Epigenetic Clocks Are Not Accelerated in COVID-19 Patients

Age is a major risk factor for severe outcome of the 2019 coronavirus disease (COVID-19). In this study, we followed the hypothesis that particularly patients with accelerated epigenetic age are affected by severe outcomes of COVID-19. We investigated various DNA methylation datasets of blood sample...

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Autores principales: Franzen, Julia, Nüchtern, Selina, Tharmapalan, Vithurithra, Vieri, Margherita, Nikolić, Miloš, Han, Yang, Balfanz, Paul, Marx, Nikolaus, Dreher, Michael, Brümmendorf, Tim H., Dahl, Edgar, Beier, Fabian, Wagner, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431654/
https://www.ncbi.nlm.nih.gov/pubmed/34502212
http://dx.doi.org/10.3390/ijms22179306
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author Franzen, Julia
Nüchtern, Selina
Tharmapalan, Vithurithra
Vieri, Margherita
Nikolić, Miloš
Han, Yang
Balfanz, Paul
Marx, Nikolaus
Dreher, Michael
Brümmendorf, Tim H.
Dahl, Edgar
Beier, Fabian
Wagner, Wolfgang
author_facet Franzen, Julia
Nüchtern, Selina
Tharmapalan, Vithurithra
Vieri, Margherita
Nikolić, Miloš
Han, Yang
Balfanz, Paul
Marx, Nikolaus
Dreher, Michael
Brümmendorf, Tim H.
Dahl, Edgar
Beier, Fabian
Wagner, Wolfgang
author_sort Franzen, Julia
collection PubMed
description Age is a major risk factor for severe outcome of the 2019 coronavirus disease (COVID-19). In this study, we followed the hypothesis that particularly patients with accelerated epigenetic age are affected by severe outcomes of COVID-19. We investigated various DNA methylation datasets of blood samples with epigenetic aging signatures and performed targeted bisulfite amplicon sequencing. Overall, epigenetic clocks closely correlated with the chronological age of patients, either with or without acute respiratory distress syndrome. Furthermore, lymphocytes did not reveal significantly accelerated telomere attrition. Thus, these biomarkers cannot reliably predict higher risk for severe COVID-19 infection in elderly patients.
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spelling pubmed-84316542021-09-11 Epigenetic Clocks Are Not Accelerated in COVID-19 Patients Franzen, Julia Nüchtern, Selina Tharmapalan, Vithurithra Vieri, Margherita Nikolić, Miloš Han, Yang Balfanz, Paul Marx, Nikolaus Dreher, Michael Brümmendorf, Tim H. Dahl, Edgar Beier, Fabian Wagner, Wolfgang Int J Mol Sci Communication Age is a major risk factor for severe outcome of the 2019 coronavirus disease (COVID-19). In this study, we followed the hypothesis that particularly patients with accelerated epigenetic age are affected by severe outcomes of COVID-19. We investigated various DNA methylation datasets of blood samples with epigenetic aging signatures and performed targeted bisulfite amplicon sequencing. Overall, epigenetic clocks closely correlated with the chronological age of patients, either with or without acute respiratory distress syndrome. Furthermore, lymphocytes did not reveal significantly accelerated telomere attrition. Thus, these biomarkers cannot reliably predict higher risk for severe COVID-19 infection in elderly patients. MDPI 2021-08-27 /pmc/articles/PMC8431654/ /pubmed/34502212 http://dx.doi.org/10.3390/ijms22179306 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Franzen, Julia
Nüchtern, Selina
Tharmapalan, Vithurithra
Vieri, Margherita
Nikolić, Miloš
Han, Yang
Balfanz, Paul
Marx, Nikolaus
Dreher, Michael
Brümmendorf, Tim H.
Dahl, Edgar
Beier, Fabian
Wagner, Wolfgang
Epigenetic Clocks Are Not Accelerated in COVID-19 Patients
title Epigenetic Clocks Are Not Accelerated in COVID-19 Patients
title_full Epigenetic Clocks Are Not Accelerated in COVID-19 Patients
title_fullStr Epigenetic Clocks Are Not Accelerated in COVID-19 Patients
title_full_unstemmed Epigenetic Clocks Are Not Accelerated in COVID-19 Patients
title_short Epigenetic Clocks Are Not Accelerated in COVID-19 Patients
title_sort epigenetic clocks are not accelerated in covid-19 patients
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431654/
https://www.ncbi.nlm.nih.gov/pubmed/34502212
http://dx.doi.org/10.3390/ijms22179306
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