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Does Coenzyme Q10 Supplementation Improve Human Oocyte Quality?
Acquiring oocyte competence requires optimal mitochondrial function and adequate ATP levels. In this context, CoQ10 supplementation may improve human oocyte quality and subsequent reproductive performance given its role in ATP synthesis and mitochondrial protection from ROS oxidative damage. In infe...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431086/ https://www.ncbi.nlm.nih.gov/pubmed/34502447 http://dx.doi.org/10.3390/ijms22179541 |
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author | Rodríguez-Varela, Cristina Labarta, Elena |
author_facet | Rodríguez-Varela, Cristina Labarta, Elena |
author_sort | Rodríguez-Varela, Cristina |
collection | PubMed |
description | Acquiring oocyte competence requires optimal mitochondrial function and adequate ATP levels. In this context, CoQ10 supplementation may improve human oocyte quality and subsequent reproductive performance given its role in ATP synthesis and mitochondrial protection from ROS oxidative damage. In infertility treatments, CoQ10 therapy can be orally supplied to promote a more favorable environment for oocyte development in vivo or by its addition to culture media in an attempt to improve its quality in vitro. Human clinical studies evaluating the impact of CoQ10 on reproductive performance are summarized in this review, although the available data do not clearly prove its ability to improve human oocyte quality. The main objective is to provide readers with a complete overview of this topic’s current status as well as the keys for potential future research lines that may help to take this therapy to clinical practice. Indeed, further clinical trials are needed to confirm these results along with molecular studies to evaluate the impact of CoQ10 supplementation on oxidative stress status and mitochondrial function in human gametes. |
format | Online Article Text |
id | pubmed-8431086 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84310862021-09-11 Does Coenzyme Q10 Supplementation Improve Human Oocyte Quality? Rodríguez-Varela, Cristina Labarta, Elena Int J Mol Sci Review Acquiring oocyte competence requires optimal mitochondrial function and adequate ATP levels. In this context, CoQ10 supplementation may improve human oocyte quality and subsequent reproductive performance given its role in ATP synthesis and mitochondrial protection from ROS oxidative damage. In infertility treatments, CoQ10 therapy can be orally supplied to promote a more favorable environment for oocyte development in vivo or by its addition to culture media in an attempt to improve its quality in vitro. Human clinical studies evaluating the impact of CoQ10 on reproductive performance are summarized in this review, although the available data do not clearly prove its ability to improve human oocyte quality. The main objective is to provide readers with a complete overview of this topic’s current status as well as the keys for potential future research lines that may help to take this therapy to clinical practice. Indeed, further clinical trials are needed to confirm these results along with molecular studies to evaluate the impact of CoQ10 supplementation on oxidative stress status and mitochondrial function in human gametes. MDPI 2021-09-02 /pmc/articles/PMC8431086/ /pubmed/34502447 http://dx.doi.org/10.3390/ijms22179541 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Rodríguez-Varela, Cristina Labarta, Elena Does Coenzyme Q10 Supplementation Improve Human Oocyte Quality? |
title | Does Coenzyme Q10 Supplementation Improve Human Oocyte Quality? |
title_full | Does Coenzyme Q10 Supplementation Improve Human Oocyte Quality? |
title_fullStr | Does Coenzyme Q10 Supplementation Improve Human Oocyte Quality? |
title_full_unstemmed | Does Coenzyme Q10 Supplementation Improve Human Oocyte Quality? |
title_short | Does Coenzyme Q10 Supplementation Improve Human Oocyte Quality? |
title_sort | does coenzyme q10 supplementation improve human oocyte quality? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431086/ https://www.ncbi.nlm.nih.gov/pubmed/34502447 http://dx.doi.org/10.3390/ijms22179541 |
work_keys_str_mv | AT rodriguezvarelacristina doescoenzymeq10supplementationimprovehumanoocytequality AT labartaelena doescoenzymeq10supplementationimprovehumanoocytequality |