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Air Pollution, Residential Greenness and Metabolic Dysfunction during Early Pregnancy in the INfancia y Medio Ambiente (INMA) Cohort

Despite extensive study, the role of air pollution in gestational diabetes remains unclear, and there is limited evidence of the beneficial impact of residential greenness on metabolic dysfunction during pregnancy. We used data from mothers in the Spanish INfancia y Medio Ambiente (INMA) Project fro...

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Autores principales: Rammah, Amal, Whitworth, Kristina W., Amos, Christopher I., Estarlich, Marisa, Guxens, Mònica, Ibarluzea, Jesús, Iñiguez, Carmen, Subiza-Pérez, Mikel, Vrijheid, Martine, Symanski, Elaine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8430971/
https://www.ncbi.nlm.nih.gov/pubmed/34501944
http://dx.doi.org/10.3390/ijerph18179354
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author Rammah, Amal
Whitworth, Kristina W.
Amos, Christopher I.
Estarlich, Marisa
Guxens, Mònica
Ibarluzea, Jesús
Iñiguez, Carmen
Subiza-Pérez, Mikel
Vrijheid, Martine
Symanski, Elaine
author_facet Rammah, Amal
Whitworth, Kristina W.
Amos, Christopher I.
Estarlich, Marisa
Guxens, Mònica
Ibarluzea, Jesús
Iñiguez, Carmen
Subiza-Pérez, Mikel
Vrijheid, Martine
Symanski, Elaine
author_sort Rammah, Amal
collection PubMed
description Despite extensive study, the role of air pollution in gestational diabetes remains unclear, and there is limited evidence of the beneficial impact of residential greenness on metabolic dysfunction during pregnancy. We used data from mothers in the Spanish INfancia y Medio Ambiente (INMA) Project from 2003–2008. We obtained spatiotemporally resolved estimates of fine particulate matter (PM(2.5)) and nitrogen dioxide (NO(2)) exposures in early pregnancy and estimated residential greenness using satellite-based Normal Difference Vegetation Index (NDVI) within 100, 300 and 500 m buffers surrounding the mother’s residence. We applied logistic regression models to evaluate associations between each of the three exposures of interest and (a) glucose intolerance and (b) abnormal lipid levels. We found limited evidence of associations between increases in PM(2.5) and NO(2) exposures and the metabolic outcomes. Though not statistically significant, high PM(2.5) exposure (≥25 µg/m(3)) was associated with increased odds of glucose intolerance (OR = 1.16, 95% CI: 0.82, 1.63) and high cholesterol (OR = 1.14, 95% CI: 0.90, 1.44). High NO(2) exposure (≥39.8 µg/m(3)) was inversely associated with odds of high triglycerides (OR = 0.70, 95% CI: 0.45, 1.08). Whereas NDVI was not associated with glucose intolerance, odds of high triglycerides were increased, although the results were highly imprecise. Results were unchanged when the air pollutant variables were included in the regression models. Given the equivocal findings in our study, additional investigations are needed to assess effects of air pollution and residential greenness on metabolic dysfunction during pregnancy.
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spelling pubmed-84309712021-09-11 Air Pollution, Residential Greenness and Metabolic Dysfunction during Early Pregnancy in the INfancia y Medio Ambiente (INMA) Cohort Rammah, Amal Whitworth, Kristina W. Amos, Christopher I. Estarlich, Marisa Guxens, Mònica Ibarluzea, Jesús Iñiguez, Carmen Subiza-Pérez, Mikel Vrijheid, Martine Symanski, Elaine Int J Environ Res Public Health Article Despite extensive study, the role of air pollution in gestational diabetes remains unclear, and there is limited evidence of the beneficial impact of residential greenness on metabolic dysfunction during pregnancy. We used data from mothers in the Spanish INfancia y Medio Ambiente (INMA) Project from 2003–2008. We obtained spatiotemporally resolved estimates of fine particulate matter (PM(2.5)) and nitrogen dioxide (NO(2)) exposures in early pregnancy and estimated residential greenness using satellite-based Normal Difference Vegetation Index (NDVI) within 100, 300 and 500 m buffers surrounding the mother’s residence. We applied logistic regression models to evaluate associations between each of the three exposures of interest and (a) glucose intolerance and (b) abnormal lipid levels. We found limited evidence of associations between increases in PM(2.5) and NO(2) exposures and the metabolic outcomes. Though not statistically significant, high PM(2.5) exposure (≥25 µg/m(3)) was associated with increased odds of glucose intolerance (OR = 1.16, 95% CI: 0.82, 1.63) and high cholesterol (OR = 1.14, 95% CI: 0.90, 1.44). High NO(2) exposure (≥39.8 µg/m(3)) was inversely associated with odds of high triglycerides (OR = 0.70, 95% CI: 0.45, 1.08). Whereas NDVI was not associated with glucose intolerance, odds of high triglycerides were increased, although the results were highly imprecise. Results were unchanged when the air pollutant variables were included in the regression models. Given the equivocal findings in our study, additional investigations are needed to assess effects of air pollution and residential greenness on metabolic dysfunction during pregnancy. MDPI 2021-09-04 /pmc/articles/PMC8430971/ /pubmed/34501944 http://dx.doi.org/10.3390/ijerph18179354 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rammah, Amal
Whitworth, Kristina W.
Amos, Christopher I.
Estarlich, Marisa
Guxens, Mònica
Ibarluzea, Jesús
Iñiguez, Carmen
Subiza-Pérez, Mikel
Vrijheid, Martine
Symanski, Elaine
Air Pollution, Residential Greenness and Metabolic Dysfunction during Early Pregnancy in the INfancia y Medio Ambiente (INMA) Cohort
title Air Pollution, Residential Greenness and Metabolic Dysfunction during Early Pregnancy in the INfancia y Medio Ambiente (INMA) Cohort
title_full Air Pollution, Residential Greenness and Metabolic Dysfunction during Early Pregnancy in the INfancia y Medio Ambiente (INMA) Cohort
title_fullStr Air Pollution, Residential Greenness and Metabolic Dysfunction during Early Pregnancy in the INfancia y Medio Ambiente (INMA) Cohort
title_full_unstemmed Air Pollution, Residential Greenness and Metabolic Dysfunction during Early Pregnancy in the INfancia y Medio Ambiente (INMA) Cohort
title_short Air Pollution, Residential Greenness and Metabolic Dysfunction during Early Pregnancy in the INfancia y Medio Ambiente (INMA) Cohort
title_sort air pollution, residential greenness and metabolic dysfunction during early pregnancy in the infancia y medio ambiente (inma) cohort
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8430971/
https://www.ncbi.nlm.nih.gov/pubmed/34501944
http://dx.doi.org/10.3390/ijerph18179354
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