Cargando…
Multiplicity of Glycosphingolipid-Enriched Microdomain-Driven Immune Signaling
Glycosphingolipids (GSLs), together with cholesterol, sphingomyelin (SM), and glycosylphosphatidylinositol (GPI)-anchored and membrane-associated signal transduction molecules, form GSL-enriched microdomains. These specialized microdomains interact in a cis manner with various immune receptors, affe...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8430928/ https://www.ncbi.nlm.nih.gov/pubmed/34502474 http://dx.doi.org/10.3390/ijms22179565 |
_version_ | 1783750818073149440 |
---|---|
author | Yokoyama, Noriko Hanafusa, Kei Hotta, Tomomi Oshima, Eriko Iwabuchi, Kazuhisa Nakayama, Hitoshi |
author_facet | Yokoyama, Noriko Hanafusa, Kei Hotta, Tomomi Oshima, Eriko Iwabuchi, Kazuhisa Nakayama, Hitoshi |
author_sort | Yokoyama, Noriko |
collection | PubMed |
description | Glycosphingolipids (GSLs), together with cholesterol, sphingomyelin (SM), and glycosylphosphatidylinositol (GPI)-anchored and membrane-associated signal transduction molecules, form GSL-enriched microdomains. These specialized microdomains interact in a cis manner with various immune receptors, affecting immune receptor-mediated signaling. This, in turn, results in the regulation of a broad range of immunological functions, including phagocytosis, cytokine production, antigen presentation and apoptosis. In addition, GSLs alone can regulate immunological functions by acting as ligands for immune receptors, and exogenous GSLs can alter the organization of microdomains and microdomain-associated signaling. Many pathogens, including viruses, bacteria and fungi, enter host cells by binding to GSL-enriched microdomains. Intracellular pathogens survive inside phagocytes by manipulating intracellular microdomain-driven signaling and/or sphingolipid metabolism pathways. This review describes the mechanisms by which GSL-enriched microdomains regulate immune signaling. |
format | Online Article Text |
id | pubmed-8430928 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84309282021-09-11 Multiplicity of Glycosphingolipid-Enriched Microdomain-Driven Immune Signaling Yokoyama, Noriko Hanafusa, Kei Hotta, Tomomi Oshima, Eriko Iwabuchi, Kazuhisa Nakayama, Hitoshi Int J Mol Sci Review Glycosphingolipids (GSLs), together with cholesterol, sphingomyelin (SM), and glycosylphosphatidylinositol (GPI)-anchored and membrane-associated signal transduction molecules, form GSL-enriched microdomains. These specialized microdomains interact in a cis manner with various immune receptors, affecting immune receptor-mediated signaling. This, in turn, results in the regulation of a broad range of immunological functions, including phagocytosis, cytokine production, antigen presentation and apoptosis. In addition, GSLs alone can regulate immunological functions by acting as ligands for immune receptors, and exogenous GSLs can alter the organization of microdomains and microdomain-associated signaling. Many pathogens, including viruses, bacteria and fungi, enter host cells by binding to GSL-enriched microdomains. Intracellular pathogens survive inside phagocytes by manipulating intracellular microdomain-driven signaling and/or sphingolipid metabolism pathways. This review describes the mechanisms by which GSL-enriched microdomains regulate immune signaling. MDPI 2021-09-03 /pmc/articles/PMC8430928/ /pubmed/34502474 http://dx.doi.org/10.3390/ijms22179565 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Yokoyama, Noriko Hanafusa, Kei Hotta, Tomomi Oshima, Eriko Iwabuchi, Kazuhisa Nakayama, Hitoshi Multiplicity of Glycosphingolipid-Enriched Microdomain-Driven Immune Signaling |
title | Multiplicity of Glycosphingolipid-Enriched Microdomain-Driven Immune Signaling |
title_full | Multiplicity of Glycosphingolipid-Enriched Microdomain-Driven Immune Signaling |
title_fullStr | Multiplicity of Glycosphingolipid-Enriched Microdomain-Driven Immune Signaling |
title_full_unstemmed | Multiplicity of Glycosphingolipid-Enriched Microdomain-Driven Immune Signaling |
title_short | Multiplicity of Glycosphingolipid-Enriched Microdomain-Driven Immune Signaling |
title_sort | multiplicity of glycosphingolipid-enriched microdomain-driven immune signaling |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8430928/ https://www.ncbi.nlm.nih.gov/pubmed/34502474 http://dx.doi.org/10.3390/ijms22179565 |
work_keys_str_mv | AT yokoyamanoriko multiplicityofglycosphingolipidenrichedmicrodomaindrivenimmunesignaling AT hanafusakei multiplicityofglycosphingolipidenrichedmicrodomaindrivenimmunesignaling AT hottatomomi multiplicityofglycosphingolipidenrichedmicrodomaindrivenimmunesignaling AT oshimaeriko multiplicityofglycosphingolipidenrichedmicrodomaindrivenimmunesignaling AT iwabuchikazuhisa multiplicityofglycosphingolipidenrichedmicrodomaindrivenimmunesignaling AT nakayamahitoshi multiplicityofglycosphingolipidenrichedmicrodomaindrivenimmunesignaling |