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Role of the Novel Peptide Phoenixin in Stress Response and Possible Interactions with Nesfatin-1

The novel peptide phoenixin was shown to be involved in several physiological processes ranging from reproduction to food intake. Interest in this protein has steadily increased over the last few years and its known implications have become much broader, playing a role in glucose homeostasis, anxiet...

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Detalles Bibliográficos
Autores principales: Friedrich, Tiemo, Stengel, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431171/
https://www.ncbi.nlm.nih.gov/pubmed/34502065
http://dx.doi.org/10.3390/ijms22179156
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author Friedrich, Tiemo
Stengel, Andreas
author_facet Friedrich, Tiemo
Stengel, Andreas
author_sort Friedrich, Tiemo
collection PubMed
description The novel peptide phoenixin was shown to be involved in several physiological processes ranging from reproduction to food intake. Interest in this protein has steadily increased over the last few years and its known implications have become much broader, playing a role in glucose homeostasis, anxiety, nociception, and pruritus. Phoenixin is expressed in a multitude of organs such as the small intestine, pancreas, and in the hypothalamus, as well as several other brain nuclei influencing numerous physiological functions. Its highly conserved amino-acid sequence amongst species leads to the assumption, that phoenixin might be involved in essential physiological functions. Its co-expression and opposing functionality to the extensively studied peptide nesfatin-1 has given rise to the idea of a possible counterbalancing role. Several recent publications focused on phoenixin’s role in stress reactions, namely restraint stress and lipopolysaccharide-induced inflammation response, in which also nesfatin-1 is known to be altered. This review provides an overview on the phoenixins and nesfatin-1 properties and putative effects, and especially highlights the recent developments on their role and interaction in the response to response.
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spelling pubmed-84311712021-09-11 Role of the Novel Peptide Phoenixin in Stress Response and Possible Interactions with Nesfatin-1 Friedrich, Tiemo Stengel, Andreas Int J Mol Sci Review The novel peptide phoenixin was shown to be involved in several physiological processes ranging from reproduction to food intake. Interest in this protein has steadily increased over the last few years and its known implications have become much broader, playing a role in glucose homeostasis, anxiety, nociception, and pruritus. Phoenixin is expressed in a multitude of organs such as the small intestine, pancreas, and in the hypothalamus, as well as several other brain nuclei influencing numerous physiological functions. Its highly conserved amino-acid sequence amongst species leads to the assumption, that phoenixin might be involved in essential physiological functions. Its co-expression and opposing functionality to the extensively studied peptide nesfatin-1 has given rise to the idea of a possible counterbalancing role. Several recent publications focused on phoenixin’s role in stress reactions, namely restraint stress and lipopolysaccharide-induced inflammation response, in which also nesfatin-1 is known to be altered. This review provides an overview on the phoenixins and nesfatin-1 properties and putative effects, and especially highlights the recent developments on their role and interaction in the response to response. MDPI 2021-08-25 /pmc/articles/PMC8431171/ /pubmed/34502065 http://dx.doi.org/10.3390/ijms22179156 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Friedrich, Tiemo
Stengel, Andreas
Role of the Novel Peptide Phoenixin in Stress Response and Possible Interactions with Nesfatin-1
title Role of the Novel Peptide Phoenixin in Stress Response and Possible Interactions with Nesfatin-1
title_full Role of the Novel Peptide Phoenixin in Stress Response and Possible Interactions with Nesfatin-1
title_fullStr Role of the Novel Peptide Phoenixin in Stress Response and Possible Interactions with Nesfatin-1
title_full_unstemmed Role of the Novel Peptide Phoenixin in Stress Response and Possible Interactions with Nesfatin-1
title_short Role of the Novel Peptide Phoenixin in Stress Response and Possible Interactions with Nesfatin-1
title_sort role of the novel peptide phoenixin in stress response and possible interactions with nesfatin-1
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431171/
https://www.ncbi.nlm.nih.gov/pubmed/34502065
http://dx.doi.org/10.3390/ijms22179156
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