Cargando…
NKT and NKT-like Cells in Autoimmune Neuroinflammatory Diseases—Multiple Sclerosis, Myasthenia Gravis and Guillain-Barre Syndrome
NKT cells comprise three subsets—type I (invariant, iNKT), type II, and NKT-like cells, of which iNKT cells are the most studied subset. They are capable of rapid cytokine production after the initial stimulus, thus they may be important for polarisation of Th cells. Due to this, they may be an impo...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431671/ https://www.ncbi.nlm.nih.gov/pubmed/34502425 http://dx.doi.org/10.3390/ijms22179520 |
_version_ | 1783750992364306432 |
---|---|
author | Zarobkiewicz, Michał K. Morawska, Izabela Michalski, Adam Roliński, Jacek Bojarska-Junak, Agnieszka |
author_facet | Zarobkiewicz, Michał K. Morawska, Izabela Michalski, Adam Roliński, Jacek Bojarska-Junak, Agnieszka |
author_sort | Zarobkiewicz, Michał K. |
collection | PubMed |
description | NKT cells comprise three subsets—type I (invariant, iNKT), type II, and NKT-like cells, of which iNKT cells are the most studied subset. They are capable of rapid cytokine production after the initial stimulus, thus they may be important for polarisation of Th cells. Due to this, they may be an important cell subset in autoimmune diseases. In the current review, we are summarising results of NKT-oriented studies in major neurological autoimmune diseases—multiple sclerosis, myasthenia gravis, and Guillain-Barre syndrome and their corresponding animal models. |
format | Online Article Text |
id | pubmed-8431671 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84316712021-09-11 NKT and NKT-like Cells in Autoimmune Neuroinflammatory Diseases—Multiple Sclerosis, Myasthenia Gravis and Guillain-Barre Syndrome Zarobkiewicz, Michał K. Morawska, Izabela Michalski, Adam Roliński, Jacek Bojarska-Junak, Agnieszka Int J Mol Sci Review NKT cells comprise three subsets—type I (invariant, iNKT), type II, and NKT-like cells, of which iNKT cells are the most studied subset. They are capable of rapid cytokine production after the initial stimulus, thus they may be important for polarisation of Th cells. Due to this, they may be an important cell subset in autoimmune diseases. In the current review, we are summarising results of NKT-oriented studies in major neurological autoimmune diseases—multiple sclerosis, myasthenia gravis, and Guillain-Barre syndrome and their corresponding animal models. MDPI 2021-09-01 /pmc/articles/PMC8431671/ /pubmed/34502425 http://dx.doi.org/10.3390/ijms22179520 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zarobkiewicz, Michał K. Morawska, Izabela Michalski, Adam Roliński, Jacek Bojarska-Junak, Agnieszka NKT and NKT-like Cells in Autoimmune Neuroinflammatory Diseases—Multiple Sclerosis, Myasthenia Gravis and Guillain-Barre Syndrome |
title | NKT and NKT-like Cells in Autoimmune Neuroinflammatory Diseases—Multiple Sclerosis, Myasthenia Gravis and Guillain-Barre Syndrome |
title_full | NKT and NKT-like Cells in Autoimmune Neuroinflammatory Diseases—Multiple Sclerosis, Myasthenia Gravis and Guillain-Barre Syndrome |
title_fullStr | NKT and NKT-like Cells in Autoimmune Neuroinflammatory Diseases—Multiple Sclerosis, Myasthenia Gravis and Guillain-Barre Syndrome |
title_full_unstemmed | NKT and NKT-like Cells in Autoimmune Neuroinflammatory Diseases—Multiple Sclerosis, Myasthenia Gravis and Guillain-Barre Syndrome |
title_short | NKT and NKT-like Cells in Autoimmune Neuroinflammatory Diseases—Multiple Sclerosis, Myasthenia Gravis and Guillain-Barre Syndrome |
title_sort | nkt and nkt-like cells in autoimmune neuroinflammatory diseases—multiple sclerosis, myasthenia gravis and guillain-barre syndrome |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431671/ https://www.ncbi.nlm.nih.gov/pubmed/34502425 http://dx.doi.org/10.3390/ijms22179520 |
work_keys_str_mv | AT zarobkiewiczmichałk nktandnktlikecellsinautoimmuneneuroinflammatorydiseasesmultiplesclerosismyastheniagravisandguillainbarresyndrome AT morawskaizabela nktandnktlikecellsinautoimmuneneuroinflammatorydiseasesmultiplesclerosismyastheniagravisandguillainbarresyndrome AT michalskiadam nktandnktlikecellsinautoimmuneneuroinflammatorydiseasesmultiplesclerosismyastheniagravisandguillainbarresyndrome AT rolinskijacek nktandnktlikecellsinautoimmuneneuroinflammatorydiseasesmultiplesclerosismyastheniagravisandguillainbarresyndrome AT bojarskajunakagnieszka nktandnktlikecellsinautoimmuneneuroinflammatorydiseasesmultiplesclerosismyastheniagravisandguillainbarresyndrome |