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Interferon-γ-Inducible Chemokines as Prognostic Markers for Lung Cancer

Interferon (IFN)-γ-inducible chemokines in the CXCR3/ligand axis are involved in cell-mediated immunity and play a significant role in the progression of cancer. We enrolled patients with lung cancer (n = 144) and healthy volunteers as the controls (n = 140). Initial blood samples were collected and...

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Autores principales: Lee, Keu-Sung, Chung, Wou-Young, Park, Ji-Eun, Jung, Yun-Jung, Park, Joo-Hun, Sheen, Seung-Soo, Park, Kwang-Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431216/
https://www.ncbi.nlm.nih.gov/pubmed/34501934
http://dx.doi.org/10.3390/ijerph18179345
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author Lee, Keu-Sung
Chung, Wou-Young
Park, Ji-Eun
Jung, Yun-Jung
Park, Joo-Hun
Sheen, Seung-Soo
Park, Kwang-Joo
author_facet Lee, Keu-Sung
Chung, Wou-Young
Park, Ji-Eun
Jung, Yun-Jung
Park, Joo-Hun
Sheen, Seung-Soo
Park, Kwang-Joo
author_sort Lee, Keu-Sung
collection PubMed
description Interferon (IFN)-γ-inducible chemokines in the CXCR3/ligand axis are involved in cell-mediated immunity and play a significant role in the progression of cancer. We enrolled patients with lung cancer (n = 144) and healthy volunteers as the controls (n = 140). Initial blood samples were collected and concentrations of IFN-γ and IFN-γ-inducible chemokines CXCL9, CXCL10, and CXCL11 were measured using enzyme-linked immunosorbent assay. Of patients with lung cancer, 125 had non-small cell lung cancer (NSCLC) and 19 had small cell lung cancer. The area under the curve (AUC) (95% CI) of CXCL9 was 0.83 (0.80–0.89) for differentiating lung cancer patients from controls. The levels of all the markers were significantly higher in NSCLC patients with stage IV than in those with stages I–III. A Kaplan-Meier survival analysis showed that NSCLC cancer patients with higher levels of all markers showed poorer survival than those with lower levels. In Cox multivariate analysis of patients with NSCLC, independent prognostic factors for overall survival were CXCL9 and CXCL11. CXCL9 was the only independent prognostic factor for cancer-specific survival. Serum IFN-γ-inducible chemokines may be useful as clinical markers of metastasis and prognosis in NSCLC, and CXCL9 levels showed the most significant results.
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spelling pubmed-84312162021-09-11 Interferon-γ-Inducible Chemokines as Prognostic Markers for Lung Cancer Lee, Keu-Sung Chung, Wou-Young Park, Ji-Eun Jung, Yun-Jung Park, Joo-Hun Sheen, Seung-Soo Park, Kwang-Joo Int J Environ Res Public Health Article Interferon (IFN)-γ-inducible chemokines in the CXCR3/ligand axis are involved in cell-mediated immunity and play a significant role in the progression of cancer. We enrolled patients with lung cancer (n = 144) and healthy volunteers as the controls (n = 140). Initial blood samples were collected and concentrations of IFN-γ and IFN-γ-inducible chemokines CXCL9, CXCL10, and CXCL11 were measured using enzyme-linked immunosorbent assay. Of patients with lung cancer, 125 had non-small cell lung cancer (NSCLC) and 19 had small cell lung cancer. The area under the curve (AUC) (95% CI) of CXCL9 was 0.83 (0.80–0.89) for differentiating lung cancer patients from controls. The levels of all the markers were significantly higher in NSCLC patients with stage IV than in those with stages I–III. A Kaplan-Meier survival analysis showed that NSCLC cancer patients with higher levels of all markers showed poorer survival than those with lower levels. In Cox multivariate analysis of patients with NSCLC, independent prognostic factors for overall survival were CXCL9 and CXCL11. CXCL9 was the only independent prognostic factor for cancer-specific survival. Serum IFN-γ-inducible chemokines may be useful as clinical markers of metastasis and prognosis in NSCLC, and CXCL9 levels showed the most significant results. MDPI 2021-09-04 /pmc/articles/PMC8431216/ /pubmed/34501934 http://dx.doi.org/10.3390/ijerph18179345 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, Keu-Sung
Chung, Wou-Young
Park, Ji-Eun
Jung, Yun-Jung
Park, Joo-Hun
Sheen, Seung-Soo
Park, Kwang-Joo
Interferon-γ-Inducible Chemokines as Prognostic Markers for Lung Cancer
title Interferon-γ-Inducible Chemokines as Prognostic Markers for Lung Cancer
title_full Interferon-γ-Inducible Chemokines as Prognostic Markers for Lung Cancer
title_fullStr Interferon-γ-Inducible Chemokines as Prognostic Markers for Lung Cancer
title_full_unstemmed Interferon-γ-Inducible Chemokines as Prognostic Markers for Lung Cancer
title_short Interferon-γ-Inducible Chemokines as Prognostic Markers for Lung Cancer
title_sort interferon-γ-inducible chemokines as prognostic markers for lung cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431216/
https://www.ncbi.nlm.nih.gov/pubmed/34501934
http://dx.doi.org/10.3390/ijerph18179345
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