ZEB1 promotes pathogenic Th1 and Th17 cell differentiation in multiple sclerosis

Inappropriate CD4(+) T helper (Th) differentiation can compromise host immunity or promote autoimmune disease. To identify disease-relevant regulators of T cell fate, we examined mutations that modify risk for multiple sclerosis (MS), a canonical organ-specific autoimmune disease. This analysis iden...

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Detalles Bibliográficos
Autores principales: Qian, Yuan, Arellano, Gabriel, Ifergan, Igal, Lin, Jean, Snowden, Caroline, Kim, Taehyeung, Thomas, Jane Joy, Law, Calvin, Guan, Tianxia, Balabanov, Roumen D., Kaech, Susan M., Miller, Stephen D., Choi, Jaehyuk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431781/
https://www.ncbi.nlm.nih.gov/pubmed/34433042
http://dx.doi.org/10.1016/j.celrep.2021.109602

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