Epigenetic Clocks Are Not Accelerated in COVID-19 Patients

Age is a major risk factor for severe outcome of the 2019 coronavirus disease (COVID-19). In this study, we followed the hypothesis that particularly patients with accelerated epigenetic age are affected by severe outcomes of COVID-19. We investigated various DNA methylation datasets of blood sample...

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Detalles Bibliográficos
Autores principales: Franzen, Julia, Nüchtern, Selina, Tharmapalan, Vithurithra, Vieri, Margherita, Nikolić, Miloš, Han, Yang, Balfanz, Paul, Marx, Nikolaus, Dreher, Michael, Brümmendorf, Tim H., Dahl, Edgar, Beier, Fabian, Wagner, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431654/
https://www.ncbi.nlm.nih.gov/pubmed/34502212
http://dx.doi.org/10.3390/ijms22179306
Descripción
Sumario:Age is a major risk factor for severe outcome of the 2019 coronavirus disease (COVID-19). In this study, we followed the hypothesis that particularly patients with accelerated epigenetic age are affected by severe outcomes of COVID-19. We investigated various DNA methylation datasets of blood samples with epigenetic aging signatures and performed targeted bisulfite amplicon sequencing. Overall, epigenetic clocks closely correlated with the chronological age of patients, either with or without acute respiratory distress syndrome. Furthermore, lymphocytes did not reveal significantly accelerated telomere attrition. Thus, these biomarkers cannot reliably predict higher risk for severe COVID-19 infection in elderly patients.

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