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Increase in Akkermansiaceae in Gut Microbiota of Prostate Cancer-Bearing Mice

Gut microbiota are reported to be associated with many diseases, including cancers. Several bacterial taxa have been shown to be associated with cancer development or response to treatment. However, longitudinal microbiota alterations during the development of cancers are relatively unexplored. To b...

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Autores principales: Huang, Pin-Yu, Yang, Yu-Chih, Wang, Chun-I, Hsiao, Pei-Wen, Chiang, Hsin-I, Chen, Ting-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431795/
https://www.ncbi.nlm.nih.gov/pubmed/34502535
http://dx.doi.org/10.3390/ijms22179626
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author Huang, Pin-Yu
Yang, Yu-Chih
Wang, Chun-I
Hsiao, Pei-Wen
Chiang, Hsin-I
Chen, Ting-Wen
author_facet Huang, Pin-Yu
Yang, Yu-Chih
Wang, Chun-I
Hsiao, Pei-Wen
Chiang, Hsin-I
Chen, Ting-Wen
author_sort Huang, Pin-Yu
collection PubMed
description Gut microbiota are reported to be associated with many diseases, including cancers. Several bacterial taxa have been shown to be associated with cancer development or response to treatment. However, longitudinal microbiota alterations during the development of cancers are relatively unexplored. To better understand how microbiota changes, we profiled the gut microbiota composition from prostate cancer-bearing mice and control mice at five different time points. Distinct gut microbiota differences were found between cancer-bearing mice and control mice. Akkermansiaceae was found to be significantly higher in the first three weeks in cancer-bearing mice, which implies its role in the early stage of cancer colonization. We also found that Bifidobacteriaceae and Enterococcaceae were more abundant in the second and last sampling week, respectively. The increments of Akkermansiaceae, Bifidobacteriaceae and Enterococcaceae were previously found to be associated with responses to immunotherapy, which suggests links between these bacteria families and cancers. Additionally, our function analysis showed that the bacterial taxa carrying steroid biosynthesis and butirosin and neomycin biosynthesis were increased, whereas those carrying naphthalene degradation decreased in cancer-bearing mice. Our work identified the bacteria taxa altered during prostate cancer progression and provided a resource of longitudinal microbiota profiles during cancer development in a mouse model.
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spelling pubmed-84317952021-09-11 Increase in Akkermansiaceae in Gut Microbiota of Prostate Cancer-Bearing Mice Huang, Pin-Yu Yang, Yu-Chih Wang, Chun-I Hsiao, Pei-Wen Chiang, Hsin-I Chen, Ting-Wen Int J Mol Sci Article Gut microbiota are reported to be associated with many diseases, including cancers. Several bacterial taxa have been shown to be associated with cancer development or response to treatment. However, longitudinal microbiota alterations during the development of cancers are relatively unexplored. To better understand how microbiota changes, we profiled the gut microbiota composition from prostate cancer-bearing mice and control mice at five different time points. Distinct gut microbiota differences were found between cancer-bearing mice and control mice. Akkermansiaceae was found to be significantly higher in the first three weeks in cancer-bearing mice, which implies its role in the early stage of cancer colonization. We also found that Bifidobacteriaceae and Enterococcaceae were more abundant in the second and last sampling week, respectively. The increments of Akkermansiaceae, Bifidobacteriaceae and Enterococcaceae were previously found to be associated with responses to immunotherapy, which suggests links between these bacteria families and cancers. Additionally, our function analysis showed that the bacterial taxa carrying steroid biosynthesis and butirosin and neomycin biosynthesis were increased, whereas those carrying naphthalene degradation decreased in cancer-bearing mice. Our work identified the bacteria taxa altered during prostate cancer progression and provided a resource of longitudinal microbiota profiles during cancer development in a mouse model. MDPI 2021-09-06 /pmc/articles/PMC8431795/ /pubmed/34502535 http://dx.doi.org/10.3390/ijms22179626 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Huang, Pin-Yu
Yang, Yu-Chih
Wang, Chun-I
Hsiao, Pei-Wen
Chiang, Hsin-I
Chen, Ting-Wen
Increase in Akkermansiaceae in Gut Microbiota of Prostate Cancer-Bearing Mice
title Increase in Akkermansiaceae in Gut Microbiota of Prostate Cancer-Bearing Mice
title_full Increase in Akkermansiaceae in Gut Microbiota of Prostate Cancer-Bearing Mice
title_fullStr Increase in Akkermansiaceae in Gut Microbiota of Prostate Cancer-Bearing Mice
title_full_unstemmed Increase in Akkermansiaceae in Gut Microbiota of Prostate Cancer-Bearing Mice
title_short Increase in Akkermansiaceae in Gut Microbiota of Prostate Cancer-Bearing Mice
title_sort increase in akkermansiaceae in gut microbiota of prostate cancer-bearing mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431795/
https://www.ncbi.nlm.nih.gov/pubmed/34502535
http://dx.doi.org/10.3390/ijms22179626
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