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Characteristics of Food Protein-Derived Antidiabetic Bioactive Peptides: A Literature Update

Diabetes, a glucose metabolic disorder, is considered one of the biggest challenges associated with a complex complication of health crises in the modern lifestyle. Inhibition or reduction of the dipeptidyl peptidase IV (DPP-IV), alpha-glucosidase, and protein-tyrosine phosphatase 1B (PTP-1B) enzyme...

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Detalles Bibliográficos
Autores principales: Nong, Nhung Thi Phuong, Hsu, Jue-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431147/
https://www.ncbi.nlm.nih.gov/pubmed/34502417
http://dx.doi.org/10.3390/ijms22179508
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author Nong, Nhung Thi Phuong
Hsu, Jue-Liang
author_facet Nong, Nhung Thi Phuong
Hsu, Jue-Liang
author_sort Nong, Nhung Thi Phuong
collection PubMed
description Diabetes, a glucose metabolic disorder, is considered one of the biggest challenges associated with a complex complication of health crises in the modern lifestyle. Inhibition or reduction of the dipeptidyl peptidase IV (DPP-IV), alpha-glucosidase, and protein-tyrosine phosphatase 1B (PTP-1B) enzyme activities or expressions are notably considered as the promising therapeutic strategies for the management of type 2 diabetes (T2D). Various food protein-derived antidiabetic bioactive peptides have been isolated and verified. This review provides an overview of the DPP-IV, PTP-1B, and α-glucosidase inhibitors, and updates on the methods for the discovery of DPP-IV inhibitory peptides released from food-protein hydrolysate. The finding of novel bioactive peptides involves studies about the strategy of separation fractionation, the identification of peptide sequences, and the evaluation of peptide characteristics in vitro, in silico, in situ, and in vivo. The potential of bioactive peptides suggests useful applications in the prevention and management of diabetes. Furthermore, evidence of clinical studies is necessary for the validation of these peptides’ efficiencies before commercial applications.
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spelling pubmed-84311472021-09-11 Characteristics of Food Protein-Derived Antidiabetic Bioactive Peptides: A Literature Update Nong, Nhung Thi Phuong Hsu, Jue-Liang Int J Mol Sci Review Diabetes, a glucose metabolic disorder, is considered one of the biggest challenges associated with a complex complication of health crises in the modern lifestyle. Inhibition or reduction of the dipeptidyl peptidase IV (DPP-IV), alpha-glucosidase, and protein-tyrosine phosphatase 1B (PTP-1B) enzyme activities or expressions are notably considered as the promising therapeutic strategies for the management of type 2 diabetes (T2D). Various food protein-derived antidiabetic bioactive peptides have been isolated and verified. This review provides an overview of the DPP-IV, PTP-1B, and α-glucosidase inhibitors, and updates on the methods for the discovery of DPP-IV inhibitory peptides released from food-protein hydrolysate. The finding of novel bioactive peptides involves studies about the strategy of separation fractionation, the identification of peptide sequences, and the evaluation of peptide characteristics in vitro, in silico, in situ, and in vivo. The potential of bioactive peptides suggests useful applications in the prevention and management of diabetes. Furthermore, evidence of clinical studies is necessary for the validation of these peptides’ efficiencies before commercial applications. MDPI 2021-09-01 /pmc/articles/PMC8431147/ /pubmed/34502417 http://dx.doi.org/10.3390/ijms22179508 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Nong, Nhung Thi Phuong
Hsu, Jue-Liang
Characteristics of Food Protein-Derived Antidiabetic Bioactive Peptides: A Literature Update
title Characteristics of Food Protein-Derived Antidiabetic Bioactive Peptides: A Literature Update
title_full Characteristics of Food Protein-Derived Antidiabetic Bioactive Peptides: A Literature Update
title_fullStr Characteristics of Food Protein-Derived Antidiabetic Bioactive Peptides: A Literature Update
title_full_unstemmed Characteristics of Food Protein-Derived Antidiabetic Bioactive Peptides: A Literature Update
title_short Characteristics of Food Protein-Derived Antidiabetic Bioactive Peptides: A Literature Update
title_sort characteristics of food protein-derived antidiabetic bioactive peptides: a literature update
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431147/
https://www.ncbi.nlm.nih.gov/pubmed/34502417
http://dx.doi.org/10.3390/ijms22179508
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