Cargando…

Occupational Exposures to Organic Solvents and Asthma Symptoms in the CONSTANCES Cohort

Solvents are used in many workplaces and may be airway irritants but few studies have examined their association with asthma. We studied this question in CONSTANCES (cohort of ‘CONSulTANts des Centres d’Examens de Santé’), a large French cohort. Current asthma and asthma symptom scores were defined...

Descripción completa

Detalles Bibliográficos
Autores principales: Sit, Guillaume, Letellier, Noémie, Iwatsubo, Yuriko, Goldberg, Marcel, Leynaert, Bénédicte, Nadif, Rachel, Ribet, Céline, Roche, Nicolas, Roquelaure, Yves, Varraso, Raphaëlle, Zins, Marie, Descatha, Alexis, Le Moual, Nicole, Dumas, Orianne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431091/
https://www.ncbi.nlm.nih.gov/pubmed/34501848
http://dx.doi.org/10.3390/ijerph18179258
_version_ 1783750855598538752
author Sit, Guillaume
Letellier, Noémie
Iwatsubo, Yuriko
Goldberg, Marcel
Leynaert, Bénédicte
Nadif, Rachel
Ribet, Céline
Roche, Nicolas
Roquelaure, Yves
Varraso, Raphaëlle
Zins, Marie
Descatha, Alexis
Le Moual, Nicole
Dumas, Orianne
author_facet Sit, Guillaume
Letellier, Noémie
Iwatsubo, Yuriko
Goldberg, Marcel
Leynaert, Bénédicte
Nadif, Rachel
Ribet, Céline
Roche, Nicolas
Roquelaure, Yves
Varraso, Raphaëlle
Zins, Marie
Descatha, Alexis
Le Moual, Nicole
Dumas, Orianne
author_sort Sit, Guillaume
collection PubMed
description Solvents are used in many workplaces and may be airway irritants but few studies have examined their association with asthma. We studied this question in CONSTANCES (cohort of ‘CONSulTANts des Centres d’Examens de Santé’), a large French cohort. Current asthma and asthma symptom scores were defined by participant-reported respiratory symptoms, asthma medication or attacks, and the sum of 5 symptoms, in the past 12 months, respectively. Lifetime exposures to 5 organic solvents, paints and inks were assessed by questionnaire and a population-based Job-Exposure Matrix (JEM). Cross-sectional associations between exposures and outcomes were evaluated by gender using logistic and negative binomial regressions adjusted for age, smoking habits and body mass index. Analyses included 115,757 adults (54% women, mean age 47 years, 9% current asthma). Self-reported exposure to ≥1 solvent was significantly associated with current asthma in men and women, whereas using the JEM, a significant association was observed only in women. Significant associations between exposures to ≥1 solvent and asthma symptom score were observed for both self-report (mean score ratio, 95%CI, women: 1.36, 1.31–1.42; men: 1.34, 1.30–1.40) and JEM (women: 1.10, 1.07–1.15; men: 1.14, 1.09–1.18). Exposure to specific solvents was significantly associated with higher asthma symptom score. Occupational exposure to solvents should be systematically sought when caring for asthma.
format Online
Article
Text
id pubmed-8431091
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-84310912021-09-11 Occupational Exposures to Organic Solvents and Asthma Symptoms in the CONSTANCES Cohort Sit, Guillaume Letellier, Noémie Iwatsubo, Yuriko Goldberg, Marcel Leynaert, Bénédicte Nadif, Rachel Ribet, Céline Roche, Nicolas Roquelaure, Yves Varraso, Raphaëlle Zins, Marie Descatha, Alexis Le Moual, Nicole Dumas, Orianne Int J Environ Res Public Health Article Solvents are used in many workplaces and may be airway irritants but few studies have examined their association with asthma. We studied this question in CONSTANCES (cohort of ‘CONSulTANts des Centres d’Examens de Santé’), a large French cohort. Current asthma and asthma symptom scores were defined by participant-reported respiratory