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The Effect of Hyperbaric Therapy on Brown Adipose Tissue in Rats

Brown adipose tissue (BAT) plays an important role in thermogenic regulation, which contributes to alleviating diet-induced obesity through uncoupling protein 1 (UCP1) expression. While cold exposure and physical exercise are known to increase BAT development and UCP1 expression, the contribution of...

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Autores principales: Lee, Chang-Hyung, Choi, Young-A, Heo, Sung-Jin, Song, Parkyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431214/
https://www.ncbi.nlm.nih.gov/pubmed/34501754
http://dx.doi.org/10.3390/ijerph18179165
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author Lee, Chang-Hyung
Choi, Young-A
Heo, Sung-Jin
Song, Parkyong
author_facet Lee, Chang-Hyung
Choi, Young-A
Heo, Sung-Jin
Song, Parkyong
author_sort Lee, Chang-Hyung
collection PubMed
description Brown adipose tissue (BAT) plays an important role in thermogenic regulation, which contributes to alleviating diet-induced obesity through uncoupling protein 1 (UCP1) expression. While cold exposure and physical exercise are known to increase BAT development and UCP1 expression, the contribution of hyperbaric oxygen (HBO) therapy to BAT maturation remains largely unknown. Here, we show that HBO treatment sufficiently increases BAT volumes and thermogenic protein levels in Sprague-Dawley rats. Through (18)F-FDG PET/CT analysis, we found that exposure to high-pressure oxygen (1.5–2.5 ATA) for 7 consecutive days increased radiolabeled glucose uptake and BAT development to an extent comparable to cold exposure. Consistent with BAT maturation, thermogenic protein levels, such as those of UCP1 and peroxisome proliferator-activated receptor γ coactivator 1α (PGC−1α), were largely increased by HBO treatment. Taken together, we suggest HBO therapy as a novel method of inducing BAT development, considering its therapeutic potential for the treatment of metabolic disorders.
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spelling pubmed-84312142021-09-11 The Effect of Hyperbaric Therapy on Brown Adipose Tissue in Rats Lee, Chang-Hyung Choi, Young-A Heo, Sung-Jin Song, Parkyong Int J Environ Res Public Health Brief Report Brown adipose tissue (BAT) plays an important role in thermogenic regulation, which contributes to alleviating diet-induced obesity through uncoupling protein 1 (UCP1) expression. While cold exposure and physical exercise are known to increase BAT development and UCP1 expression, the contribution of hyperbaric oxygen (HBO) therapy to BAT maturation remains largely unknown. Here, we show that HBO treatment sufficiently increases BAT volumes and thermogenic protein levels in Sprague-Dawley rats. Through (18)F-FDG PET/CT analysis, we found that exposure to high-pressure oxygen (1.5–2.5 ATA) for 7 consecutive days increased radiolabeled glucose uptake and BAT development to an extent comparable to cold exposure. Consistent with BAT maturation, thermogenic protein levels, such as those of UCP1 and peroxisome proliferator-activated receptor γ coactivator 1α (PGC−1α), were largely increased by HBO treatment. Taken together, we suggest HBO therapy as a novel method of inducing BAT development, considering its therapeutic potential for the treatment of metabolic disorders. MDPI 2021-08-31 /pmc/articles/PMC8431214/ /pubmed/34501754 http://dx.doi.org/10.3390/ijerph18179165 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Lee, Chang-Hyung
Choi, Young-A
Heo, Sung-Jin
Song, Parkyong
The Effect of Hyperbaric Therapy on Brown Adipose Tissue in Rats
title The Effect of Hyperbaric Therapy on Brown Adipose Tissue in Rats
title_full The Effect of Hyperbaric Therapy on Brown Adipose Tissue in Rats
title_fullStr The Effect of Hyperbaric Therapy on Brown Adipose Tissue in Rats
title_full_unstemmed The Effect of Hyperbaric Therapy on Brown Adipose Tissue in Rats
title_short The Effect of Hyperbaric Therapy on Brown Adipose Tissue in Rats
title_sort effect of hyperbaric therapy on brown adipose tissue in rats
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431214/
https://www.ncbi.nlm.nih.gov/pubmed/34501754
http://dx.doi.org/10.3390/ijerph18179165
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