Cargando…
Oral Microbiota Features in Subjects with Down Syndrome and Periodontal Diseases: A Systematic Review
Down syndrome (DS) is a genetic disorder associated with early-onset periodontitis and other periodontal diseases (PDs). The present work aimed to systematically review the scientific literature reporting studies in vivo on oral microbiota features in subjects with DS and related periodontal health...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431440/ https://www.ncbi.nlm.nih.gov/pubmed/34502159 http://dx.doi.org/10.3390/ijms22179251 |
_version_ | 1783750937208160256 |
---|---|
author | Contaldo, Maria Lucchese, Alberta Romano, Antonio Della Vella, Fedora Di Stasio, Dario Serpico, Rosario Petruzzi, Massimo |
author_facet | Contaldo, Maria Lucchese, Alberta Romano, Antonio Della Vella, Fedora Di Stasio, Dario Serpico, Rosario Petruzzi, Massimo |
author_sort | Contaldo, Maria |
collection | PubMed |
description | Down syndrome (DS) is a genetic disorder associated with early-onset periodontitis and other periodontal diseases (PDs). The present work aimed to systematically review the scientific literature reporting studies in vivo on oral microbiota features in subjects with DS and related periodontal health and to highlight any correlation and difference with subjects not affected by DS, with and without PDs. PubMed, Web of Science, Scopus and Cochrane were searched for relevant studies in May 2021. The participants were subjects affected by Down syndrome (DS) with and without periodontal diseases; the study compared subjects with periodontal diseases but not affected by DS, and DS without periodontal diseases; the outcomes were the differences in oral microbiota/periodontopathogen bacterial composition among subjects considered; the study design was a systematic review. Study quality was assessed with risk of bias in non-randomized studies of interventions (ROBINS-I). Of the 954 references retrieved, 26 studies were considered. The conclusions from the qualitative assessment of the papers revealed an increasing knowledge over the last years of the microbiota associated with DS and their periodontal diseases, in comparison with healthy subjects and subjects with other kinds of mental disabilities. Few data have emerged on the mycobiome and virobiome of DS, hence, further investigations are still necessary. |
format | Online Article Text |
id | pubmed-8431440 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84314402021-09-11 Oral Microbiota Features in Subjects with Down Syndrome and Periodontal Diseases: A Systematic Review Contaldo, Maria Lucchese, Alberta Romano, Antonio Della Vella, Fedora Di Stasio, Dario Serpico, Rosario Petruzzi, Massimo Int J Mol Sci Review Down syndrome (DS) is a genetic disorder associated with early-onset periodontitis and other periodontal diseases (PDs). The present work aimed to systematically review the scientific literature reporting studies in vivo on oral microbiota features in subjects with DS and related periodontal health and to highlight any correlation and difference with subjects not affected by DS, with and without PDs. PubMed, Web of Science, Scopus and Cochrane were searched for relevant studies in May 2021. The participants were subjects affected by Down syndrome (DS) with and without periodontal diseases; the study compared subjects with periodontal diseases but not affected by DS, and DS without periodontal diseases; the outcomes were the differences in oral microbiota/periodontopathogen bacterial composition among subjects considered; the study design was a systematic review. Study quality was assessed with risk of bias in non-randomized studies of interventions (ROBINS-I). Of the 954 references retrieved, 26 studies were considered. The conclusions from the qualitative assessment of the papers revealed an increasing knowledge over the last years of the microbiota associated with DS and their periodontal diseases, in comparison with healthy subjects and subjects with other kinds of mental disabilities. Few data have emerged on the mycobiome and virobiome of DS, hence, further investigations are still necessary. MDPI 2021-08-26 /pmc/articles/PMC8431440/ /pubmed/34502159 http://dx.doi.org/10.3390/ijms22179251 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Contaldo, Maria Lucchese, Alberta Romano, Antonio Della Vella, Fedora Di Stasio, Dario Serpico, Rosario Petruzzi, Massimo Oral Microbiota Features in Subjects with Down Syndrome and Periodontal Diseases: A Systematic Review |
title | Oral Microbiota Features in Subjects with Down Syndrome and Periodontal Diseases: A Systematic Review |
title_full | Oral Microbiota Features in Subjects with Down Syndrome and Periodontal Diseases: A Systematic Review |
title_fullStr | Oral Microbiota Features in Subjects with Down Syndrome and Periodontal Diseases: A Systematic Review |
title_full_unstemmed | Oral Microbiota Features in Subjects with Down Syndrome and Periodontal Diseases: A Systematic Review |
title_short | Oral Microbiota Features in Subjects with Down Syndrome and Periodontal Diseases: A Systematic Review |
title_sort | oral microbiota features in subjects with down syndrome and periodontal diseases: a systematic review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431440/ https://www.ncbi.nlm.nih.gov/pubmed/34502159 http://dx.doi.org/10.3390/ijms22179251 |
work_keys_str_mv | AT contaldomaria oralmicrobiotafeaturesinsubjectswithdownsyndromeandperiodontaldiseasesasystematicreview AT lucchesealberta oralmicrobiotafeaturesinsubjectswithdownsyndromeandperiodontaldiseasesasystematicreview AT romanoantonio oralmicrobiotafeaturesinsubjectswithdownsyndromeandperiodontaldiseasesasystematicreview AT dellavellafedora oralmicrobiotafeaturesinsubjectswithdownsyndromeandperiodontaldiseasesasystematicreview AT distasiodario oralmicrobiotafeaturesinsubjectswithdownsyndromeandperiodontaldiseasesasystematicreview AT serpicorosario oralmicrobiotafeaturesinsubjectswithdownsyndromeandperiodontaldiseasesasystematicreview AT petruzzimassimo oralmicrobiotafeaturesinsubjectswithdownsyndromeandperiodontaldiseasesasystematicreview |