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Role of Brown and Beige Adipose Tissues in Seasonal Adaptation in the Raccoon Dog (Nyctereutes procyonoides)
Brown adipose tissue (BAT) expresses uncoupling protein-1 (UCP1), which enables energy to be exerted towards needed thermogenesis. Beige adipocytes are precursor cells interspersed among white adipose tissue (WAT) that possess similar UCP1 activity and capacity for thermogenesis. The raccoon dog (Ny...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431801/ https://www.ncbi.nlm.nih.gov/pubmed/34502532 http://dx.doi.org/10.3390/ijms22179623 |
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author | Niiranen, Laura Mäkelä, Kari A. Mutt, Shivaprakash J. Viitanen, Riikka Kaisanlahti, Anna Vicente, David Noponen, Tommi Autio, Anu Roivainen, Anne Nuutila, Pirjo Saarela, Seppo Herzig, Karl-Heinz |
author_facet | Niiranen, Laura Mäkelä, Kari A. Mutt, Shivaprakash J. Viitanen, Riikka Kaisanlahti, Anna Vicente, David Noponen, Tommi Autio, Anu Roivainen, Anne Nuutila, Pirjo Saarela, Seppo Herzig, Karl-Heinz |
author_sort | Niiranen, Laura |
collection | PubMed |
description | Brown adipose tissue (BAT) expresses uncoupling protein-1 (UCP1), which enables energy to be exerted towards needed thermogenesis. Beige adipocytes are precursor cells interspersed among white adipose tissue (WAT) that possess similar UCP1 activity and capacity for thermogenesis. The raccoon dog (Nyctereutes procyonoides) is a canid species that utilizes seasonal obesity to survive periods of food shortage in climate zones with cold winters. The potential to recruit a part of the abundant WAT storages as beige adipocytes for UCP1-dependent thermogenesis was investigated in vitro by treating raccoon dog adipocytes with different browning inducing factors. In vivo positron emission tomography/computed tomography (PET/CT) imaging with the glucose analog (18)F-FDG showed that BAT was not detected in the adult raccoon dog during the winter season. In addition, UCP1 expression was not changed in response to chronic treatments with browning inducing factors in adipocyte cultures. Our results demonstrated that most likely the raccoon dog endures cold weather without the induction of BAT or recruitment of beige adipocytes for heat production. Its thick fur coat, insulating fat, and muscle shivering seem to provide the adequate heat needed for surviving the winter. |
format | Online Article Text |
id | pubmed-8431801 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84318012021-09-11 Role of Brown and Beige Adipose Tissues in Seasonal Adaptation in the Raccoon Dog (Nyctereutes procyonoides) Niiranen, Laura Mäkelä, Kari A. Mutt, Shivaprakash J. Viitanen, Riikka Kaisanlahti, Anna Vicente, David Noponen, Tommi Autio, Anu Roivainen, Anne Nuutila, Pirjo Saarela, Seppo Herzig, Karl-Heinz Int J Mol Sci Article Brown adipose tissue (BAT) expresses uncoupling protein-1 (UCP1), which enables energy to be exerted towards needed thermogenesis. Beige adipocytes are precursor cells interspersed among white adipose tissue (WAT) that possess similar UCP1 activity and capacity for thermogenesis. The raccoon dog (Nyctereutes procyonoides) is a canid species that utilizes seasonal obesity to survive periods of food shortage in climate zones with cold winters. The potential to recruit a part of the abundant WAT storages as beige adipocytes for UCP1-dependent thermogenesis was investigated in vitro by treating raccoon dog adipocytes with different browning inducing factors. In vivo positron emission tomography/computed tomography (PET/CT) imaging with the glucose analog (18)F-FDG showed that BAT was not detected in the adult raccoon dog during the winter season. In addition, UCP1 expression was not changed in response to chronic treatments with browning inducing factors in adipocyte cultures. Our results demonstrated that most likely the raccoon dog endures cold weather without the induction of BAT or recruitment of beige adipocytes for heat production. Its thick fur coat, insulating fat, and muscle shivering seem to provide the adequate heat needed for surviving the winter. MDPI 2021-09-06 /pmc/articles/PMC8431801/ /pubmed/34502532 http://dx.doi.org/10.3390/ijms22179623 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Niiranen, Laura Mäkelä, Kari A. Mutt, Shivaprakash J. Viitanen, Riikka Kaisanlahti, Anna Vicente, David Noponen, Tommi Autio, Anu Roivainen, Anne Nuutila, Pirjo Saarela, Seppo Herzig, Karl-Heinz Role of Brown and Beige Adipose Tissues in Seasonal Adaptation in the Raccoon Dog (Nyctereutes procyonoides) |
title | Role of Brown and Beige Adipose Tissues in Seasonal Adaptation in the Raccoon Dog (Nyctereutes procyonoides) |
title_full | Role of Brown and Beige Adipose Tissues in Seasonal Adaptation in the Raccoon Dog (Nyctereutes procyonoides) |
title_fullStr | Role of Brown and Beige Adipose Tissues in Seasonal Adaptation in the Raccoon Dog (Nyctereutes procyonoides) |
title_full_unstemmed | Role of Brown and Beige Adipose Tissues in Seasonal Adaptation in the Raccoon Dog (Nyctereutes procyonoides) |
title_short | Role of Brown and Beige Adipose Tissues in Seasonal Adaptation in the Raccoon Dog (Nyctereutes procyonoides) |
title_sort | role of brown and beige adipose tissues in seasonal adaptation in the raccoon dog (nyctereutes procyonoides) |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431801/ https://www.ncbi.nlm.nih.gov/pubmed/34502532 http://dx.doi.org/10.3390/ijms22179623 |
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