Breathing more breadth into COVID-19 T cell responses

Innate and adaptive heterologous immunity confers resistance to pathogens. However, its impact on resistance and the course of human infection have remained largely elusive, hampering the use of this phenomenon to enhance vaccine efficacy. In this issue of Med, Mysore et al. show that T cell respons...

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Detalles Bibliográficos
Autores principales: Bejarano, David A., Schlitzer, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Inc. 2021
Materias:
Viewpoint
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431966/
https://www.ncbi.nlm.nih.gov/pubmed/34522907
http://dx.doi.org/10.1016/j.medj.2021.08.009
Descripción
Sumario:Innate and adaptive heterologous immunity confers resistance to pathogens. However, its impact on resistance and the course of human infection have remained largely elusive, hampering the use of this phenomenon to enhance vaccine efficacy. In this issue of Med, Mysore et al. show that T cell responses elicited by SARS-CoV-2 infection or vaccination correlate with those induced by MMR and Tdap immunization, revealing the transcriptomic basis of these correlations and find that heterologous adaptive immunity contributes to a better prognosis of COVID-19 disease.(1)

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