Cargando…

Kv1.3 Controls Mitochondrial Dynamics during Cell Cycle Progression

SIMPLE SUMMARY: Voltage-dependent potassium channels control the proliferation of mammalian cells. In addition, mitochondria physiology is highly dynamic during the cell cycle. The aim of this work was to investigate whether the Kv1.3 channel participates in the mitochondrial control of cell cycle p...

Descripción completa

Detalles Bibliográficos
Autores principales: Capera, Jesusa, Pérez-Verdaguer, Mireia, Navarro-Pérez, María, Felipe, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431373/
https://www.ncbi.nlm.nih.gov/pubmed/34503267
http://dx.doi.org/10.3390/cancers13174457
_version_ 1783750921573892096
author Capera, Jesusa
Pérez-Verdaguer, Mireia
Navarro-Pérez, María
Felipe, Antonio
author_facet Capera, Jesusa
Pérez-Verdaguer, Mireia
Navarro-Pérez, María
Felipe, Antonio
author_sort Capera, Jesusa
collection PubMed
description SIMPLE SUMMARY: Voltage-dependent potassium channels control the proliferation of mammalian cells. In addition, mitochondria physiology is highly dynamic during the cell cycle. The aim of this work was to investigate whether the Kv1.3 channel participates in the mitochondrial control of cell cycle progression. Our data confirmed that Kv1.3 facilitates the proliferation of preadipocytes through the control of mitochondrial dynamics. In addition, adipogenesis was also dependent on Kv1.3 expression. We shed light on the role of Kv1.3 in mitochondria and adipose tissue metabolism, contributing further to the control of cell proliferation by Kv1.3. ABSTRACT: The voltage-gated potassium channel Kv1.3 is a potential therapeutic target for obesity and diabetes. The genetic ablation and pharmacological inhibition of Kv1.3 lead to a lean phenotype in rodents. The mechanism of regulation of body weight and energy homeostasis involves Kv1.3 expression in different organs, including white and brown adipose tissues. Here, we show that Kv1.3 promotes the proliferation of preadipocytes through the control of mitochondrial dynamics. Kv1.3 is expressed in mitochondria exhibiting high affinity for the perinuclear population. The mitochondrial network is highly dynamic during the cell cycle, showing continuous fusion-fission events. The formation of a hyperfused mitochondrial network at the G1/S phase of the cell cycle is dependent on Kv1.3 expression. Our results demonstrate that Kv1.3 promotes preadipocyte proliferation and differentiation by controlling mitochondrial membrane potential and mitochondrial dynamics at the G1 phase of the cell cycle.
format Online
Article
Text
id pubmed-8431373
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-84313732021-09-11 Kv1.3 Controls Mitochondrial Dynamics during Cell Cycle Progression Capera, Jesusa Pérez-Verdaguer, Mireia Navarro-Pérez, María Felipe, Antonio Cancers (Basel) Article SIMPLE SUMMARY: Voltage-dependent potassium channels control the proliferation of mammalian cells. In addition, mitochondria physiology is highly dynamic during the cell cycle. The aim of this work was to investigate whether the Kv1.3 channel participates in the mitochondrial control of cell cycle progression. Our data confirmed that Kv1.3 facilitates the proliferation of preadipocytes through the control of mitochondrial dynamics. In addition, adipogenesis was also dependent on Kv1.3 expression. We shed light on the role of Kv1.3 in mitochondria and adipose tissue metabolism, contributing further to the control of cell proliferation by Kv1.3. ABSTRACT: The voltage-gated potassium channel Kv1.3 is a potential therapeutic target for obesity and diabetes. The genetic ablation and pharmacological inhibition of Kv1.3 lead to a lean phenotype in rodents. The mechanism of regulation of body weight and energy homeostasis involves Kv1.3 expression in different organs, including white and brown adipose tissues. Here, we show that Kv1.3 promotes the proliferation of preadipocytes through the control of mitochondrial dynamics. Kv1.3 is expressed in mitochondria exhibiting high affinity for the perinuclear population. The mitochondrial network is highly dynamic during the cell cycle, showing continuous fusion-fission events. The formation of a hyperfused mitochondrial network at the G1/S phase of the cell cycle is dependent on Kv1.3 expression. Our results demonstrate that Kv1.3 promotes preadipocyte proliferation and differentiation by controlling mitochondrial membrane potential and mitochondrial dynamics at the G1 phase of the cell cycle. MDPI 2021-09-04 /pmc/articles/PMC8431373/ /pubmed/34503267 http://dx.doi.org/10.3390/cancers13174457 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Capera, Jesusa
Pérez-Verdaguer, Mireia
Navarro-Pérez, María
Felipe, Antonio
Kv1.3 Controls Mitochondrial Dynamics during Cell Cycle Progression
title Kv1.3 Controls Mitochondrial Dynamics during Cell Cycle Progression
title_full Kv1.3 Controls Mitochondrial Dynamics during Cell Cycle Progression
title_fullStr Kv1.3 Controls Mitochondrial Dynamics during Cell Cycle Progression
title_full_unstemmed Kv1.3 Controls Mitochondrial Dynamics during Cell Cycle Progression
title_short Kv1.3 Controls Mitochondrial Dynamics during Cell Cycle Progression
title_sort kv1.3 controls mitochondrial dynamics during cell cycle progression
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431373/
https://www.ncbi.nlm.nih.gov/pubmed/34503267
http://dx.doi.org/10.3390/cancers13174457
work_keys_str_mv AT caperajesusa kv13controlsmitochondrialdynamicsduringcellcycleprogression
AT perezverdaguermireia kv13controlsmitochondrialdynamicsduringcellcycleprogression
AT navarroperezmaria kv13controlsmitochondrialdynamicsduringcellcycleprogression
AT felipeantonio kv13controlsmitochondrialdynamicsduringcellcycleprogression