symptoms, asthma medication or attacks, and the sum of 5 symptoms, in the past 12 months, respectively. Lifetime exposures to 5 organic solvents, paints and inks were assessed by questionnaire and a population-based Job-Exposure Matrix (JEM). Cross-sectional associations between exposures and outcomes were evaluated by gender using logistic and negative binomial regressions adjusted for age, smoking habits and body mass index. Analyses included 115,757 adults (54% women, mean age 47 years, 9% current asthma). Self-reported exposure to ≥1 solvent was significantly associated with current asthma in men and women, whereas using the JEM, a significant association was observed only in women. Significant associations between exposures to ≥1 solvent and asthma symptom score were observed for both self-report (mean score ratio, 95%CI, women: 1.36, 1.31–1.42; men: 1.34, 1.30–1.40) and JEM (women: 1.10, 1.07–1.15; men: 1.14, 1.09–1.18). Exposure to specific solvents was significantly associated with higher asthma symptom score. Occupational exposure to solvents should be systematically sought when caring for asthma. MDPI 2021-09-02 /pmc/articles/PMC8431091/ /pubmed/34501848 http://dx.doi.org/10.3390/ijerph18179258 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sit, Guillaume
Letellier, Noémie
Iwatsubo, Yuriko
Goldberg, Marcel
Leynaert, Bénédicte
Nadif, Rachel
Ribet, Céline
Roche, Nicolas
Roquelaure, Yves
Varraso, Raphaëlle
Zins, Marie
Descatha, Alexis
Le Moual, Nicole
Dumas, Orianne
Occupational Exposures to Organic Solvents and Asthma Symptoms in the CONSTANCES Cohort
title Occupational Exposures to Organic Solvents and Asthma Symptoms in the CONSTANCES Cohort
title_full Occupational Exposures to Organic Solvents and Asthma Symptoms in the CONSTANCES Cohort
title_fullStr Occupational Exposures to Organic Solvents and Asthma Symptoms in the CONSTANCES Cohort
title_full_unstemmed Occupational Exposures to Organic Solvents and Asthma Symptoms in the CONSTANCES Cohort
title_short Occupational Exposures to Organic Solvents and Asthma Symptoms in the CONSTANCES Cohort
title_sort occupational exposures to organic solvents and asthma symptoms in the constances cohort
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431091/
https://www.ncbi.nlm.nih.gov/pubmed/34501848
http://dx.doi.org/10.3390/ijerph18179258
work_keys_str_mv AT sitguillaume occupationalexposurestoorganicsolventsandasthmasymptomsintheconstancescohort
AT letelliernoemie occupationalexposurestoorganicsolventsandasthmasymptomsintheconstancescohort
AT iwatsuboyuriko occupationalexposurestoorganicsolventsandasthmasymptomsintheconstancescohort
AT goldbergmarcel occupationalexposurestoorganicsolventsandasthmasymptomsintheconstancescohort
AT leynaertbenedicte occupationalexposurestoorganicsolventsandasthmasymptomsintheconstancescohort
AT nadifrachel occupationalexposurestoorganicsolventsandasthmasymptomsintheconstancescohort
AT ribetceline occupationalexposurestoorganicsolventsandasthmasymptomsintheconstancescohort
AT rochenicolas occupationalexposurestoorganicsolventsandasthmasymptomsintheconstancescohort
AT roquelaureyves occupationalexposurestoorganicsolventsandasthmasymptomsintheconstancescohort
AT varrasoraphaelle occupationalexposurestoorganicsolventsandasthmasymptomsintheconstancescohort
AT zinsmarie occupationalexposurestoorganicsolventsandasthmasymptomsintheconstancescohort
AT descathaalexis occupationalexposurestoorganicsolventsandasthmasymptomsintheconstancescohort
AT lemoualnicole occupationalexposurestoorganicsolventsandasthmasymptomsintheconstancescohort
AT dumasorianne occupationalexposurestoorganicsolventsandasthmasymptomsintheconstancescohort