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Cellular Defensive Mechanisms of Tea Polyphenols: Structure-Activity Relationship

Tea is particularly rich in polyphenols, including catechins and theaflavins, thearubigins, flavonols, and phenolic acids, which are believed to contribute to the health benefits of tea. The health-promoting effects of tea polyphenols are believed to be related to their cellular defensive properties...

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Detalles Bibliográficos
Autores principales: Truong, Van-Long, Jeong, Woo-Sik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8430757/
https://www.ncbi.nlm.nih.gov/pubmed/34502017
http://dx.doi.org/10.3390/ijms22179109
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author Truong, Van-Long
Jeong, Woo-Sik
author_facet Truong, Van-Long
Jeong, Woo-Sik
author_sort Truong, Van-Long
collection PubMed
description Tea is particularly rich in polyphenols, including catechins and theaflavins, thearubigins, flavonols, and phenolic acids, which are believed to contribute to the health benefits of tea. The health-promoting effects of tea polyphenols are believed to be related to their cellular defensive properties. This review is intended to briefly summarize the relationship between the chemical structures of tea polyphenols and their biological activities. Tea polyphenols appear as direct antioxidants by scavenging reactive oxygen/nitrogen species; chelating transition metals; and inhibiting lipid, protein, and DNA oxidations. They also act directly by suppressing “pro-oxidant” enzymes, inducing endogenous antioxidants, and cooperating with vitamins. Moreover, tea polyphenols regulate cellular signaling transduction pathways, importantly contributing to the prevention of chronic diseases and the promotion of physiological functions. Apparently, the features in the chemical structures of tea polyphenols are closely associated with their antioxidant potentials.
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spelling pubmed-84307572021-09-11 Cellular Defensive Mechanisms of Tea Polyphenols: Structure-Activity Relationship Truong, Van-Long Jeong, Woo-Sik Int J Mol Sci Review Tea is particularly rich in polyphenols, including catechins and theaflavins, thearubigins, flavonols, and phenolic acids, which are believed to contribute to the health benefits of tea. The health-promoting effects of tea polyphenols are believed to be related to their cellular defensive properties. This review is intended to briefly summarize the relationship between the chemical structures of tea polyphenols and their biological activities. Tea polyphenols appear as direct antioxidants by scavenging reactive oxygen/nitrogen species; chelating transition metals; and inhibiting lipid, protein, and DNA oxidations. They also act directly by suppressing “pro-oxidant” enzymes, inducing endogenous antioxidants, and cooperating with vitamins. Moreover, tea polyphenols regulate cellular signaling transduction pathways, importantly contributing to the prevention of chronic diseases and the promotion of physiological functions. Apparently, the features in the chemical structures of tea polyphenols are closely associated with their antioxidant potentials. MDPI 2021-08-24 /pmc/articles/PMC8430757/ /pubmed/34502017 http://dx.doi.org/10.3390/ijms22179109 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Truong, Van-Long
Jeong, Woo-Sik
Cellular Defensive Mechanisms of Tea Polyphenols: Structure-Activity Relationship
title Cellular Defensive Mechanisms of Tea Polyphenols: Structure-Activity Relationship
title_full Cellular Defensive Mechanisms of Tea Polyphenols: Structure-Activity Relationship
title_fullStr Cellular Defensive Mechanisms of Tea Polyphenols: Structure-Activity Relationship
title_full_unstemmed Cellular Defensive Mechanisms of Tea Polyphenols: Structure-Activity Relationship
title_short Cellular Defensive Mechanisms of Tea Polyphenols: Structure-Activity Relationship
title_sort cellular defensive mechanisms of tea polyphenols: structure-activity relationship
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8430757/
https://www.ncbi.nlm.nih.gov/pubmed/34502017
http://dx.doi.org/10.3390/ijms22179109
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