Cargando…

Differential Contribution of Protein Factors and 70S Ribosome to Elongation

The growth of the polypeptide chain occurs due to the fast and coordinated work of the ribosome and protein elongation factors, EF-Tu and EF-G. However, the exact contribution of each of these components in the overall balance of translation kinetics remains not fully understood. We created an in vi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Paleskava, Alena, Maksimova, Elena M., Vinogradova, Daria S., Kasatsky, Pavel S., Kirillov, Stanislav V., Konevega, Andrey L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431766/ https://www.ncbi.nlm.nih.gov/pubmed/34502523 http://dx.doi.org/10.3390/ijms22179614

Ejemplares similares

How the initiating ribosome copes with ppGpp to translate mRNAs
por: Vinogradova, Daria S., et al.
Publicado: (2020)

Multifaceted Mechanism of Amicoumacin A Inhibition of Bacterial Translation
por: Maksimova, Elena M., et al.
Publicado: (2021)

Insights into the improved macrolide inhibitory activity from the high-resolution cryo-EM structure of dirithromycin bound to the E. coli 70S ribosome
por: Pichkur, Evgeny B., et al.
Publicado: (2020)

Ribosomal protein S18 acetyltransferase RimI is responsible for the acetylation of elongation factor Tu
por: Pletnev, Philipp I., et al.
Publicado: (2022)

Thiostrepton inhibits stable 70S ribosome binding and ribosome-dependent GTPase activation of elongation factor G and elongation factor 4
por: Walter, Justin D., et al.
Publicado: (2012)

The ribosomal A-site finger is crucial for binding and activation of the stringent factor RelA
por: Kudrin, Pavel, et al.
Publicado: (2018)

Insights into the molecular mechanism of translation inhibition by the ribosome-targeting antibiotic thermorubin
por: Paranjpe, Madhura N, et al.
Publicado: (2022)

Binding and Action of Triphenylphosphonium Analog of Chloramphenicol upon the Bacterial Ribosome
por: Chen, Chih-Wei, et al.
Publicado: (2021)

Brownian dynamics study of the association between the 70S ribosome and elongation factor G
por: Długosz, Maciej, et al.
Publicado: (2011)

The role of GTP in transient splitting of 70S ribosomes by RRF (ribosome recycling factor) and EF-G (elongation factor G)
por: Hirokawa, Go, et al.
Publicado: (2008)

Visualization of Trna Movements on the Escherichia coli 70s Ribosome during the Elongation Cycle
por: Agrawal, Rajendra K., et al.
Publicado: (2000)

Klebsazolicin inhibits 70S ribosome by obstruction of the peptide exit tunnel
por: Metelev, Mikhail, et al.
Publicado: (2017)

Translation Elongation Factor 4 (LepA) Contributes to Tetracycline Susceptibility by Stalling Elongating Ribosomes
por: Liu, Bin, et al.
Publicado: (2018)

Protein Assistants of Small Ribosomal Subunit Biogenesis in Bacteria
por: Maksimova, Elena, et al.
Publicado: (2022)

The dynamic cycle of bacterial translation initiation factor IF3
por: Nakamoto, Jose A, et al.
Publicado: (2021)

Crystal Structure of 70S Ribosome with Both Cognate tRNAs in the E and P Sites Representing an Authentic Elongation Complex
por: Feng, Shu, et al.
Publicado: (2013)

Molecular insights into the interaction of the ribosomal stalk protein with elongation factor 1α
por: Ito, Kosuke, et al.
Publicado: (2014)

Molecular dynamics of ribosomal elongation factors G and Tu
por: Kulczycka, Katarzyna, et al.
Publicado: (2010)

Elongation Factor P Interactions with the Ribosome Are Independent of Pausing
por: Tollerson, Rodney, et al.
Publicado: (2017)

Madumycin II inhibits peptide bond formation by forcing the peptidyl transferase center into an inactive state
por: Osterman, Ilya A., et al.
Publicado: (2017)

Guanine-nucleotide exchange on ribosome-bound elongation factor G initiates the translocation of tRNAs
por: Zavialov, Andrey V, et al.
Publicado: (2005)

Dual use of GTP hydrolysis by elongation factor G on the ribosome
por: Cunha, Carlos E., et al.
Publicado: (2013)

Identification of factors that prevent ribosome stalling during early elongation
por: Hye-Rim, Hong, et al.
Publicado: (2023)

Stm1p alters the ribosome association of eukaryotic elongation factor 3 and affects translation elongation
por: Van Dyke, Natalya, et al.
Publicado: (2009)

In vitro reconstitution of the Escherichia coli 70S ribosome with a full set of recombinant ribosomal proteins
por: Aoyama, Ryo, et al.
Publicado: (2021)

Methylation of yeast ribosomal protein Rpl3 promotes translational elongation fidelity
por: Al-Hadid, Qais, et al.
Publicado: (2016)

Protein synthesis rates and ribosome occupancies reveal determinants of translation elongation rates
por: Riba, Andrea, et al.
Publicado: (2019)

Collisions and protein aggregations ahead: how aging affects ribosomal elongation dynamics
por: Maity, Pallab, et al.
Publicado: (2022)

RNA helicase DDX19 stabilizes ribosomal elongation and termination complexes
por: Mikhailova, Tatiana, et al.
Publicado: (2017)

Pathway of Hsp70 interactions at the ribosome
por: Lee, Kanghyun, et al.
Publicado: (2021)

The structure of an elongation factor G-ribosome complex captured in the absence of inhibitors
por: Macé, Kevin, et al.
Publicado: (2018)

The ABC-F protein EttA gates ribosome entry into the translation elongation cycle
por: Boël, Grégory, et al.
Publicado: (2014)

Peptidyl transferase center decompaction and structural constraints during early protein elongation on the ribosome
por: Jia, Bin, et al.
Publicado: (2021)

Multivalent contacts of the Hsp70 Ssb contribute to its architecture on ribosomes and nascent chain interaction
por: Hanebuth, Marie A., et al.
Publicado: (2016)

Differential Cellular Stiffness Contributes to Tissue Elongation on an Expanding Surface
por: Koyama, Hiroshi, et al.
Publicado: (2022)

Mechanisms of ribosome stalling by SecM at multiple elongation steps
por: Zhang, Jun, et al.
Publicado: (2015)

Tracking fluctuation hotspots on the yeast ribosome through the elongation cycle
por: Gulay, Suna P., et al.
Publicado: (2017)

Inferring efficiency of translation initiation and elongation from ribosome profiling
por: Szavits-Nossan, Juraj, et al.
Publicado: (2020)

Estimation of peptide elongation times from ribosome profiling spectra
por: Pavlov, Michael Y, et al.
Publicado: (2021)

Monosomes buffer translational stress to allow for active ribosome elongation
por: Schieweck, Rico, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_o73okbekepvi2isbl0jouc2nvh