Cargando…

The Role of the α Cell in the Pathogenesis of Diabetes: A World beyond the Mirror

Type 2 Diabetes Mellitus (T2DM) is one of the most prevalent chronic metabolic disorders, and insulin has been placed at the epicentre of its pathophysiological basis. However, the involvement of impaired alpha (α) cell function has been recognized as playing an essential role in several diseases, s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Martínez, María Sofía, Manzano, Alexander, Olivar, Luis Carlos, Nava, Manuel, Salazar, Juan, D’Marco, Luis, Ortiz, Rina, Chacín, Maricarmen, Guerrero-Wyss, Marion, Cabrera de Bravo, Mayela, Cano, Clímaco, Bermúdez, Valmore, Angarita, Lisse
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431704/ https://www.ncbi.nlm.nih.gov/pubmed/34502413 http://dx.doi.org/10.3390/ijms22179504

Ejemplares similares

Advanced Glycation End Products: New Clinical and Molecular Perspectives
por: Salazar, Juan, et al.
Publicado: (2021)

The Role of Specialized Pro-Resolving Lipid Mediators in Inflammation-Induced Carcinogenesis
por: Torres, Wheeler, et al.
Publicado: (2023)

Lipid Accumulation Product Is More Related to Insulin Resistance than the Visceral Adiposity Index in the Maracaibo City Population, Venezuela
por: Bermúdez, Valmore, et al.
Publicado: (2021)

The Sick Adipose Tissue: New Insights Into Defective Signaling and Crosstalk With the Myocardium
por: Bermúdez, Valmore, et al.
Publicado: (2021)

Microbiota and Diabetes Mellitus: Role of Lipid Mediators
por: Salazar, Juan, et al.
Publicado: (2020)

Sensitivity and Specificity Improvement in Abdominal Obesity Diagnosis Using Cluster Analysis during Waist Circumference Cut-Off Point Selection
por: Bermúdez, Valmore, et al.
Publicado: (2015)

Metabolic Syndrome and Subclinical Hypothyroidism: A Type 2 Diabetes-Dependent Association
por: Bermúdez, Valmore, et al.
Publicado: (2018)

Role of Endocrine-Disrupting Chemicals in the Pathogenesis of Non-Alcoholic Fatty Liver Disease: A Comprehensive Review
por: Cano, Raquel, et al.
Publicado: (2021)

Metabolic Syndrome: Is It Time to Add the Central Nervous System?
por: Rojas, Milagros, et al.
Publicado: (2021)

Low Doses of Melatonin to Improve Sleep in Children with ADHD: An Open-Label Trial
por: Checa-Ros, Ana, et al.
Publicado: (2023)

Neprilysin: A Potential Therapeutic Target of Arterial Hypertension?
por: Salazar, Juan, et al.
Publicado: (2020)

Specialized Proresolving Lipid Mediators: A Potential Therapeutic Target for Atherosclerosis
por: Salazar, Juan, et al.
Publicado: (2022)

Variations of Lipoprotein(a) Levels in the Metabolic Syndrome: A Report from the Maracaibo City Metabolic Syndrome Prevalence Study
por: Bermúdez, Valmore, et al.
Publicado: (2013)

D-Tagatose Is a Promising Sweetener to Control Glycaemia: A New Functional Food
por: Guerrero-Wyss, Marion, et al.
Publicado: (2018)

Etelcalcetide and Paricalcitol in Chronic Kidney Disease: When the Target Is Inflammation
por: D’Marco, Luis, et al.
Publicado: (2022)

Relationship between Alcohol Consumption and Components of the Metabolic Syndrome in Adult Population from Maracaibo City, Venezuela
por: Bermúdez, Valmore, et al.
Publicado: (2015)

Epidemiologic Behavior and Estimation of an Optimal Cut-Off Point for Homeostasis Model Assessment-2 Insulin Resistance: A Report from a Venezuelan Population
por: Bermúdez, Valmore, et al.
Publicado: (2014)

