Cargando…
Possible Link between Higher Transmissibility of Alpha, Kappa and Delta Variants of SARS-CoV-2 and Increased Structural Stability of Its Spike Protein and hACE2 Affinity
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) outbreak in December 2019 has caused a global pandemic. The rapid mutation rate in the virus has created alarming situations worldwide and is being attributed to the false negativity in RT-PCR tests. It has also increased the chances o...
Autores principales: | Kumar, Vipul, Singh, Jasdeep, Hasnain, Seyed E., Sundar, Durai |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431609/ https://www.ncbi.nlm.nih.gov/pubmed/34502041 http://dx.doi.org/10.3390/ijms22179131 |
Ejemplares similares
-
The alpha/B.1.1.7 SARS-CoV-2 variant exhibits significantly higher affinity for ACE-2 and requires lower inoculation doses to cause disease in K18-hACE2 mice
por: Bayarri-Olmos, Rafael, et al.
Publicado: (2021) -
Missense mutations in spike protein of SARS‐CoV‐2 delta variant contribute to the alteration in viral structure and interaction with hACE2 receptor
por: Mahmood, Tousif Bin, et al.
Publicado: (2022) -
Prediction of infectivity of SARS-CoV-2 virus based on Spike-hACE-2 interaction
por: Chaudhuri, Dwaipayan, et al.
Publicado: (2022) -
Altered hACE2 binding affinity and S1/S2 cleavage efficiency of SARS-CoV-2 spike protein mutants affect viral cell entry
por: Wang, Ke, et al.
Publicado: (2023) -
Comparative genomics, evolutionary epidemiology, and RBD-hACE2 receptor binding pattern in B.1.1.7 (Alpha) and B.1.617.2 (Delta) related to their pandemic response in UK and India
por: Chakraborty, Chiranjib, et al.
Publicado: (2022)