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Effective Oncoleaking Treatment of Pancreatic Cancer by Claudin-Targeted Suicide Gene Therapy with Clostridium perfringens Enterotoxin (CPE)

SIMPLE SUMMARY: Current therapies for pancreas carcinoma (PC) are of limited efficacy due to tumor aggressiveness and therapy resistance. Bacterial toxins with pore-forming (oncoleaking) potential are promising tools in cancer therapy. We have developed a novel, suicide gene therapy treatment, based...

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Detalles Bibliográficos
Autores principales:	Pahle, Jessica, Kobelt, Dennis, Aumann, Jutta, Behrens, Diana, Daberkow, Ole, Mokritzkij, Margarita, Piontek, Jörg, Stein, Ulrike, Walther, Wolfgang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431234/ https://www.ncbi.nlm.nih.gov/pubmed/34503203 http://dx.doi.org/10.3390/cancers13174393

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