated by Human Blood Plasma in Mouse Hippocampal Slice Cultures and in Oxidatively Stressed Human Neurons |
title | Neuroprotection Mediated by Human Blood Plasma in Mouse Hippocampal Slice Cultures and in Oxidatively Stressed Human Neurons |
title_full | Neuroprotection Mediated by Human Blood Plasma in Mouse Hippocampal Slice Cultures and in Oxidatively Stressed Human Neurons |
title_fullStr | Neuroprotection Mediated by Human Blood Plasma in Mouse Hippocampal Slice Cultures and in Oxidatively Stressed Human Neurons |
title_full_unstemmed | Neuroprotection Mediated by Human Blood Plasma in Mouse Hippocampal Slice Cultures and in Oxidatively Stressed Human Neurons |
title_short | Neuroprotection Mediated by Human Blood Plasma in Mouse Hippocampal Slice Cultures and in Oxidatively Stressed Human Neurons |
title_sort | neuroprotection mediated by human blood plasma in mouse hippocampal slice cultures and in oxidatively stressed human neurons |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8430756/ https://www.ncbi.nlm.nih.gov/pubmed/34502475 http://dx.doi.org/10.3390/ijms22179567 |
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