NKT and NKT-like Cells in Autoimmune Neuroinflammatory Diseases—Multiple Sclerosis, Myasthenia Gravis and Guillain-Barre Syndrome

NKT cells comprise three subsets—type I (invariant, iNKT), type II, and NKT-like cells, of which iNKT cells are the most studied subset. They are capable of rapid cytokine production after the initial stimulus, thus they may be important for polarisation of Th cells. Due to this, they may be an impo...

Descripción completa

Detalles Bibliográficos
Autores principales: Zarobkiewicz, Michał K., Morawska, Izabela, Michalski, Adam, Roliński, Jacek, Bojarska-Junak, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431671/
https://www.ncbi.nlm.nih.gov/pubmed/34502425
http://dx.doi.org/10.3390/ijms22179520
_version_ 1783750992364306432
author Zarobkiewicz, Michał K.
Morawska, Izabela
Michalski, Adam
Roliński, Jacek
Bojarska-Junak, Agnieszka
author_facet Zarobkiewicz, Michał K.
Morawska, Izabela
Michalski, Adam
Roliński, Jacek
Bojarska-Junak, Agnieszka
author_sort Zarobkiewicz, Michał K.
collection PubMed
description NKT cells comprise three subsets—type I (invariant, iNKT), type II, and NKT-like cells, of which iNKT cells are the most studied subset. They are capable of rapid cytokine production after the initial stimulus, thus they may be important for polarisation of Th cells. Due to this, they may be an important cell subset in autoimmune diseases. In the current review, we are summarising results of NKT-oriented studies in major neurological autoimmune diseases—multiple sclerosis, myasthenia gravis, and Guillain-Barre syndrome and their corresponding animal models.
format Online
Article
Text
id pubmed-8431671
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-84316712021-09-11 NKT and NKT-like Cells in Autoimmune Neuroinflammatory Diseases—Multiple Sclerosis, Myasthenia Gravis and Guillain-Barre Syndrome Zarobkiewicz, Michał K. Morawska, Izabela Michalski, Adam Roliński, Jacek Bojarska-Junak, Agnieszka Int J Mol Sci Review NKT cells comprise three subsets—type I (invariant, iNKT), type II, and NKT-like cells, of which iNKT cells are the most studied subset. They are capable of rapid cytokine production after the initial stimulus, thus they may be important for polarisation of Th cells. Due to this, they may be an important cell subset in autoimmune diseases. In the current review, we are summarising results of NKT-oriented studies in major neurological autoimmune diseases—multiple sclerosis, myasthenia gravis, and Guillain-Barre syndrome and their corresponding animal models. MDPI 2021-09-01 /pmc/articles/PMC8431671/ /pubmed/34502425 http://dx.doi.org/10.3390/ijms22179520 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zarobkiewicz, Michał K.
Morawska, Izabela
Michalski, Adam
Roliński, Jacek
Bojarska-Junak, Agnieszka
NKT and NKT-like Cells in Autoimmune Neuroinflammatory Diseases—Multiple Sclerosis, Myasthenia Gravis and Guillain-Barre Syndrome
title NKT and NKT-like Cells in Autoimmune Neuroinflammatory Diseases—Multiple Sclerosis, Myasthenia Gravis and Guillain-Barre Syndrome
title_full NKT and NKT-like Cells in Autoimmune Neuroinflammatory Diseases—Multiple Sclerosis, Myasthenia Gravis and Guillain-Barre Syndrome
title_fullStr NKT and NKT-like Cells in Autoimmune Neuroinflammatory Diseases—Multiple Sclerosis, Myasthenia Gravis and Guillain-Barre Syndrome
title_full_unstemmed NKT and NKT-like Cells in Autoimmune Neuroinflammatory Diseases—Multiple Sclerosis, Myasthenia Gravis and Guillain-Barre Syndrome
title_short NKT and NKT-like Cells in Autoimmune Neuroinflammatory Diseases—Multiple Sclerosis, Myasthenia Gravis and Guillain-Barre Syndrome
title_sort nkt and nkt-like cells in autoimmune neuroinflammatory diseases—multiple sclerosis, myasthenia gravis and guillain-barre syndrome
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431671/
https://www.ncbi.nlm.nih.gov/pubmed/34502425
http://dx.doi.org/10.3390/ijms22179520
work_keys_str_mv AT zarobkiewiczmichałk nktandnktlikecellsinautoimmuneneuroinflammatorydiseasesmultiplesclerosismyastheniagravisandguillainbarresyndrome
AT morawskaizabela nktandnktlikecellsinautoimmuneneuroinflammatorydiseasesmultiplesclerosismyastheniagravisandguillainbarresyndrome
AT michalskiadam nktandnktlikecellsinautoimmuneneuroinflammatorydiseasesmultiplesclerosismyastheniagravisandguillainbarresyndrome
AT rolinskijacek nktandnktlikecellsinautoimmuneneuroinflammatorydiseasesmultiplesclerosismyastheniagravisandguillainbarresyndrome
AT bojarskajunakagnieszka nktandnktlikecellsinautoimmuneneuroinflammatorydiseasesmultiplesclerosismyastheniagravisandguillainbarresyndrome

Ejemplares similares