Novel vancomycin resistance gene cluster in Enterococcus faecium ST1486, Belgium, June 2021

We identified a novel van gene cluster in a clinical Enterococcus faecium isolate with vancomycin minimum inhibitory concentration (MIC) of 4 µg/mL. The ligase gene, vanP, was part of a van operon cluster of 4,589 bp on a putative novel integrative conjugative element located in a ca 98 kb genomic r...

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Detalles Bibliográficos
Autores principales: Xavier, Basil Britto, Coppens, Jasmine, De Koster, Sien, Rajakani, Sahaya Glingston, Van Goethem, Sam, Mzougui, Samy, Anantharajah, Ahalieyah, Lammens, Christine, Loens, Katherine, Glupczynski, Youri, Goossens, Herman, Matheeussen, Veerle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2021
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431993/
https://www.ncbi.nlm.nih.gov/pubmed/34505571
http://dx.doi.org/10.2807/1560-7917.ES.2021.26.36.2100767
Descripción
Sumario:We identified a novel van gene cluster in a clinical Enterococcus faecium isolate with vancomycin minimum inhibitory concentration (MIC) of 4 µg/mL. The ligase gene, vanP, was part of a van operon cluster of 4,589 bp on a putative novel integrative conjugative element located in a ca 98 kb genomic region presumed to be acquired by horizontal gene transfer from Clostridium scidens and Roseburia sp. 499. Screening for van genes in E. faecium strains with borderline susceptibility to vancomycin is important.

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