Cigarette smoking and metabolic syndrome components: a cross-sectional study from Maracaibo City, Venezuela
por: Bermudez, Valmore, et al.
Publicado: (2019)

Prevalence and Associated Factors of Insulin Resistance in Adults from Maracaibo City, Venezuela
por: Bermudez, Valmore, et al.
Publicado: (2016)

Dysfunctional High-Density Lipoprotein: An Innovative Target for Proteomics and Lipidomics
por: Salazar, Juan, et al.
Publicado: (2015)

Durvillaea antarctica: A Seaweed for Enhancing Immune and Cardiometabolic Health and Gut Microbiota Composition Modulation
por: Guerrero-Wyss, Marion, et al.
Publicado: (2023)

Exploring the Relationship between the Gut Microbiota and Ageing: A Possible Age Modulator
por: Salazar, Juan, et al.
Publicado: (2023)

Perirenal fat thickness is associated with metabolic risk factors in patients with chronic kidney disease
por: D’Marco, Luis, et al.
Publicado: (2019)

Pancreatic Beta Cell Death: Novel Potential Mechanisms in Diabetes Therapy
por: Rojas, Joselyn, et al.
Publicado: (2018)

Metabolic Reprogramming in Cancer Cells: Emerging Molecular Mechanisms and Novel Therapeutic Approaches
por: Navarro, Carla, et al.
Publicado: (2022)

Intrinsic and environmental basis of aging: A narrative review
por: Navarro, Carla, et al.
Publicado: (2023)

C-Reactive Protein: An In-Depth Look into Structure, Function, and Regulation
por: Salazar, Juan, et al.
Publicado: (2014)

SGLT2i and GLP-1RA in Cardiometabolic and Renal Diseases: From Glycemic Control to Adipose Tissue Inflammation and Senescence
por: D'Marco, Luis, et al.
Publicado: (2021)

Insulin Withdrawal in Diabetic Kidney Disease: What Are We Waiting for?
por: Morillas, Carlos, et al.
Publicado: (2021)

Polycystic Ovary Syndrome, Insulin Resistance, and Obesity: Navigating the Pathophysiologic Labyrinth
por: Rojas, Joselyn, et al.
Publicado: (2014)

New Evidence on BPA’s Role in Adipose Tissue Development of Proinflammatory Processes and Its Relationship with Obesity
por: González-Casanova, Jorge Enrique, et al.
Publicado: (2023)

Epicardial Adipose Tissue, Adiponectin and Leptin: A Potential Source of Cardiovascular Risk in Chronic Kidney Disease
por: D’Marco, Luis, et al.
Publicado: (2020)

Physiologic Course of Female Reproductive Function: A Molecular Look into the Prologue of Life
por: Rojas, Joselyn, et al.
Publicado: (2015)

Non-albuminuric Diabetic Kidney Disease Phenotype: Beyond Albuminuria
por: D’Marco, Luis, et al.
Publicado: (2022)

Effect of Oral Nutritional Supplements with Sucromalt and Isomaltulose versus Standard Formula on Glycaemic Index, Entero-Insular Axis Peptides and Subjective Appetite in Patients with Type 2 Diabetes: A Randomised Cross-Over Study
por: Dávila, Lisse Angarita, et al.
Publicado: (2019)

Glucosamine for Osteoarthritis: Biological Effects, Clinical Efficacy, and Safety on Glucose Metabolism
por: Salazar, Juan, et al.
Publicado: (2014)

Insulin resistance indices and coronary risk in adults from Maracaibo city, Venezuela: A cross sectional study
por: Salazar, Juan, et al.
Publicado: (2018)

Dyslipidemia: Genetics, lipoprotein lipase and HindIII polymorphism
por: Palacio Rojas, Marcos, et al.
Publicado: (2018)

Signaling mechanisms in mirror image pain pathogenesis
por: Jancalek, Radim
Publicado: (2011)

Probiotics and Gut Microbiota in Obesity: Myths and Realities of a New Health Revolution
por: León Aguilera, Xavier Eugenio, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_v80d2uoap4nkqqsg59n7ga6kj9