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Occupational Exposures to Organic Solvents and Asthma Symptoms in the CONSTANCES Cohort
Solvents are used in many workplaces and may be airway irritants but few studies have examined their association with asthma. We studied this question in CONSTANCES (cohort of ‘CONSulTANts des Centres d’Examens de Santé’), a large French cohort. Current asthma and asthma symptom scores were defined...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431091/ https://www.ncbi.nlm.nih.gov/pubmed/34501848 http://dx.doi.org/10.3390/ijerph18179258 |
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author | Sit, Guillaume Letellier, Noémie Iwatsubo, Yuriko Goldberg, Marcel Leynaert, Bénédicte Nadif, Rachel Ribet, Céline Roche, Nicolas Roquelaure, Yves Varraso, Raphaëlle Zins, Marie Descatha, Alexis Le Moual, Nicole Dumas, Orianne |
author_facet | Sit, Guillaume Letellier, Noémie Iwatsubo, Yuriko Goldberg, Marcel Leynaert, Bénédicte Nadif, Rachel Ribet, Céline Roche, Nicolas Roquelaure, Yves Varraso, Raphaëlle Zins, Marie Descatha, Alexis Le Moual, Nicole Dumas, Orianne |
author_sort | Sit, Guillaume |
collection | PubMed |
description | Solvents are used in many workplaces and may be airway irritants but few studies have examined their association with asthma. We studied this question in CONSTANCES (cohort of ‘CONSulTANts des Centres d’Examens de Santé’), a large French cohort. Current asthma and asthma symptom scores were defined by participant-reported respiratory symptoms, asthma medication or attacks, and the sum of 5 symptoms, in the past 12 months, respectively. Lifetime exposures to 5 organic solvents, paints and inks were assessed by questionnaire and a population-based Job-Exposure Matrix (JEM). Cross-sectional associations between exposures and outcomes were evaluated by gender using logistic and negative binomial regressions adjusted for age, smoking habits and body mass index. Analyses included 115,757 adults (54% women, mean age 47 years, 9% current asthma). Self-reported exposure to ≥1 solvent was significantly associated with current asthma in men and women, whereas using the JEM, a significant association was observed only in women. Significant associations between exposures to ≥1 solvent and asthma symptom score were observed for both self-report (mean score ratio, 95%CI, women: 1.36, 1.31–1.42; men: 1.34, 1.30–1.40) and JEM (women: 1.10, 1.07–1.15; men: 1.14, 1.09–1.18). Exposure to specific solvents was significantly associated with higher asthma symptom score. Occupational exposure to solvents should be systematically sought when caring for asthma. |
format | Online Article Text |
id | pubmed-8431091 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84310912021-09-11 Occupational Exposures to Organic Solvents and Asthma Symptoms in the CONSTANCES Cohort Sit, Guillaume Letellier, Noémie Iwatsubo, Yuriko Goldberg, Marcel Leynaert, Bénédicte Nadif, Rachel Ribet, Céline Roche, Nicolas Roquelaure, Yves Varraso, Raphaëlle Zins, Marie Descatha, Alexis Le Moual, Nicole Dumas, Orianne Int J Environ Res Public Health Article Solvents are used in many workplaces and may be airway irritants but few studies have examined their association with asthma. We studied this question in CONSTANCES (cohort of ‘CONSulTANts des Centres d’Examens de Santé’), a large French cohort. Current asthma and asthma symptom scores were defined by participant-reported respiratory symptoms, asthma medication or attacks, and the sum of 5 symptoms, in the past 12 months, respectively. Lifetime exposures to 5 organic solvents, paints and inks were assessed by questionnaire and a population-based Job-Exposure Matrix (JEM). Cross-sectional associations between exposures and outcomes were evaluated by gender using logistic and negative binomial regressions adjusted for age, smoking habits and body mass index. Analyses included 115,757 adults (54% women, mean age 47 years, 9% current asthma). Self-reported exposure to ≥1 solvent was significantly associated with current asthma in men and women, whereas using the JEM, a significant association was observed only in women. Significant associations between exposures to ≥1 solvent and asthma symptom score were observed for both self-report (mean score ratio, 95%CI, women: 1.36, 1.31–1.42; men: 1.34, 1.30–1.40) and JEM (women: 1.10, 1.07–1.15; men: 1.14, 1.09–1.18). Exposure to specific solvents was significantly associated with higher asthma symptom score. Occupational exposure to solvents should be systematically sought when caring for asthma. MDPI 2021-09-02 /pmc/articles/PMC8431091/ /pubmed/34501848 http://dx.doi.org/10.3390/ijerph18179258 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sit, Guillaume Letellier, Noémie Iwatsubo, Yuriko Goldberg, Marcel Leynaert, Bénédicte Nadif, Rachel Ribet, Céline Roche, Nicolas Roquelaure, Yves Varraso, Raphaëlle Zins, Marie Descatha, Alexis Le Moual, Nicole Dumas, Orianne Occupational Exposures to Organic Solvents and Asthma Symptoms in the CONSTANCES Cohort |
title | Occupational Exposures to Organic Solvents and Asthma Symptoms in the CONSTANCES Cohort |
title_full | Occupational Exposures to Organic Solvents and Asthma Symptoms in the CONSTANCES Cohort |
title_fullStr | Occupational Exposures to Organic Solvents and Asthma Symptoms in the CONSTANCES Cohort |
title_full_unstemmed | Occupational Exposures to Organic Solvents and Asthma Symptoms in the CONSTANCES Cohort |
title_short | Occupational Exposures to Organic Solvents and Asthma Symptoms in the CONSTANCES Cohort |
title_sort | occupational exposures to organic solvents and asthma symptoms in the constances cohort |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431091/ https://www.ncbi.nlm.nih.gov/pubmed/34501848 http://dx.doi.org/10.3390/ijerph18179258 |
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