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Epigenetic Alterations Related to Gestational Diabetes Mellitus

Gestational diabetes mellitus (GDM) is the most common metabolic complication in pregnancy, which affects the future health of both the mother and the newborn. Its pathophysiology involves nutritional, hormonal, immunological, genetic and epigenetic factors. Among the latter, it has been observed th...

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Autores principales: Valencia-Ortega, Jorge, Saucedo, Renata, Sánchez-Rodríguez, Martha A., Cruz-Durán, José G., Martínez, Edgar G. Ramos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8430976/
https://www.ncbi.nlm.nih.gov/pubmed/34502370
http://dx.doi.org/10.3390/ijms22179462
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author Valencia-Ortega, Jorge
Saucedo, Renata
Sánchez-Rodríguez, Martha A.
Cruz-Durán, José G.
Martínez, Edgar G. Ramos
author_facet Valencia-Ortega, Jorge
Saucedo, Renata
Sánchez-Rodríguez, Martha A.
Cruz-Durán, José G.
Martínez, Edgar G. Ramos
author_sort Valencia-Ortega, Jorge
collection PubMed
description Gestational diabetes mellitus (GDM) is the most common metabolic complication in pregnancy, which affects the future health of both the mother and the newborn. Its pathophysiology involves nutritional, hormonal, immunological, genetic and epigenetic factors. Among the latter, it has been observed that alterations in DNA (deoxyribonucleic acid) methylation patterns and in the levels of certain micro RNAs, whether in placenta or adipose tissue, are related to well-known characteristics of the disease, such as hyperglycemia, insulin resistance, inflammation and excessive placental growth. Furthermore, epigenetic alterations of gestational diabetes mellitus are observable in maternal blood, although their pathophysiological roles are completely unknown. Despite this, it has not been possible to determine the causes of the epigenetic characteristics of GDM, highlighting the need for integral and longitudinal studies. Based on this, this article summarizes the most relevant and recent studies on epigenetic alterations in placenta, adipose tissue and maternal blood associated with GDM in order to provide the reader with a general overview of the subject and indicate future research topics.
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spelling pubmed-84309762021-09-11 Epigenetic Alterations Related to Gestational Diabetes Mellitus Valencia-Ortega, Jorge Saucedo, Renata Sánchez-Rodríguez, Martha A. Cruz-Durán, José G. Martínez, Edgar G. Ramos Int J Mol Sci Review Gestational diabetes mellitus (GDM) is the most common metabolic complication in pregnancy, which affects the future health of both the mother and the newborn. Its pathophysiology involves nutritional, hormonal, immunological, genetic and epigenetic factors. Among the latter, it has been observed that alterations in DNA (deoxyribonucleic acid) methylation patterns and in the levels of certain micro RNAs, whether in placenta or adipose tissue, are related to well-known characteristics of the disease, such as hyperglycemia, insulin resistance, inflammation and excessive placental growth. Furthermore, epigenetic alterations of gestational diabetes mellitus are observable in maternal blood, although their pathophysiological roles are completely unknown. Despite this, it has not been possible to determine the causes of the epigenetic characteristics of GDM, highlighting the need for integral and longitudinal studies. Based on this, this article summarizes the most relevant and recent studies on epigenetic alterations in placenta, adipose tissue and maternal blood associated with GDM in order to provide the reader with a general overview of the subject and indicate future research topics. MDPI 2021-08-31 /pmc/articles/PMC8430976/ /pubmed/34502370 http://dx.doi.org/10.3390/ijms22179462 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Valencia-Ortega, Jorge
Saucedo, Renata
Sánchez-Rodríguez, Martha A.
Cruz-Durán, José G.
Martínez, Edgar G. Ramos
Epigenetic Alterations Related to Gestational Diabetes Mellitus
title Epigenetic Alterations Related to Gestational Diabetes Mellitus
title_full Epigenetic Alterations Related to Gestational Diabetes Mellitus
title_fullStr Epigenetic Alterations Related to Gestational Diabetes Mellitus
title_full_unstemmed Epigenetic Alterations Related to Gestational Diabetes Mellitus
title_short Epigenetic Alterations Related to Gestational Diabetes Mellitus
title_sort epigenetic alterations related to gestational diabetes mellitus
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8430976/
https://www.ncbi.nlm.nih.gov/pubmed/34502370
http://dx.doi.org/10.3390/ijms22179462
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